L-CYSTATHIONINE

Product Name: L-CYSTATHIONINE
CAS No.: 56-88-2
Chemical Name: L-CYSTATHIONINE
Synonyms: L-CYSTATHIONINE;L(+)CYSTATHIONINE;CYSTATHIONINE, L-;L-Cystathionine (P);L-Cystathionine Standard;L-CYSTATHIONINE, >= 98% (TLC);CYSTATHIONINE, L-(DS)(REQUEST QUOTE);(2R,7S)-2,7-Diamino-4-thiaoctanedioic acid;[R]-S-[2-AMINO-2-CARBOXYETHYL]-L-HOMOCYSTEINE;S-[(R)-2-Amino-2-carboxyethyl]-L-homocysteine
CBNumber: CB6446239
Molecular Formula: C7H14N2O4S
Formula Weight: 222.26
MOL File: 56-88-2.mol

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L-CYSTATHIONINE Property

Melting point:: 312
alpha: D20 +23.7° (1N HCl)
Density: 1.430±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: -20°C
solubility: Aqueous Acid (Slightly)
form: Solid
Boiling point:: 481.0±45.0 °C(Predicted)
pka: 2.08±0.10(Predicted)
color: White to Off-White
optical activity: +26.425 (1 mol dm-3 HCl)
Merck: 13,2807
BRN: 2505200

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Safety

WGK Germany: 3
F: 10-21
HS Code: 29309090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C7505
Product name: L-Cystathionine
Purity: ≥98% (TLC)
Packaging: 10mg
Price: $108
Updated: 2024/03/01

Sigma-Aldrich

Product number: C7505
Product name: L-Cystathionine
Purity: ≥98% (TLC)
Packaging: 50mg
Price: $380
Updated: 2024/03/01

Cayman Chemical

Product number: 16061
Product name: L-(+)-Cystathionine
Purity: ≥98%
Packaging: 5mg
Price: $46
Updated: 2024/03/01

Cayman Chemical

Product number: 16061
Product name: L-(+)-Cystathionine
Purity: ≥98%
Packaging: 10mg
Price: $74
Updated: 2024/03/01

Sigma-Aldrich

Product number: C7505
Product name: L-Cystathionine
Purity: ≥98% (TLC)
Packaging: 250mg
Price: $1520
Updated: 2024/03/01

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L-CYSTATHIONINE Chemical Properties,Usage,Production

Description

L-(+)-Cystathionine is a dipeptide formed by serine and homocysteine. Transsulfuration of methionine yields homocysteine, which combines with serine to form this precursor of cysteine. L-(+)-Cystathionine is largely expressed in the mammalian brain and deficiency can indicate the presence of metabolic disorders such as cystathioninuria.

Chemical Properties

White Crystalline Solid

Uses

Intermediate in transsulfuration whereby the mammal transfers the sulfur of methionine via homocysteine to cysteine

Uses

L-Cystathionine has been used in ultra-performance liquid chromatography for the validation of cystathionine and the correlation of its abundance with vertebrate metamorphosis. It has also been used as an inhibitor of sinusoidal GSH (glutathione) carrier to signify that thiol redox state imbalance is associated with the modulation of autophagy in carcinoma cells.

Definition

ChEBI: L-cystathionine is a modified amino acid generated by enzymic means from L-homocysteine and L-serine. It has a role as a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a tautomer of a L-cystathionine dizwitterion.

Biochem/physiol Actions

L-Cystathionine is an intermediate in the biosynthesis of L-cysteine and methionine. It is used as a substrate to differentiate and analyze cystathionine γ-lyase(s). L-Cystathionine is an important non-protein amino acid and is associated with metabolic disorders. In recent studies, L-cystathionine is believed to be the precursor of cyclic imino acid cyclothionine. Cystathioninuria is characterized with imino acid cyclothionine excretion in the urine.

