5-Azacytosine

Product Name: 5-Azacytosine
CAS No.: 931-86-2
Chemical Name: 5-Azacytosine
Synonyms: 4-aMino-1,3,5-triazin-2-ol;4-amino-1,3,5-triazin-2(1h)-one;AZACYTOSINE;NSC 51100;NSC 54006;5-Azacytosin;5 zacytosine;5-AZACYTOSINE;5-Azacytosine,98%;5-Azacytosine API
CBNumber: CB6465182
Molecular Formula: C3H4N4O
Formula Weight: 112.09
MOL File: 931-86-2.mol

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5-Azacytosine Property

Melting point:: >300 °C (lit.)
Boiling point:: 209.98°C (rough estimate)
Density: 1.86
refractive index: 1.8010 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated)
form: Solid
pka: 7.61±0.10(Predicted)
color: White to Off-White
BRN: 116378
InChI: InChI=1S/C3H4N4O/c4-2-5-1-6-3(8)7-2/h1H,(H3,4,5,6,7,8)
InChIKey: MFEFTTYGMZOIKO-UHFFFAOYSA-N
SMILES: N1C(N)=NC=NC1=O
CAS DataBase Reference: 931-86-2(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 3
RTECS: XZ2854300
HS Code: 29336990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3473
Product name: Azacitidine Related Compound A
Purity: certified reference material, pharmaceutical secondary standard
Packaging: 50MG
Price: $651
Updated: 2025/07/31

Sigma-Aldrich

Product number: 855049
Product name: 5-Azacytosine
Packaging: 5g
Price: $80.37
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1045539
Product name: Azacitidine Related Compound A
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25mg
Price: $1300
Updated: 2025/07/31

TCI Chemical

Product number: A1091
Product name: 5-Azacytosine Hydrate
Purity: >98.0%(T)
Packaging: 5g
Price: $59
Updated: 2025/07/31

TCI Chemical

Product number: A1091
Product name: 5-Azacytosine Hydrate
Purity: >98.0%(T)
Packaging: 25g
Price: $236
Updated: 2025/07/31

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5-Azacytosine Chemical Properties,Usage,Production

Chemical Properties

Crystalline Solid

Uses

Reactant for:

Enzymic synthesis of nucleoside analogs using immobilized 2′-deoxyribosyltransferase from Lactobacillus reuteri
Reactions with oxide radical ion

Potential antitumor and antiproliferative agent against human leukemia cells

Uses

5-Azacytosine can inhibits the growth of Escherichia coli and used as the most effective cytosine mimics for the design of novel antiviral and anti-tumor drug candidates.

Definition

ChEBI: A monoamino-1,3,5-triazine that is cytosine in which the aromatic CH at position 5 is replaced by a nitrogen.

Synthesis

64-18-6

127099-85-8

931-86-2

(1) Add 1.5Kg of anhydrous formic acid (99.5% purity), 2.5kg of dicyandiamide and 0.005Kg of p-toluenesulfonic acid catalyst to a 10L autoclave. Under the condition of sealing and stirring, the reaction system was slowly warmed up to 110°C and the reaction pressure was maintained. After the reaction was completed, the temperature was slowly cooled down to room temperature to obtain a white solid product. (2) The resulting white solid was transferred to a 50L glass reactor and 10L of dilute hydrochloric acid solution with a mass concentration of 5% was added. Heating was refluxed for 30 minutes until the solution was clarified. Subsequently, the mixture was filtered through a cartridge into a crystallizer. A 30% ammonia solution was added to the crystallizer and the pH was adjusted to 6. White crystals were precipitated. After centrifugation and drying in a hot air oven, 2.8-5 kg of 6-amino-1,3,5-triazin-2(1H)-one (85% yield as dicyandiamide) was finally obtained.

References

[1] Patent: CN105837524, 2016, A. Location in patent: Paragraph 0042; 0043; 0044; 0045; 0046; 0047; 0048-0079
[2] Chemische Berichte, 1954, vol. 87, p. 19,23
[3] Archiv der Pharmazie (Weinheim, Germany), 1955, vol. 288, p. 139
[4] Patent: CN104402836, 2016, B. Location in patent: Paragraph 0025; 0026; 0027; 0028

5-Azacytosine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Azacytosine Suppliers

Americas 1 Belgium 2 Canada 1 China 482 Europe 3 Germany 11 India 43 Japan 2 Slovakia 1 Switzerland 4 United Kingdom 20 United States 43 Global 613

Lianyungang Shenghe Biotechnology Co., Ltd.

Tel: 13585296001 13585296001
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Shandong Shenghe Pharmaceutical Technology Co. LTD

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J & K SCIENTIFIC LTD.

