PYRAZINE-2-CARBOXAMIDINE HYDROCHLORIDE
- Product Name
- PYRAZINE-2-CARBOXAMIDINE HYDROCHLORIDE
- CAS No.
- 138588-41-7
- Chemical Name
- PYRAZINE-2-CARBOXAMIDINE HYDROCHLORIDE
- Synonyms
- AIDS070607;AIDS-070607;BUTTPARK 32\03-57;pyrazine-2-carboximidamide;pyrazinamidine hydrochloride;PYRAZINE-2-CARBOXAMIDINE HCL;2-pyrazinecarboxamidine hydrochloride;PYRAZINE-2-CARBOXAMIDINE HYDROCHLORIDE;PYRAZINE-2-CARBOXIMIDAMIDE HYDROCHLORIDE;Pyrazine-2-carboximidamide monohydrochloride
- CBNumber
- CB6457613
- Molecular Formula
- C5H7ClN4
- Formula Weight
- 158.59
- MOL File
- 138588-41-7.mol
PYRAZINE-2-CARBOXAMIDINE HYDROCHLORIDE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- White
- CAS DataBase Reference
- 138588-41-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P840883
- Product name
- Pyrazine-2-carboxamidineHydrochloride
- Packaging
- 10g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- OR3402
- Product name
- Pyrazine-2-carboxamidinehydrochloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $63
- Updated
- 2021/12/16
- Product number
- 3H41-5-X4
- Product name
- Pyrazine-2-carboxamidinehydrochloride
- Purity
- 97%
- Packaging
- 5G
- Price
- $69
- Updated
- 2021/12/16
- Product number
- OR3402
- Product name
- Pyrazine-2-carboxamidinehydrochloride
- Purity
- 97%
- Packaging
- 10g
- Price
- $99
- Updated
- 2021/12/16
- Product number
- R154
- Product name
- Pyrazine-2-carboximidamide
- Packaging
- 5g
- Price
- $109
- Updated
- 2021/12/16
PYRAZINE-2-CARBOXAMIDINE HYDROCHLORIDE Chemical Properties,Usage,Production
Synthesis
19847-12-2
138588-41-7
The general procedure for the synthesis of 2-pyrazinamidine hydrochloride from 2-cyanopyrazine was as follows: 2-cyanopyrazine (1.00 kg, 9.53 mol) was slowly added to a solution of sodium methanol (NaOCH3, 51.4 g, 0.952 mol) in methanol (3800 mL) at room temperature. The reaction mixture was heated to 30 °C and stirred for 6 hours. Upon completion of the reaction, the mixture was cooled to 25 °C, followed by the addition of ammonium chloride (NH4Cl, 572 g, 10.5 mol). Stirring of the reaction mixture was continued for 22 hours. At the end of the reaction, methyl tert-butyl ether (4000 mL) was added and stirred for 15 minutes to promote solid formation. The solid product was collected by filtration and washed with methyl tert-butyl ether (2 x 1000 mL). Finally, the product was dried at 40 °C, 0-10 mmHg for 17 h to give the white solid product 2-pyrazinamidine hydrochloride (1435 g) in 95% yield and 95% purity by HPLC.1H NMR (DMSO-D6) data were as follows: δ 9.7 (broad single peak, 3H), 9.49 (double peak, 1H, J=1.5Hz), 9.04 (multiple peaks, 1H), 8.93 (multiple peaks, 1H), 9.04 (multiple peaks, 1H), 8.93 (multiple peaks 1H), 8.93 (triple peak, 1H, J=1.5Hz).
References
[1] Patent: US2006/281760, 2006, A1. Location in patent: Page/Page column 5; 8
[2] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 1, p. 111 - 118
[3] Patent: US2005/75357, 2005, A1. Location in patent: Page/Page column 35
[4] Patent: WO2005/79798, 2005, A1. Location in patent: Page/Page column 150
[5] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 1, p. 299 - 301
PYRAZINE-2-CARBOXAMIDINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from PYRAZINE-2-CARBOXAMIDINE HYDROCHLORIDE manufacturers
- Product
- PYRAZINE-2-CARBOXAMIDINE HYDROCHLORIDE 138588-41-7
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-03-13