5-BROMO-2-METHYL-2-PENTENE
- Product Name
- 5-BROMO-2-METHYL-2-PENTENE
- CAS No.
- 2270-59-9
- Chemical Name
- 5-BROMO-2-METHYL-2-PENTENE
- Synonyms
- NSC 244464;Homoprenyl bromide;Prenylmethyl bromide;5-BROMO-2-METHYLPENT-2-ENE;5-BROMO-2-METHYL-2-PENTENE;2-Pentene,5-bromo-2-methyl-;5-Bromo-2-methyl-2-pentene 97%;5-Bromo-2-methyl-2-pentene - [B0351];5-
Bromo- 2- methyl- 2- pentene - CBNumber
- CB6462772
- Molecular Formula
- C6H11Br
- Formula Weight
- 163.06
- MOL File
- 2270-59-9.mol
5-BROMO-2-METHYL-2-PENTENE Property
- Melting point:
- -102.35°C (estimate)
- Boiling point:
- 152-154 °C (lit.)
- Density
- 1.217 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.476(lit.)
- Flash point:
- 73 °F
- storage temp.
- 2-8°C
- form
- liquid
- Specific Gravity
- 1.217
- Appearance
- Colorless to light yellow Liquid
- Water Solubility
- Slightly miscible with water.
- BRN
- 1735749
- InChI
- InChI=1S/C6H11Br/c1-6(2)4-3-5-7/h4H,3,5H2,1-2H3
- InChIKey
- UNXURIHDFUQNOC-UHFFFAOYSA-N
- SMILES
- C/C(/C)=C\CCBr
Safety
- Hazard Codes
- Xi
- Risk Statements
- 10-36/37/38
- Safety Statements
- 26-36
- RIDADR
- UN 1993 3/PG 2
- WGK Germany
- 3
- F
- 10-23
- Hazard Note
- Irritant
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29033990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 262501
- Product name
- 5-Bromo-2-methyl-2-pentene
- Purity
- 97%
- Packaging
- 1g
- Price
- $61.32
- Updated
- 2025/07/31
- Product number
- 262501
- Product name
- 5-Bromo-2-methyl-2-pentene
- Purity
- 97%
- Packaging
- 5g
- Price
- $171.5
- Updated
- 2025/07/31
- Product number
- B6764
- Product name
- 5-Bromo-2-methylpent-2-ene
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $59
- Updated
- 2025/07/31
- Product number
- B6764
- Product name
- 5-Bromo-2-methylpent-2-ene
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $177
- Updated
- 2025/07/31
- Product number
- B686118
- Product name
- 5-Bromo-2-methyl-2-pentene
- Packaging
- 2.5g
- Price
- $285
- Updated
- 2021/12/16
5-BROMO-2-METHYL-2-PENTENE Chemical Properties,Usage,Production
Uses
5-Bromo-2-methyl-2-pentene acts as a synthetic reagent, which is useful in the formation of sesqueterpenoid. It is also employed in the preparation of geranlol-3-14C. Further, it is used in the preparation of penifulvin A, which is a sesquiterpenoid with a novel dioxa-fenestrane structure.
Synthesis
765-43-5
75-16-1
2270-59-9
1. 105 kg of THF solution of 12% methylmagnesium bromide (equivalent to 12.6 kg 100% concentration) was slowly added to a stainless steel reactor under brine bath cooling, maintaining the reaction temperature at 30-35°C. 2. 6.7 kg of cyclopropyl methyl ketone (II) was added dropwise to the reactor. 2. 6.7 kg of cyclopropyl methyl ketone (II) was added dropwise to the reactor, and after completion of the dropwise addition, the reaction mixture was stirred continuously at 30-35 °C for at least 1 hour. 3. the reaction mixture was cooled to 5-10 °C and then transferred to another enameled reactor pre-cooled to 0-10 °C containing 60 kg of 35% sulfuric acid. 4. the reaction mixture was warmed to 25-30 °C and maintained at this temperature for at least 15 minutes to ensure complete reaction. Subsequently, it was left to fully separate the two phases and remove the lower aqueous phase. 5. The organic phase was washed with 6.7 kg of softened water, stirred at 25-30 °C and left to stratify, again removing the lower aqueous phase. 6. Remove the solvent from the organic phase by vacuum distillation until an oily residue is obtained. To the residue was added 10.1 kg of THF and stirred until complete dissolution. 7. The resulting solution was transferred to a vessel of suitable capacity and prepared for the next stage of the reaction. 8. 8. 10 kg of the target product 5-bromo-2-methyl-2-pentene was finally obtained in 77% yield based on cyclopropyl methyl ketone (II).
References
[1] Chemistry - A European Journal, 2009, vol. 15, # 40, p. 10473 - 10485
[2] Organic and Biomolecular Chemistry, 2014, vol. 12, # 47, p. 9707 - 9715
[3] Organic Letters, 2006, vol. 8, # 24, p. 5421 - 5424
[4] European Journal of Organic Chemistry, 2006, # 14, p. 3181 - 3192
[5] Patent: US2009/43093, 2009, A1. Location in patent: Page/Page column 3
5-BROMO-2-METHYL-2-PENTENE Preparation Products And Raw materials
Raw materials
Preparation Products
5-BROMO-2-METHYL-2-PENTENE Suppliers
- Tel
- --
- Fax
- --
- labchem-tec@wako-chem.co.jp
- Country
- Japan
- ProdList
- 6819
- Advantage
- 80
View Lastest Price from 5-BROMO-2-METHYL-2-PENTENE manufacturers
- Product
- 5-BROMO-2-METHYL-2-PENTENE 2270-59-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-28
- Product
- 5-Bromo-2-methylpent-2-ene 2270-59-9
- Price
- US $2990.00/Kg
- Min. Order
- 0.100Kg
- Purity
- 97
- Supply Ability
- 500 Kg
- Release date
- 2024-09-06
- Product
- 5-Bromo-2-methyl-2-pentene 2270-59-9
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-01-13