H-GLY-TYR-PRO-GLY-GLN-VAL-OH

Product Name: H-GLY-TYR-PRO-GLY-GLN-VAL-OH
CAS No.: 225779-44-2
Chemical Name: H-GLY-TYR-PRO-GLY-GLN-VAL-OH
Synonyms: PAR 4 (1-6);PAR-4 (1-6) (HUMAN);GLY-TYR-PRO-GLY-GLN-VAL;H-GLY-TYR-PRO-GLY-GLN-VAL-OH;GYPGQV trifluoroacetate salt;Protease Activated Receptor-4 (1-6);PAR-4 AGONIST PEPTIDE (GYPGQV), HUMAN;H-GLY-TYR-PRO-GLY-GLN-VAL-OH USP/EP/BP;Gly-Tyr-Pro-Gly-Gln-Val trifluoroacetate salt;Glycyl-L-tyrosyl-L-prolylglycyl-L-glutaminyl-L-valine
CBNumber: CB6463254
Molecular Formula: C28H41N7O9
Formula Weight: 619.67
MOL File: 225779-44-2.mol

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H-GLY-TYR-PRO-GLY-GLN-VAL-OH Property

storage temp.: -15°C
solubility: H2O: >2mg/mL
form: powder
color: white to tan
Sequence: Gly-Tyr-Pro-Gly-Gln-Val

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27126
Product name: PAR4 (1-6) (human)
Packaging: 25mg
Price: $706
Updated: 2024/03/01

Cayman Chemical

Product number: 27126
Product name: PAR4 (1-6) (human)
Packaging: 50mg
Price: $1175
Updated: 2024/03/01

Cayman Chemical

Product number: 27126
Product name: PAR4 (1-6) (human)
Packaging: 5mg
Price: $158
Updated: 2024/03/01

Cayman Chemical

Product number: 27126
Product name: PAR4 (1-6) (human)
Packaging: 10mg
Price: $299
Updated: 2024/03/01

AK Scientific

Product number: 6221CR
Product name: (2S)-2-[[(2S)-5-Amino-2-[[2-[[(2S)-1-[(2S)-2-[(2-aminoacetyl)amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-3-methylbutanoicacid
Packaging: 5mg
Price: $274
Updated: 2021/12/16

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H-GLY-TYR-PRO-GLY-GLN-VAL-OH Chemical Properties,Usage,Production

Description

PAR4 (1-6) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR4 and residues 48-53 of the full-length sequence. It activates PAR4 and the cleavage site mutant PAR4^R47A when used at a concentration of 500 μM. PAR4 (1-6) induces platelet aggregation of isolated washed human platelets when used at a concentration of 1 mM but does not affect clotting time induced by factor VIIa, soluble tissue factor, and collagen in an ex vivo coagulation assay.

Uses

PAR 4 (1-6) human, a hexapeptide, is a fragment of protease-activated receptor 4 (PAR4). PAR 4 (1-6) TFA acts as a PAR4-specific agonist[1].

References

[1] H Andersen, et al. Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11189-93. DOI:10.1073/pnas.96.20.11189
[2] E Bretschneider, et al. Evidence for functionally active protease-activated receptor-4 (PAR-4) in human vascular smooth muscle cells. Br J Pharmacol. 2001 Apr;132(7):1441-6. DOI:10.1038/sj.bjp.0703947

H-GLY-TYR-PRO-GLY-GLN-VAL-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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H-GLY-TYR-PRO-GLY-GLN-VAL-OH Suppliers

China 74 France 1 United Kingdom 1 United States 9 Global 85

3B Pharmachem (Wuhan) International Co.,Ltd.

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Shanghai Hanhong Scientific Co.,Ltd.

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Nanjing Leon Biological Technology Co., Ltd.

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Nanjing Peptide Biotech Ltd.

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Chengdu Youngshe Chemical Co., Ltd.

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View Lastest Price from H-GLY-TYR-PRO-GLY-GLN-VAL-OH manufacturers

Career Henan Chemical Co

Product: H-GLY-TYR-PRO-GLY-GLN-VAL-OH 225779-44-2
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2020-02-13

225779-44-2, H-GLY-TYR-PRO-GLY-GLN-VAL-OHRelated Search:

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 PAR-4 (1-6) amide (human) H-SER-LEU-ILE-GLY-ARG-LEU-NH2 COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) AMIDE (HUMAN) COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) AMIDE (MOUSE) (PHE1,SER2,TYR6)-PAR-1 (1-6) AMIDE (HUMAN) H-SER-LEU-ILE-GLY-ARG-LEU-OH H-GLY-TYR-PRO-GLY-LYS-PHE-NH2 VKGILS-NH2 H-GLY-TYR-PRO-GLY-GLN-VAL-OH H2N-AYPGQV-OH

GLY-TYR-PRO-GLY-GLN-VAL

H-GLY-TYR-PRO-GLY-GLN-VAL-OH

PROTEINASE ACTIVATED RECEPTOR 4 AGONIST PEPTIDE (GYPGQV), HUMAN

PAR-4 AGONIST PEPTIDE (GYPGQV), HUMAN

PAR-4 (1-6) (HUMAN)

PAR 4 (1-6)

GYPGQV, Coagulation Factor II Receptor-Like 3 (1-6) (huMan), Proteinase Activated Receptor 4 (1-6) (huMan), ThroMbin Receptor-Like 3 (1-6) (huMan)

Glycyl-L-tyrosyl-L-prolyl-glycyl-L-glutaminyl-L-valine trifluoroacetate salt

Gly-Tyr-Pro-Gly-Gln-Val trifluoroacetate salt

GYPGQV trifluoroacetate salt

L-Valine, glycyl-L-tyrosyl-L-prolylglycyl-L-glutaminyl-

Glycyl-L-tyrosyl-L-prolylglycyl-L-glutaminyl-L-valine

H-GLY-TYR-PRO-GLY-GLN-VAL-OH USP/EP/BP

PAR-4 (1-6) (human) trifluoroacetate salt H-Gly-Tyr-Pro-Gly-Gln-Val-OH trifluoroacetate salt

Protease Activated Receptor-4 (1-6)

225779-44-2

C28H41N7O9