U-46619

Product Name: U-46619
CAS No.: 56985-40-1
Chemical Name: U-46619
Synonyms: U-46619;U 46619,U46619;9,11-Methanoxy-PGH2;11-Methanoepoxy PGH2;9,11-Methanoepoxy PGH2;U46619, U-46619, U 46619;11α,9α-Epoxymethanoprostaglandin H2;U-46619 - CAS 56985-40-1 - Calbiochem;9,11-DIDEOXY-11ALPHA,9ALPHA-EPOXYMETHANO;4-alpha,5-beta(z),6-alpha(1e,3s*)))-r-(1-alph
CBNumber: CB6437516
Molecular Formula: C21H34O4
Formula Weight: 350.49
MOL File: 56985-40-1.mol

More

Less

U-46619 Property

Boiling point:: 519.7±30.0 °C(Predicted)
Density: 1.092±0.06 g/cm3(Predicted)
Flash point:: -10 °C
storage temp.: -20°C
solubility: ≥100 mg/mL in DMSO, ≥100 mg/mL in Ethanol, ≥100 mg/mL in DMF, ≥2 mg/mL in PBS pH 7.2
pka: 4.76±0.10(Predicted)
form: solution
BRN: 4267334

More

Less

Safety

Hazard Codes: F,Xi
Risk Statements: 11-36-66-67
Safety Statements: 16-26
RIDADR: UN 1231 3/PG 2
WGK Germany: 2
RTECS: MJ9681090
F: 8-10-23
Toxicity: LD50 intravenous in mouse: 66ug/kg

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D8174
Product name: 9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α
Purity: solution, 10 mg/mL in methyl acetate
Packaging: 1mg
Price: $339
Updated: 2024/03/01

Sigma-Aldrich

Product number: 538944
Product name: U-46619
Packaging: 1mg
Price: $242
Updated: 2022/05/15

Cayman Chemical

Product number: 16450
Product name: U-46619
Purity: ≥98%
Packaging: 1mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 16450
Product name: U-46619
Purity: ≥98%
Packaging: 5mg
Price: $437
Updated: 2024/03/01

Sigma-Aldrich

Product number: D8174
Product name: 9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α
Purity: solution, 10 mg/mL in methyl acetate
Packaging: 5mg
Price: $1330
Updated: 2024/03/01

More

Less

U-46619 Chemical Properties,Usage,Production

Uses

U 46619 is a PGH2 analog that may be used as a thromboxane A2 (TP) receptor agonist affecting mitogenic growth of vascular smooth muscle in humans.

Biological Activity

PGH 2 (TXA 2 ) analog that is a potent and stable thromboxane A 2 (TP) receptor agonist (EC 50 = 0.035 μ M). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK-293 cells expressing TP α and TP β receptors.

Biochem/physiol Actions

Thromboxane receptor agonist.

in vitro

u46619 showed a biphasic effect on human platelets. shape change and mlcp occurred at low concentrations of this compound (ec50 = 0.035 um and 0.057 um), whereas serotonin release, platelet at higher concentrations (ec50 = 0.536 um and 1.31 um). the effect on platelet shape change and mlcp is receptor mediated [3].

in vivo

u46619, through activation of eta and etb receptors, elicits renal cortical vasoconstriction and medullary vasodilation in the rat [2]. in conscious shr (spontaneously hypertensive rats), 1-100 nmol/kg u-46619 (i.c.v.) induced a dose-related increase in blood pressure but had no significant effect on heart rate [1].

storage

Store at -20°C

References

[1] sirén al, svartstrm-fraser m, paakkari i. central cardiovascular effects of the endoperoxide analogue u-46619 in rats. prostaglandins leukot med. 1985 mar; 17 (3): 381-6.
[2] hantz h, adesuyi a, adebayo o. differential effects of u46619 on renal regional hemodynamics in the rat: involvement of endothelin. j pharmacol exp ther. 2001 oct; 299 (1): 372-6.
[3] morinelli ta1, niewiarowski s, daniel jl, smith jb. receptor-mediated effects of a pgh2 analogue (u 46619) on human platelets. am j physiol. 1987 nov; 253 (5 pt 2): h1035-43.

U-46619 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

U-46619 Suppliers

China 39 Germany 1 India 1 Japan 3 Switzerland 2 United Kingdom 2 United States 13 USA 1 Global 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15848
Advantage: 69

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 18521735133 18521732826;
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25014
Advantage: 65

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3423
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6870
Advantage: 58

Hangzhou Synstar pharmaceutical Technology CO.,Ltd

Tel: 0571-85361029
Fax: 0571-85361029
Email: synstar518@163.com
Country: China
ProdList: 1991
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9414
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49391
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

Lingyuan Bebiansen Biological Technology Co., Ltd

Tel: 18642120371
Email: 2837458851@qq.com
Country: China
ProdList: 9874
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 18768175414
Email: gaojun@univ-bio.com
Country: China
ProdList: 24998
Advantage: 58

amyjetsci

Tel: 027-59626688 18771149750
Email: sales@amyjet.com
Country: China
ProdList: 3004
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24018
Advantage: 58

G-CLONE

Tel: 400-910-1997 17560619001
Email: 3243204476@qq.com
Country: China
ProdList: 9959
Advantage: 58

Shanghai Acmec Biochemical Technology Co., Ltd.

Tel: +undefined18621343501
Email: product@acmec-e.com
Country: China
ProdList: 33350
Advantage: 58

Hangzhou MolCore BioPharmatech Co.,Ltd.

