Iodixanol
- Product Name
- Iodixanol
- CAS No.
- 92339-11-2
- Chemical Name
- Iodixanol
- Synonyms
- OptiPrep;Visipaque;DU-6807;Ioxanol;Ioxaxol;odixanol;Acupaque;lodoanol;IODIXANOL;2-5410-3A
- CBNumber
- CB6465056
- Molecular Formula
- C35H44I6N6O15
- Formula Weight
- 1550.18
- MOL File
- 92339-11-2.mol
Iodixanol Property
- Melting point:
- 262-267°C (dec.)
- Boiling point:
- 1250.9±65.0 °C(Predicted)
- Density
- 1.266 ±0.003
- vapor pressure
- 0Pa at 20℃
- refractive index
- n 1.4128 ±0.0003
- storage temp.
- Refrigerator
- solubility
- Freely soluble in water, sparingly soluble in methanol, practically insoluble in methylene chloride.
- pka
- 11.04±0.46(Predicted)
- color
- White
- LogP
- 0.7
- EPA Substance Registry System
- 1,3-Benzenedicarboxamide, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(acetylimino)]bis[N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo- (92339-11-2)
Safety
- HS Code
- 2924296000
- Hazardous Substances Data
- 92339-11-2(Hazardous Substances Data)
- Toxicity
- LD50 i.v. in mice: 21 gI/kg (Palmers)
N-Bromosuccinimide Price
- Product number
- Y0001294
- Product name
- Iodixanol
- Purity
- European Pharmacopoeia (EP) Reference Standard
- Packaging
- y0001294
- Price
- $220
- Updated
- 2024/03/01
- Product number
- PHR3015
- Product name
- Iodixanol
- Purity
- pharmaceutical secondary standard, certified reference material
- Packaging
- 500MG
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 1343517
- Product name
- Iodixanol
- Packaging
- 200mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- I667200
- Product name
- Iodixanol
- Packaging
- 100mg
- Price
- $1165
- Updated
- 2021/12/16
- Product number
- API0007294
- Product name
- IODIXANOL (60% SOLUTION IN WATER)
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $12400
- Updated
- 2021/12/16
Iodixanol Chemical Properties,Usage,Production
Chemical Properties
White Solid
Originator
OptiPrep,Nycomed Pharma,Norway
Uses
Nonionic, dimeric x-ray contrast medium. Diagnostic aid (radiopaque medium).
Definition
ChEBI: A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.
Manufacturing Process
Dimethyl 5-nitroisophthalate (215 g) and 1-amino-2,3-propandiol (196 g)were refluxed in methanol (500 ml). After twenty hours the solution was
cooled and stored in a refrigerator overnight. The product 5-nitro-N,N'-
bis(2,3-dihydroxypropyl)-isophthalamide was filtered and washed with
methanol. Yield: 270 g (84%). M.p. 128-132°C.
5-Nitro-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (18.1 g) was suspended
in water (250 ml), conc. hydrochloric acid (4.2 ml) and 10% PdO/charcoal
(0.5 g) were added, and the mixture hydrogenated in a Parr apparatus for one
day. After filtration the filtrate was heated at 80-90°C and 3.88 M NaICl2
(42.5 ml) was added through a dropping funnel over 1 hour. The solution was
heated for 2.5 hours. After cooling to 20°C 5-amino-2,4,6-triiodo-N,N'-
bis(2,3-dihydroxypropyl)-isophthalamide crystallized out.
5-Amino-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide (110 g)
was suspended in acetic anhydride (480 ml) and heated to 50°C.
Concentrated sulfuric acid (3 ml) was then added. The starting material was
dissolved after a few minutes, and the reaction mixture was heated at 60°C
for 75 min. After cooling the residue dissolved in methanol (300 ml) with
water (150 ml) the solution was heated to 50°C and the pH adjusted to about
10.5 by 10 N sodium hydroxide. After 4-5 hours the pH didn't decrease, and
the hydrolysis was complete. The reaction mixture was cooled to 20°C and
neutralized by adding hydrochloric acid. After stirring overnight 5-Acetamido-
2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)-isophthalamide was filtered and
washed with water. Yield: 94 g (80%). Melting point 275°C, dec.
2-Methoxyethanol (300 ml) and sodium hydroxide (20 g) was added to the
reactor at 50°C, and 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-
triiodoisophtalamide (304 g) was added after two hours of stirring. All solids
were allowed to dissolve overnight before cooling to 30°C and adjustment to
pH 12 with diluted hydrochloric acid. Epichlorohydrin (11 g) was added to the
solution after further cooling to 15°C, and the reaction was allowed to proceed
for 51 hours. As a result 1,3-bis(acetamido)-N,N'-bis[3,5-bis(2,3-
dihydroxypropylaminocarbonyl)-2,4,6-triiodophenyl]-2-hydroxypropane was
obtained.
brand name
Visipaque (GE Healthcare).
Therapeutic Function
Diagnostic aid
General Description
Iodixanol is a viscous, isosmolar,nonionic, water-soluble dimer with 49% iodine content.It is formulated as an isotonic solution for intravascular injectionand indicated for excretory urography, angiography,and CT procedures.
Iodixanol Preparation Products And Raw materials
Raw materials
Preparation Products
Iodixanol Suppliers
View Lastest Price from Iodixanol manufacturers
- Product
- Iodixanol 92339-11-2
- Price
- US $80.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2023-04-23
- Product
- Iodixanol 92339-11-2
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 98.6%~101.0%; USP37
- Supply Ability
- 2000kg/month
- Release date
- 2021-06-23
- Product
- Iodixanol 92339-11-2
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-08-28