ChemicalBook > CAS DataBase List > CHEMBRDG-BB 9070752

CHEMBRDG-BB 9070752

Product Name
CHEMBRDG-BB 9070752
CAS No.
719282-11-8
Chemical Name
CHEMBRDG-BB 9070752
Synonyms
AKOS BC-3333;CHEMBRDG-BB 9070752;5-ACETAMIDO-2-CHLOROBENZOIC ACID;5-(Acetylamino)-2-Chlorobenzoic Acid;2-Chloro-5-(acetylamino)benzoic acid;Benzoic acid, 5-(acetylamino)-2-chloro-;5-(acetylamino)-2-chlorobenzoic acid(SALTDATA: FREE)
CBNumber
CB6452188
Molecular Formula
C9H8ClNO3
Formula Weight
213.62
MOL File
719282-11-8.mol
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CHEMBRDG-BB 9070752 Property

storage temp. 
Sealed in dry,Room Temperature
Appearance
Brown to black Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B400628
Product name
5-Acetamido-2-chlorobenzoicAcid
Packaging
500mg
Price
$200
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA52904
Product name
5-(Acetylamino)-2-Chlorobenzoic Acid
Packaging
500mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
5742AH
Product name
5-(Acetylamino)-2-chlorobenzoicacid
Packaging
1g
Price
$104
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA52904
Product name
5-(Acetylamino)-2-Chlorobenzoic Acid
Packaging
1g
Price
$125.4
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA52904
Product name
5-(Acetylamino)-2-Chlorobenzoic Acid
Packaging
2g
Price
$200.6
Updated
2021/12/16
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CHEMBRDG-BB 9070752 Chemical Properties,Usage,Production

Uses

5-Acetamido-2-chlorobenzoic Acid is used for preparation of 2-amino-5-substituted pyrimidine kinase inhibitors and use in therapy.

Synthesis

89-54-3

75-36-5

719282-11-8

1. In a dry reaction flask, 5-amino-2-chlorobenzoic acid (0.50 g, 2.9 mmol) was dissolved in dichloromethane (15 mL). 2. Acetyl chloride (0.30 mL, 4.2 mmol) and triethylamine (1.2 mL, 8.6 mmol) were added sequentially to the above solution. 3. The reaction mixture was stirred at room temperature for 2 h. When the reaction was complete, the mixture was slowly poured into water. 4. The aqueous phase was extracted with ethyl acetate and the organic layers were combined. 5. The combined organic layers were washed sequentially with water and saturated saline. 6. 6. The organic layer was dried over anhydrous sodium sulfate and filtered to remove the desiccant. 7. The filtrate was concentrated under pressure to give 5-(acetylamino)-2-chlorobenzoic acid (0.17 g, 27% yield) as a brown solid.

References

[1] Patent: WO2008/8234, 2008, A1. Location in patent: Page/Page column 115

CHEMBRDG-BB 9070752 Preparation Products And Raw materials

Raw materials

Preparation Products

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CHEMBRDG-BB 9070752 Suppliers

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719282-11-8, CHEMBRDG-BB 9070752Related Search:


  • CHEMBRDG-BB 9070752
  • 5-(Acetylamino)-2-Chlorobenzoic Acid
  • 5-ACETAMIDO-2-CHLOROBENZOIC ACID
  • AKOS BC-3333
  • 5-(acetylamino)-2-chlorobenzoic acid(SALTDATA: FREE)
  • Benzoic acid, 5-(acetylamino)-2-chloro-
  • 2-Chloro-5-(acetylamino)benzoic acid
  • 719282-11-8