ChemicalBook > CAS DataBase List > 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
- Product Name
- 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
- CAS No.
- 153559-76-3
- Chemical Name
- 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID
- Synonyms
- LG 268;CD 3127;lg100268;ALRT 268;LGD 1268;AGN 192620;LGD 100268;hthalenyl)cyclopropyl)-;3-pyridinecarboxylicacid,6-(1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-nap;6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)cyclopropyl]nicotinic Acid
- CBNumber
- CB6458625
- Molecular Formula
- C24H29NO2
- Formula Weight
- 363.49
- MOL File
- 153559-76-3.mol
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6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Property
- Melting point:
- 275-277°C
- Boiling point:
- 487.0±33.0 °C(Predicted)
- Density
- 1.115±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: ≥5mg/mL (warmed)
- pka
- 2.35±0.10(Predicted)
- form
- powder
- color
- white to beige
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0279
- Product name
- LG100268
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $148
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- SML0279
- Product name
- LG100268
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $584
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 21606
- Product name
- LG 100268
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21606
- Product name
- LG 100268
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21606
- Product name
- LG 100268
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $214
- Updated
- 2024/03/01
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6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
LG 100268 is a potent RXR agonist for evaluation in the treatment of non-insulin-dependent (type II) diabetes mellitus (NIDDM).
Biochem/physiol Actions
LG100268 (LG268) is a potent and selective rexinoid and retinoid-X receptor (RXR) agonist. LG100268 binds to the α, β and γ RXR receptors with an IC50 = 3-4 nM and has no activity at the RAR retinoic acid receptors.
in vivo
LG100268 (oral diet; 100 mg/kg; once daily; 7 weeks) combines with C/P presents a more markedly reduced average tumor burden than LG268 or C/P alone. The combination establish a reduced lung tumors, which represents a reduction of 82% (vs. 59%-67% with the single drugs) in comparison with the controls[3].
| Animal Model: | A/J mice[3] |
| Dosage: | 50 mg/kg (Combines with carboplatin (50 mg/kg i.p.) starts 1 week after the LG268 treatment diet) |
| Administration: | Oral diet; once daily; 7 weeks |
| Result: | Decreased lung tumors growth significantly in mice. |
storage
Store at -20°C
6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACID Suppliers
153559-76-3, 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-CYCLOPROPYL]-NICOTINIC ACIDRelated Search:
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