METHYL 5-AMINOPYRIMIDINE-2-CARBOXYLATE
- Product Name
- METHYL 5-AMINOPYRIMIDINE-2-CARBOXYLATE
- CAS No.
- 73418-88-9
- Chemical Name
- METHYL 5-AMINOPYRIMIDINE-2-CARBOXYLATE
- Synonyms
- Methyl 5-aMinopyriMidine-...;METHYL 5-AMINOPYRIMIDINE-2-CARBOXYLATE;2-Pyrimidinecarboxylic acid, 5-amino-, methyl ester;2-Pyrimidinecarboxylicacid,5-amino-,methylester(9CI);5-amino-2-Pyrimidinecarboxylic acid methyl ester (9CI ACI);2-Pyrimidinecarboxylic acid, 5-amino-, methyl ester (9CI, ACI)
- CBNumber
- CB6449098
- Molecular Formula
- C6H7N3O2
- Formula Weight
- 153.14
- MOL File
- 73418-88-9.mol
METHYL 5-AMINOPYRIMIDINE-2-CARBOXYLATE Property
- Boiling point:
- 348.3±34.0 °C(Predicted)
- Density
- 1.319±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.10±0.22(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M878090
- Product name
- Methyl5-aminopyrimidine-2-carboxylate
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CHM0379548
- Product name
- METHYL-5-AMINOPYRIMIDINE-2-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $506
- Updated
- 2021/12/16
- Product number
- 3573AL
- Product name
- Methyl5-aminopyrimidine-2-carboxylate
- Packaging
- 250mg
- Price
- $253
- Updated
- 2021/12/16
- Product number
- 4H58-1-VS
- Product name
- Methyl 5-aminopyrimidine-2-carboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $790
- Updated
- 2021/12/16
- Product number
- 115393
- Product name
- Methyl 5-aminopyrimidine-2-carboxylate
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $983
- Updated
- 2021/12/16
METHYL 5-AMINOPYRIMIDINE-2-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
67-56-1
56621-98-8
73418-88-9
The general procedure for the synthesis of methyl 5-aminopyrimidine-2-carboxylate from methanol and 5-aminopyrimidine-2-carboxylic acid was as follows: 5-aminopyrimidine-2-carboxylic acid (Goldenbridge Pharma, Inc.; 5.70 g, 41.0 mmol) was suspended in methanol (120 mL) and cooled in an ice water bath. Subsequently, thionyl chloride (8.97 mL, 123 mmol) was added slowly and dropwise. The resulting suspension was heated and refluxed for 20 h. After completion of the reaction, the mixture was concentrated to give a yellow solid. The solid was dissolved in saturated aqueous sodium bicarbonate (60 mL) and extracted with ethyl acetate using a Gregar extractor. The extract was concentrated to give methyl 5-aminopyrimidine-2-carboxylate (4.26 g, 68% yield) as an off-white solid.1H NMR (400 MHz, CDCl3): δ 8.32 (s, 2H), 4.35 (br s, 2H), 4.02 (s, 3H).
References
[1] Patent: WO2014/138484, 2014, A1. Location in patent: Page/Page column 183
[2] Chemical and Pharmaceutical Bulletin, 2000, vol. 48, # 10, p. 1504 - 1513
METHYL 5-AMINOPYRIMIDINE-2-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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