ChemicalBook > CAS DataBase List > SULFISOMIDINE

SULFISOMIDINE

Product Name
SULFISOMIDINE
CAS No.
515-64-0
Chemical Name
SULFISOMIDINE
Synonyms
Sulfaisodimidine;SULFISOMIDIN;Domian;erycon;Elcosin;Elkosil;Elkosin;Mefenal;Elcosine;Elkosine
CBNumber
CB6455785
Molecular Formula
C12H14N4O2S
Formula Weight
278.33
MOL File
515-64-0.mol
More
Less

SULFISOMIDINE Property

Melting point:
245°C
Boiling point:
294°C (rough estimate)
Density 
1.2997 (rough estimate)
refractive index 
1.6440 (estimate)
storage temp. 
0-6°C
solubility 
Acetonitrile (Slightly), DMSO (Slightly)
pka
pKa 7.25 (Uncertain)
form 
Solid
color 
White to Off-White
Water Solubility 
1.382g/L(25 ºC)
Merck 
8951
BRN 
261305
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
RIDADR 
3249
WGK Germany 
2
RTECS 
WO9270000
HazardClass 
6.1(b)
PackingGroup 
III
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
46908
Product name
Sulfisomidin
Purity
VETRANAL?, analytical standard
Packaging
250mg
Price
$53.6
Updated
2022/05/15
TRC
Product number
S699378
Product name
Sulfisomidine
Packaging
25mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA131378
Product name
4-Amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide
Packaging
500mg
Price
$50
Updated
2021/12/16
Matrix Scientific
Product number
136051
Product name
4-Amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide
Purity
95%+
Packaging
5g
Price
$323
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0007837
Product name
SULFISOMIDINE
Purity
95.00%
Packaging
10MG
Price
$400.3
Updated
2021/12/16
More
Less

SULFISOMIDINE Chemical Properties,Usage,Production

Originator

Elkosin,Ciba,US,1951

Uses

Sulfisomidine is a sulfanilamide antibacterial agent.

Definition

ChEBI: A sulfonamide consisting of pyrimidine having methyl substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position.

Manufacturing Process

This starting material can be prepared as follows. 123 parts of finely powdered 6-amino-2,4-dimethylpyrimidine are suspended in 250 parts of dry pyridine and 222 parts of p-nitrobenzenesulfonyl chloride added at 50°C to 55°C. The whole is then warmed for 2 hours to 55°C. Water is added to the crystalline aggregate obtained, the precipitated bis-N-(pnitrobenzenesulfonyl)- 6-amino-2,4-dimethylpyrimidine filtered off by suction and washed with water. It is purified by recrystallizing from methyl ethyl ketone. On slowly heating it decomposes; on rapidly heating it melts at about 210°C to 215°C with decomposition.
49.3 parts of bis-N-(p-nitrobenzenesulfonyl)-6-amino-2,4-dimethylpyrimidine are heated to boiling for one hour with 12.3 parts of 6-amino-2,4- dimethylpyrimidine in 50 parts of dry pyridine. After cooling, the 6-(pnitrobenzenesulfonamido)- 2,4-dimethylpyrimidine formed is precipitated with water and filtered off by suction. It is purified by dissolving in dilute caustic soda and precipitating with acid. On recrystallization from dilute alcohol it melts (with decomposition) at 188°C to 189°C.
On reaction, for example, with iron and hydrochloric acid, 6-(paminobenzenesulfonamido)- 2,4-dimethylpyrimidine, melting point 236°C is obtained.

brand name

Isosulf;Oestro-gynedron;Poly-gynedron;Sulfamethine;Tricho-gynedron.

Therapeutic Function

Antibacterial

World Health Organization (WHO)

Sulfisomide, a sulfonamide anti-infective agent, was introduced several decades ago for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing resistance and their replacement by antibiotics which are generally more active and less toxic. The sulfonamides are known to cause serious adverse effects such as renal toxicity, sometimes fatal exfoliative dermatitis and erythema multiforma and dangerous adverse reactions affecting blood formation such as agranulocytosis and haemolytic or aplastic anaemia. Sulfisomide is still used topically in some countries for vaginal infection.

