SULFISOMIDINE
- Product Name
- SULFISOMIDINE
- CAS No.
- 515-64-0
- Chemical Name
- SULFISOMIDINE
- Synonyms
- Sulfaisodimidine;SULFISOMIDIN;Domian;erycon;Elcosin;Elkosil;Elkosin;Mefenal;Elcosine;Elkosine
- CBNumber
- CB6455785
- Molecular Formula
- C12H14N4O2S
- Formula Weight
- 278.33
- MOL File
- 515-64-0.mol
SULFISOMIDINE Property
- Melting point:
- 245°C
- Boiling point:
- 294°C (rough estimate)
- Density
- 1.2997 (rough estimate)
- refractive index
- 1.6440 (estimate)
- storage temp.
- 0-6°C
- solubility
- Acetonitrile (Slightly), DMSO (Slightly)
- pka
- pKa 7.25 (Uncertain)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- 1.382g/L(25 ºC)
- Merck
- 8951
- BRN
- 261305
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-36-26
- RIDADR
- 3249
- WGK Germany
- 2
- RTECS
- WO9270000
- HazardClass
- 6.1(b)
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 46908
- Product name
- Sulfisomidin
- Purity
- VETRANAL?, analytical standard
- Packaging
- 250mg
- Price
- $53.6
- Updated
- 2022/05/15
- Product number
- S699378
- Product name
- Sulfisomidine
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FA131378
- Product name
- 4-Amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 136051
- Product name
- 4-Amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide
- Purity
- 95%+
- Packaging
- 5g
- Price
- $323
- Updated
- 2021/12/16
- Product number
- API0007837
- Product name
- SULFISOMIDINE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $400.3
- Updated
- 2021/12/16
SULFISOMIDINE Chemical Properties,Usage,Production
Originator
Elkosin,Ciba,US,1951
Uses
Sulfisomidine is a sulfanilamide antibacterial agent.
Definition
ChEBI: A sulfonamide consisting of pyrimidine having methyl substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.
Manufacturing Process
This starting material can be prepared as follows. 123 parts of finely
powdered 6-amino-2,4-dimethylpyrimidine are suspended in 250 parts of dry
pyridine and 222 parts of p-nitrobenzenesulfonyl chloride added at 50°C to
55°C. The whole is then warmed for 2 hours to 55°C. Water is added to the
crystalline aggregate obtained, the precipitated bis-N-(pnitrobenzenesulfonyl)-
6-amino-2,4-dimethylpyrimidine filtered off by suction
and washed with water. It is purified by recrystallizing from methyl ethyl
ketone. On slowly heating it decomposes; on rapidly heating it melts at about
210°C to 215°C with decomposition.
49.3 parts of bis-N-(p-nitrobenzenesulfonyl)-6-amino-2,4-dimethylpyrimidine
are heated to boiling for one hour with 12.3 parts of 6-amino-2,4-
dimethylpyrimidine in 50 parts of dry pyridine. After cooling, the 6-(pnitrobenzenesulfonamido)-
2,4-dimethylpyrimidine formed is precipitated with
water and filtered off by suction. It is purified by dissolving in dilute caustic
soda and precipitating with acid. On recrystallization from dilute alcohol it
melts (with decomposition) at 188°C to 189°C.
On reaction, for example, with iron and hydrochloric acid, 6-(paminobenzenesulfonamido)-
2,4-dimethylpyrimidine, melting point 236°C is
obtained.
brand name
Isosulf;Oestro-gynedron;Poly-gynedron;Sulfamethine;Tricho-gynedron.
Therapeutic Function
Antibacterial
World Health Organization (WHO)
Sulfisomide, a sulfonamide anti-infective agent, was introduced several decades ago for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfisomide is still used topically in some countries for vaginal infection.
Pharmaceutical Applications
6-Sulfanilamido-2,4-dimethylpyrimidine (syn: sulphasomidine). A highly soluble sulfonamide with a plasma half-life of 6–8 h. Protein binding is about 90%. Activity is similar to that of sulfadiazine. It is less extensively metabolized than most other sulfonamides and is largely excreted unchanged in the urine.
SULFISOMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from SULFISOMIDINE manufacturers
- Product
- SULFISOMIDINE 515-64-0
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-15