Purification Methods

S,S-Cystathionine is purified by converting it to the HCl salt in 20% HCl and carefully basifying with aqueous NH3 until separation is complete. Filter it off and dry it in a vacuum. It forms prisms from H2O. The dibenzoyl derivative has m 229o (from EtOH). [IR: Greenstein & Winitz Chemistry of the Amino Acids (J Wiley) Vol 3 p2690 1961 and Tallan et al. J Biol Chem 230 707 1958, Synthesis: du Vigneaud et al. J Biol Chem 143 59 1942, Anslow et al. J Biol Chem 166 39 1946.] [Prepn: Weiss & Stekol J Am Chem Soc 73 2497 1951; see also du Vigneaud et al. J Biol Chem 143 60 1942, Biological synthesis: Greenberg Methods Enzymol 5 943 1962, Beilstein 4 IV 3197.]

L-CYSTATHIONINE Preparation Products And Raw materials

Raw materials

Preparation Products

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L-CYSTATHIONINE Suppliers

Canada 1 China 100 Germany 1 Japan 1 South Korea 1 Switzerland 1 United Kingdom 5 United States 17 Global 127

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View Lastest Price from L-CYSTATHIONINE manufacturers

Career Henan Chemical Co

Product: L-Cystathionine 56-88-2
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 1000kg
Release date: 2018-12-25

56-88-2, L-CYSTATHIONINERelated Search:

CYSTATHIONINE, D-(P),CYSTATHIONINE, L-(RG) D,L-CYSTATHIONINE,dl,dl-allo-cystathionine,CYSTATHIONINE,DL,DL-allo-Cystathionine, S-(2-Amino-2-carboxyethyl)homocysteine L-CYSTATHIONINE DI-FMOC-L-CYSTATHIONINE BUTANOIC ACID, 2-AMINO-4-[(S)-[(2R)-2-AMINO-2-CARBOXYETHYL]SULFINYL]-, (2S)- DI-BOC-L-CYSTATHIONINE L-Cystathionine -lyase CYSTATHIONINE, D-,D-CYSTATHIONINE Cystathionine beta-Synthase DI-FMOC-DL-CYSTATHIONINE DI-BOC-DL-CYSTATHIONINE DL-Allocystathionine CYSTATHIONINE 10MG [R] Cystathionine ketimine Cystathionine sulfoxide Cystathionine gamma-Lyase Cyclic cystathionine cystathionine beta-lyase

CYSTATHIONINE, L-

L(+)CYSTATHIONINE

L-CYSTATHIONINE

L-CYSTATHIONINE, >= 98% (TLC)

[R]-S-[2-AMINO-2-CARBOXYETHYL]-L-HOMOCYSTEINE

(2S)-2-amino-4-[(2R)-2-amino-3-hydroxy-3-oxopropyl]sulfanylbutanoic acid

L-Cystathionine,(R)-S-(2-Amino-2-carboxyethyl)-L-homocysteine

(2S)-2-Amino-4-{[(2R)-2-amino-2-carboxyethyl]thio}butanoic acid

[R-(R*,S*)]-2-AMino-4-[(2-aMino-2-carboxyethyl)thio]butanoic Acid

S-[(2R)-2-AMino-2-carboxyethyl]-L-hoMocysteine

CYSTATHIONINE, L-(DS)(REQUEST QUOTE)

(2R,7S)-2,7-Diamino-4-thiaoctanedioic acid

S-[(R)-2-Amino-2-carboxyethyl]-L-homocysteine

L-Homocysteine, S-[(2R)-2-amino-2-carboxyethyl]-

L-Cystathionine Standard

L-Cystathionine (P)

56-88-2

Amino Acid Library

BioChemical

Metabolic Libraries

Metabolomics

Cysteine Derivatives

Peptide Synthesis

Specialty Synthesis

Unnatural Amino Acid Derivatives

Amino Acids 13C, 2H, 15N

Amino Acids & Derivatives

Intermediates

Sulfur & Selenium Compounds