Pharmaceutical Applications

6-Sulfanilamido-2,4-dimethylpyrimidine (syn: sulphasomidine). A highly soluble sulfonamide with a plasma half-life of 6–8 h. Protein binding is about 90%. Activity is similar to that of sulfadiazine. It is less extensively metabolized than most other sulfonamides and is largely excreted unchanged in the urine.

SULFISOMIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SULFISOMIDINE Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18738
Advantage
57
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Spectrum Chemical Manufacturing Corp.
Tel
021-021-021-67601398-809-809-809 15221380277
Fax
021-57711696
Email
marketing_china@spectrumchemical.com
Country
China
ProdList
9658
Advantage
60
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
More
Less

View Lastest Price from SULFISOMIDINE manufacturers

Career Henan Chemical Co
Product
SULFISOMIDINE 515-64-0
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-15

515-64-0, SULFISOMIDINERelated Search:


  • (p-aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidin
  • (p-Aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidine
  • 2,4-Dimethyl-6-sulfanilamidopyrimidine
  • 2,6-Dimethyl-4-sulfanilamidopyrimidine
  • 4-amino-n-(2,6-dimethyl-4-pyrimidinyl)-benzenesulfonamid
  • 4-Sulfa-2,6-dimethylpyrimidine
  • 4-Sulfanilamido-2,6-dimethylpyrimidine
  • 6-(4-Aminobenzenesulfonamido)-2,4-dimethylpyrimidine
  • 6-(p-Aminobenzenesulfonamido)-2,4-dimethylpyrimidine
  • 6-(p-Aminobenzenesulfonyl)amino-2,4-dimethylpyrimidine
  • 6-(p-aminophenylsulfonamido)-2,4-dimethylpyrimidine
  • 6-[(p-aminobenzenesulfonyl)amino]-2,4-dimethylpyrimidine
  • 6-Sulfanilamido-2,4-dimethylpyrimidine
  • Aristamid
  • Aristamide
  • Aristogyn
  • Benzenesulfonamide, 4-amino-N-(2,6-dimethyl-4-pyrimidinyl)-
  • benzenesulfonamide,4-amino-N-(2,6-dimethyl-4-pyrimidinyl)-
  • Domian
  • Elcosin
  • N1-(2,6-DIMETHYLPYRIMIDIN-4-YL)SULFANILAMIDE
  • SULFISOMIDIN
  • SULFISOMIDINE
  • Elcosine
  • Elkosil
  • Elkosin
  • Elkosine
  • erycon
  • Mefenal
  • n(sup1)-(2,6-dimethyl-4-pyrimidinyl)-sulfanilamid
  • n(sup1)-(2,6-dimethyl-4-pyrimidinyl)sulfanilamide
  • N<sup>1</sup>-(2,6-Dimethyl-4-pyrimidinyl)sulfanilamide
  • N1-(2,6-dimethyl-4-pyrimidinyl)sulfanilamide
  • Sulfadimetine
  • Sulfaisodimerazine
  • Sulfaisodimidine
  • Sulfamethin
  • Sulfanilamide, N<sup>1</sup>-(2,6-dimethyl-4-pyrimidinyl)-
  • sulfanilamide,N1-(2,6-dimethyl-4-pyrimidinyl)-
  • Sulfasomidine
  • Sulphasomidine
  • AKOS BBS-00004571
  • 4-AMINO-N-(2,6-DIMETHYL-4-PYRIMIDINYL)BENZENESULFONAMIDE
  • N1-(2,6-dimethylpyrimidin-4-yl)sulphanilamide
  • SULPHISOMIDINE
  • SULFISOMIDINE STANDARD
  • 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide, N1-(2,6-Dimethylpyrimidin-4-yl)sulfanilamide
  • 4-amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide
  • 4-azanyl-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide
  • SULFISOMIDIN VETRANAL
  • Sulfisomidine solution,100ppm
  • (p-Aminobenzolsulfonyl)-4-amino-2,6-dimethylpyrimidin [German]
  • 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide (9CI)
  • 6-(p-Aminobenzenesulfo
  • Sulfisomidine (JAN)
  • Sulfisomidine (TN)
  • Sulfisomidine &gt
  • Sulfisomidine Solution in Methanol, 1000μg/mL