Palmitic anhydride Property

Melting point:

61-64 °C (lit.)

Boiling point:

547.77°C (rough estimate)

Density 

0.8388

refractive index 

1.4364 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

almost transparency in Toluene

form 

powder to crystal

color 

White to Almost white

BRN 

1807507

LogP

14.107 (est)

CAS DataBase Reference

623-65-4(CAS DataBase Reference)

EPA Substance Registry System

Palmitic acid anhydride (623-65-4)

Safety

Hazard Codes 

C

Risk Statements 

34

Safety Statements 

26-36/37/39-45-25

RIDADR 

UN 3261 8/PG 2

WGK Germany 

3

F 

10-21

HazardClass 

8

PackingGroup 

III

HS Code 

29159000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

Precautionary statements

P234Keep only in original container.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P390Absorb spillage to prevent material damage.

P405Store locked up.

P406Store in corrosive resistant/… container with a resistant inner liner.

P501Dispose of contents/container to..…

Palmitic anhydride Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

Palmitic anhydride was used in the synthesis of water-soluble N-palmitoyl chitosan (PLCS) by coupling with swollen chitosan in dimethyl sulfoxide (DMSO). It was also used in the synthesis of N-acylphosphatidylserine.

General Description

Palmitic anhydride reacted with 20-methyl spirolide G to form a derivative with a retention time and spectrum identical with the metabolite, 17-O-palmitoyl-20-methyl spirolide G.

Purification Methods

It is moisture sensitive and hydrolyses in water. Purify it by refluxing with acetic anhydride for 1hour, evaporating and freeing the residue of acetic acid and anhydride by drying the residue at high vacuum and recrystallising from pet ether at low temperature. [Beilstein 2 IV 1181.]