ChemicalBook > CAS DataBase List > 5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
- Product Name
- 5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
- CAS No.
- 99632-94-7
- Chemical Name
- 5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
- Synonyms
- RO 19-4603;Ro 194603,Ro 19 4603;5,6-Dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylicacid1,1-dimethylethylester;5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER;4H-Imidazo[1,5-a]thieno[2,3-f][1,4]diazepine-3-carboxylic acid, 5,6-dihydro-5-methyl-6-oxo-, 1,1-dimethylethyl ester
- CBNumber
- CB6465061
- Molecular Formula
- C15H17N3O3S
- Formula Weight
- 319.38
- MOL File
- 99632-94-7.mol
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5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Property
- storage temp.
- Store at RT
- solubility
- <31.94mg/ml in ethanol; <31.94mg/ml in DMSO
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N-Bromosuccinimide Price
Usbiological
- Product number
- 256477
- Product name
- Ro 19-4603
- Packaging
- 10mg
- Price
- $409
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0972477
- Product name
- 5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.41
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B6913
- Product name
- Ro19-4603
- Packaging
- 50mg
- Price
- $1053
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B6913
- Product name
- Ro19-4603
- Packaging
- 10mg
- Price
- $251
- Updated
- 2021/12/16
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5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Chemical Properties,Usage,Production
Uses
Ro 19-4603 is a novel benzodiazepine inverse agonist.
Definition
ChEBI: Ro 19-4603 is an organonitrogen heterocyclic compound, an organosulfur heterocyclic compound and a tert-butyl ester.
Biological Activity
Benzodiazepine inverse agonist. Binds with high affinity to both diazepam-sensitive (DS) and diazepam-insensitive (DI) GABA A receptors (K i values are ~ 0.2 and ~ 2.6 nM for DS and DI receptors respectively). Antagonizes effects of ethanol on locomotor behavior and suppresses ethanol intake in alcohol-preferring rats.
in vivo
Ro19-4603 (0-0.3 mg/kg, i.p.) markedly reduces EtOH intake at the 8-h interval in alcohol-preferring rats[1].
| Animal Model: | Alcohol-Preferring rats[1] |
| Dosage: | 0.075, 0.150, and 0.30 mg/kg. |
| Administration: | i.p. |
| Result: | Reduced EtOH intake at the 8-h interval, but no apparent effect at the 24-h interval. |
5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER Suppliers
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99632-94-7, 5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTERRelated Search:
(1-METHYL-1H-IMIDAZOL-4-YL)METHANOL
1-Methyl-1H-imidazole-4-carboxylic acid
1,5-DIMETHYL-1H-IMIDAZOLE-4-CARBALDEHYDE
1-METHYL-1H-IMIDAZOLE-4-CARBOXYLIC ACID METHYL ESTER
5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]THIENO[2,3-F][1,4]DIAZEPINE-3-CARBOXYLIC ACID 1,1-DIMETHYLETHYL ESTER