Tel: +86-057181025280; +8617767106207
Fax: 0571-85806285
Email: sales@molcore.com
Country: China
ProdList: 49739
Advantage: 58

Shanghai Hao Zhun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: info@zzsrm.com
Country: CHINA
ProdList: 6846
Advantage: 58

Beijing Dongge Boye Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1861586486@qq.com
Country: CHINA
ProdList: 6652
Advantage: 58

Shanghai Yaoyun Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 912529879@qq.com
Country: CHINA
ProdList: 6852
Advantage: 58

Shanghai Hao Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: shxiyuanbio@163.com
Country: CHINA
ProdList: 6921
Advantage: 58

Shanghai Jijin Chemical Technology Co., Ltd.

Tel: --
Fax: --
Email: jijinhuaxue@sina.com
Country: CHINA
ProdList: 6617
Advantage: 58

Beijing Lebo Biotechnology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6057
Advantage: 58

Shanghai Minmin Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: 1914109725@qq.com
Country: CHINA
ProdList: 6530
Advantage: 58

Morning Student Science and Technology (Guangzhou) Co., Ltd.

Tel: --
Fax: --
Email: chenxue_gz@163.com
Country: CHINA
ProdList: 6618
Advantage: 58

Beijing Fubo Biotechnology Co., Ltd.

Tel: --
Fax: --
Email: info@f-biology.com
Country: CHINA
ProdList: 6039
Advantage: 58

Beijing Zhijie Fangyuan Technology Co., Ltd.

Tel: --
Fax: --
Email: 15810200961@163.com
Country: CHINA
ProdList: 6984
Advantage: 58

Shanghai Ziqi Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: 2453006496@qq.com
Country: CHINA
ProdList: 6192
Advantage: 58

Boao Pike

Tel: --
Fax: --
Email: lyn@biopike.com.cn
Country: CHINA
ProdList: 6629
Advantage: 58

Xiamen Huijia Biological Technology Co., Ltd.

Tel: --
Fax: --
Country: CHINA
ProdList: 6979
Advantage: 58

Resenbio

Tel: --
Fax: --
Email: sales@xarxbio.com
Country: China
ProdList: 1777
Advantage: 50

Beijing Taize Ruida Technology Co., Ltd.

Tel: --
Fax: --
Email: taizeorder@163.com
Country: CHINA
ProdList: 6536
Advantage: 58

Shenzhen Xinbosheng Biological Technology Co., Ltd.

Tel: --
Fax: --
Email: service@neobioscience.com
Country: CHINA
ProdList: 6164
Advantage: 58

Guangzhou WeiBo Chemical Co., Ltd.

Tel: --
Fax: --
Email: weibochem@163.com
Country: China
ProdList: 6187
Advantage: 67

56985-40-1, U-46619Related Search:

9,11-DIDEOXY-9ALPHA,11ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA Bromadoline U 75875 METHYLENECYCLOHEXANE ETHYLENE OXIDE DELTA17-U-46619 5-TRANS U-46619 U-46619 [15-3H]- U-46619

9,11-DIDEOXY-11Α,9Α-EPOXYMETHANOPROSTAGLANDIN F2Α,SOLUTION

U-46619 - CAS 56985-40-1 - Calbiochem

9,11-DIDEOXY-11ALPHA,9ALPHA-EPOXYMETHANO

9,11-DIDEOXY-11A,9A-EPOXYMETHANO-*PROSTA GLANDIN F2A

9,11-dideoxy-11α,9α-epoxymethanoprostaglandin f2α

9,11-dideoxy-11alpha,9alpha-epoxymethanoprostaglandin F2a

(5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2 -oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid

(5Z)-7-[(1R,4S)-6β-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]heptan-5α-yl]-5-heptenoic acid

(Z)-7-[(1R,4S)-6β-[(E,S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5α-yl]-5-heptenoic acid

11α,9α-Epoxymethanoprostaglandin H2

9,11-Methanoepoxy PGH2

9,11-Methanoxy-PGH2

9,11-Dideoxy-9α,11α-methanoepoxyprostaglandin F2α Solution

4-alpha,5-beta(z),6-alpha(1e,3s*)))-r-(1-alph

7-(6-(3-hydroxy-1-octenyl)-2-oxabicyclo(2.2.1)hept-5-yl)-5-heptenoicaci(1

9a,11a-methanoepoxy-15-hydroxyprosta-5,13-dienoicacid

U-46619

9,11-dideoxy-11A,9A-epoxymethano-*prostaglandin F

9,11-dideoxy-11alpha,9alpha-epoxymethano prostaglandin F2A S

9,11-DIDEOXY-9ALPHA, 11ALPHA-METHANOEPOXY-PROSTA-5Z,13E-DIEN-1-OIC ACID

9,11-DIDEOXY-9ALPHA, 11ALPHA-METHANOEPOXY-PROSTA-5Z,13E-DIEN-OIC ACID

9,11-DIDEOXY-9ALPHA,11ALPHA-METHANOEPOXYPROSTAGLANDIN F2ALPHA

9,11-DIDEOXY-11ALPHA,9ALPHA-EPOXY-METHANOPROSTAGLANDIN F2ALPHA

9,11-DIDEOXY-9ALPHA,11ALPHA-METHANOEPOXY PGF2ALPHA

5-Heptenoic acid, 7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxy-1-octen-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl]-, (5Z)-

11-Methanoepoxy PGH2

U46619, U-46619, U 46619

U 46619,U46619

56985-40-1

Biochemicals and Reagents

BioChemical

Prostaglandins

Lipids

Fatty Acids

Prostanoid receptor and related