Iodixanol
- Product Name
- Iodixanol
- CAS No.
- 92339-11-2
- Chemical Name
- Iodixanol
- Synonyms
- OptiPrep;Visipaque;DU-6807;Ioxanol;Ioxaxol;odixanol;Acupaque;lodoanol;IODIXANOL;2-5410-3A
- CBNumber
- CB6465056
- Molecular Formula
- C35H44I6N6O15
- Formula Weight
- 1550.18
- MOL File
- 92339-11-2.mol
Iodixanol Property
- Melting point:
- 262-267°C (dec.)
- Boiling point:
- 1250.9±65.0 °C(Predicted)
- Density
- 1.266 ±0.003
- vapor pressure
- 0Pa at 20℃
- refractive index
- n 1.4128 ±0.0003
- storage temp.
- Refrigerator
- solubility
- Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride.
- pka
- 11.04±0.46(Predicted)
- color
- White
- LogP
- 0.7
- EPA Substance Registry System
- 1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- (92339-11-2)
Safety
- HS Code
- 2924296000
- Hazardous Substances Data
- 92339-11-2(Hazardous Substances Data)
- Toxicity
- LD50 i.v. in mice: 21 gI/kg (Palmers)
N-Bromosuccinimide Price
- Product number
- Y0001294
- Product name
- Iodixanol
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001294
- Price
- $220
- Updated
- 2024/03/01
- Product number
- PHR3015
- Product name
- Iodixanol
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 500MG
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 1343517
- Product name
- Iodixanol
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- I667200
- Product name
- Iodixanol
- Packaging
- 100mg
- Price
- $1165
- Updated
- 2021/12/16
- Product number
- API0007294
- Product name
- IODIXANOL (60% SOLUTION IN WATER)
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $12400
- Updated
- 2021/12/16
Iodixanol Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
OptiPrep,Nycomed Pharma,Norway
Uses
Nonionic, dimeric x-ray contrast medium. Diagnostic aid (radiopaque medium).
Definition
ChEBI: A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.
Manufacturing Process
Dimethyl 5-nitroisophthalate (215 g) and 1-amino-2,3-propandiol (196 g)were refluxed in methanol (500 ml). After twenty hours the solution was
cooled and stored in a refrigerator overnight. The product 5-nitro-N,N'-
bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with
methanol. Yield: 270 g (84%). M.p. 128-132°C.
5-Nitro-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (18.1 g) was suspended
in water (250 ml), conc. hydrochloric acid (4.2 ml) and 10% PdO/charcoal
(0.5 g) were added, and the mixture hydrogenated in a Parr apparatus for one
day. After filtration the filtrate was heated at 80-90°C and 3.88 M NaICl2
(42.5 ml) was added through a dropping funnel over 1 hour. The solution was
heated for 2.5 hours. After cooling to 20°C 5-amino-2,4,6-triiodo-N,N'-
bis(2,3-dihydroxypropyl)-isophthalamide crystallized out.
5-Amino-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (110 g)
was suspended in acetic anhydride (480 ml) and heated to 50°C.
Concentrated sulfuric acid (3 ml) was then added. The starting material was
dissolved after a few minutes, and the reaction mixture was heated at 60°C
for 75 min. After cooling the residue dissolved in methanol (300 ml) with
water (150 ml) the solution was heated to 50°C and the pH adjusted to about
10.5 by 10 N sodium hydroxide. After 4-5 hours the pH didn't decrease, and
the hydrolysis was complete. The reaction mixture was cooled to 20°C and
neutralized by adding hydrochloric acid. After stirring overnight 5-Acetamido-
2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide was filtered and
washed with water. Yield: 94 g (80%). Melting point 275°C, dec.
2-Methoxyethanol (300 ml) and sodium hydroxide (20 g) was added to the
reactor at 50°C, and 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-
triiodoisophtalamide (304 g) was added after two hours of stirring. All solids
were allowed to dissolve overnight before cooling to 30°C and adjustment to
pH 12 with diluted hydrochloric acid. Epichlorohydrin (11 g) was added to the
solution after further cooling to 15°C, and the reaction was allowed to proceed
for 51 hours. As a result 1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3-
dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane was
obtained.
brand name
Visipaque (GE Healthcare).
Therapeutic Function
Diagnostic aid
General Description
Iodixanol is a viscous, isosmolar,nonionic, water-soluble dimer with 49% iodine content.It is formulated as an isotonic solution for intravascular injectionand indicated for excretory urography, angiography,and CT procedures.
Iodixanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Iodixanol manufacturers
- Product
- Iodixanol 92339-11-2
- Price
- US $80.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2023-04-23
- Product
- Iodixanol 92339-11-2
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 98.6%~101.0%; USP37
- Supply Ability
- 2000kg/month
- Release date
- 2021-06-23
- Product
- Iodixanol 92339-11-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-28