ChemicalBook > CAS DataBase List > H-GLY-TYR-PRO-GLY-GLN-VAL-OH

H-GLY-TYR-PRO-GLY-GLN-VAL-OH

Product Name
H-GLY-TYR-PRO-GLY-GLN-VAL-OH
CAS No.
225779-44-2
Chemical Name
H-GLY-TYR-PRO-GLY-GLN-VAL-OH
Synonyms
PAR 4 (1-6);PAR-4 (1-6) (HUMAN);GLY-TYR-PRO-GLY-GLN-VAL;H-GLY-TYR-PRO-GLY-GLN-VAL-OH;GYPGQV trifluoroacetate salt;Protease Activated Receptor-4 (1-6);PAR-4 AGONIST PEPTIDE (GYPGQV), HUMAN;H-GLY-TYR-PRO-GLY-GLN-VAL-OH USP/EP/BP;Gly-Tyr-Pro-Gly-Gln-Val trifluoroacetate salt;Glycyl-L-tyrosyl-L-prolylglycyl-L-glutaminyl-L-valine
CBNumber
CB6463254
Molecular Formula
C28H41N7O9
Formula Weight
619.67
MOL File
225779-44-2.mol
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H-GLY-TYR-PRO-GLY-GLN-VAL-OH Property

storage temp. 
-15°C
solubility 
H2O: >2mg/mL
form 
powder
color 
white to tan
Sequence
Gly-Tyr-Pro-Gly-Gln-Val
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27126
Product name
PAR4 (1-6) (human)
Packaging
25mg
Price
$706
Updated
2024/03/01
Cayman Chemical
Product number
27126
Product name
PAR4 (1-6) (human)
Packaging
50mg
Price
$1175
Updated
2024/03/01
Cayman Chemical
Product number
27126
Product name
PAR4 (1-6) (human)
Packaging
5mg
Price
$158
Updated
2024/03/01
Cayman Chemical
Product number
27126
Product name
PAR4 (1-6) (human)
Packaging
10mg
Price
$299
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
PEP0005613
Product name
GLY-TYR-PRO-GLY-GLN-VAL
Purity
95.00%
Packaging
5MG
Price
$497.99
Updated
2021/12/16
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H-GLY-TYR-PRO-GLY-GLN-VAL-OH Chemical Properties,Usage,Production

Description

PAR4 (1-6) is a peptide agonist of proteinase-activated receptor 4 (PAR4) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR4 and residues 48-53 of the full-length sequence. It activates PAR4 and the cleavage site mutant PAR4R47A when used at a concentration of 500 μM. PAR4 (1-6) induces platelet aggregation of isolated washed human platelets when used at a concentration of 1 mM but does not affect clotting time induced by factor VIIa, soluble tissue factor, and collagen in an ex vivo coagulation assay.

Uses

PAR 4 (1-6) human, a hexapeptide, is a fragment of protease-activated receptor 4 (PAR4). PAR 4 (1-6) TFA acts as a PAR4-specific agonist[1].

References

[1] H Andersen, et al. Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11189-93. DOI:10.1073/pnas.96.20.11189
[2] E Bretschneider, et al. Evidence for functionally active protease-activated receptor-4 (PAR-4) in human vascular smooth muscle cells. Br J Pharmacol. 2001 Apr;132(7):1441-6. DOI:10.1038/sj.bjp.0703947

H-GLY-TYR-PRO-GLY-GLN-VAL-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from H-GLY-TYR-PRO-GLY-GLN-VAL-OH manufacturers

Career Henan Chemical Co
Product
H-GLY-TYR-PRO-GLY-GLN-VAL-OH 225779-44-2
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2020-02-13

225779-44-2, H-GLY-TYR-PRO-GLY-GLN-VAL-OHRelated Search:

H-ALA-TYR-PRO-GLY-LYS-PHE-NH2 PAR-4 (1-6) amide (human) H-SER-LEU-ILE-GLY-ARG-LEU-NH2 COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) AMIDE (HUMAN) COAGULATION FACTOR II RECEPTOR-LIKE 2 (1-6) AMIDE (MOUSE) (PHE1,SER2,TYR6)-PAR-1 (1-6) AMIDE (HUMAN) H-SER-LEU-ILE-GLY-ARG-LEU-OH H-GLY-TYR-PRO-GLY-LYS-PHE-NH2 VKGILS-NH2 H-GLY-TYR-PRO-GLY-GLN-VAL-OH H2N-AYPGQV-OH

  • GLY-TYR-PRO-GLY-GLN-VAL
  • H-GLY-TYR-PRO-GLY-GLN-VAL-OH
  • PROTEINASE ACTIVATED RECEPTOR 4 AGONIST PEPTIDE (GYPGQV), HUMAN
  • PAR-4 AGONIST PEPTIDE (GYPGQV), HUMAN
  • PAR-4 (1-6) (HUMAN)
  • PAR 4 (1-6)
  • GYPGQV, Coagulation Factor II Receptor-Like 3 (1-6) (huMan), Proteinase Activated Receptor 4 (1-6) (huMan), ThroMbin Receptor-Like 3 (1-6) (huMan)
  • Glycyl-L-tyrosyl-L-prolyl-glycyl-L-glutaminyl-L-valine trifluoroacetate salt
  • Gly-Tyr-Pro-Gly-Gln-Val trifluoroacetate salt
  • GYPGQV trifluoroacetate salt
  • L-Valine, glycyl-L-tyrosyl-L-prolylglycyl-L-glutaminyl-
  • Glycyl-L-tyrosyl-L-prolylglycyl-L-glutaminyl-L-valine
  • H-GLY-TYR-PRO-GLY-GLN-VAL-OH USP/EP/BP
  • PAR-4 (1-6) (human) trifluoroacetate salt H-Gly-Tyr-Pro-Gly-Gln-Val-OH trifluoroacetate salt
  • Protease Activated Receptor-4 (1-6)
  • 225779-44-2
  • C28H41N7O9