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INTATRADE GmbH

Tel: +49 3493/605464
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3B Pharmachem (Wuhan) International Co.,Ltd.

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Alfa Aesar

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TCI (Shanghai) Development Co., Ltd.

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ShangHai DEMO Chemical Co.,Ltd

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Wuhan Chemwish Technology Co., Ltd

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View Lastest Price from 5-Azacytosine manufacturers

Xinxiang Aurora Biotechnology Co.,Ltd.

Product: 5-azacytosine 931-86-2
Price: US $99.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20Ton
Release date: 2025-10-10

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: 5-Azacytosine 931-86-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tons
Release date: 2025-08-31

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 5-Azacytosine 931-86-2
Price: US $2.00-6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-07-29

931-86-2, 5-AzacytosineRelated Search:

4-Aminoacetophenone ANILAZINE 5-METHYLCYTOSINE Toltrazuril beta-Methyl vinyl phosphate (MAP) CHLOROPHOSPHONAZO III 3-Aminoacetophenone ALTRENOGEST Cytosine Metribuzin Fluorocytosine Betaine 2-Aminoacetophenone Glycine 1,3,5-Triazine Buprofezin 5-Azacytidine / 5-Azacytosine 5-Aza-2'-deoxycytidine

5-triazin-2(1h)-one,4-amino-3

2-Amino-4-hydroxy-1,3,5-triazine

2-AMINO-4-HYDROXY-S-TRIAZINE

4-AMINO-1,3,5-TRIAZIN-2-ONE

4-AMINO-1,3,5-TRIAZINE-2[1H]-ONE

4-AMINO-S-TRIAZIN-2(1H)-ONE

5-AZACYTOSINE

5-Azacytosine,98%

AZACYTOSINE

4-amino-s-triazin-2-o

NSC 51100

NSC 54006

5-Azacytosine API

2-Amino-4-hydroxy-1,3,5-triazine 4-Amino-1,3,5-triazin-2(1H)-one

2-AMino-4-hydroxy-1,3,5-triazin

AZACYTOSINE, 5-(RG)

4-aMino-1,3,5-triazin-2-ol

4-aMino-1,2-dihydro-1,3,5-triazin-2-one

4-Aino-[1,3,5]triazin-2-ol

5-aza-cytosine, 4-aMino-1,2-dihydro-1,3,5-triazin-2-one, 5-azacytosine

5-Azacytosine&nbsp

5-Azacytosine, 98+% 5GR

1,3,5-Triazin-2(1H)-one, 4-aMino- (9CI)

s-Triazin-2(1H)-one, 4-aMino- (8CI)

Azacitidine Related CoMpound A

Azacitidine Related Compound A (15 mg) (4-Amino-1,3,5-triazin-2(1H)-one)

Azacitidine Related Compound C (15 mg) (1-beta-D-Ribofuranosyl-3-guanylurea picrate)

5-Azacytosine(2-amino-4-hydroxy-1,3,5-triazine)

Cytosine Impurity 1

Decitabine Impurity 49

Azacitidine USP Related Compound A

Azacetidine Related Compound A (Hydrate)

5-AZACYTOSINE (DRY WT.), MAY CONT. UP TO CA 7% WATER

6-Amino-1H-[1,3,5]triazin-2-one

4-Amino-1H-[1,3,5]triazin-2-one

5-Azacytosine, 98% (dry wt.), may cont. up to ca 7% water

5-Azacytosine Hydrate

2-Hydroxy-4-aminotriazine

4-Amino-2-hydroxy-1,3,5-triazine

4-Amino-2-triazin-2(1H)-one

4-Amino-3H-1,3,5-triazin-2-one

4-Amino-s-triazin-2-ol

4(1H)-Imino-1,3,5-triazine-2-ol

4(3H)-Imino-1,3,5-triazine-2(1H)-one

4(5H)-Imino-1,3,5-triazine-2(3H)-one

4-Amino-1,3,5-triazine-2(3H)-one

4-Amino-1,3,5-triazine-2-ol

4-amino-1,3,5-triazin-2(1h)-one

4-amino-s-triazin-2(1h)-on

5-Azacytosine Hydrate&gt

Decitabine Impurity 49 (5-Azacytosine)

1,3,5-Triazin-2(1H)-one, 6-amino-

5-Azacytosine ISO 9001：2015 REACH

Decitabine Triazinone Impurity (Azacitidine Related Compound A/ 5-Aza Cytosine)

Azacitidine Related Compound A (5-Aza Cytosine/ Decitabine Triazinone Impurity)

1,3,5-Triazin-2(1H)-one, 4-amino-

5-AzacytosineQ: What is 5-Azacytosine Q: What is the CAS Number of 5-Azacytosine Q: What is the storage condition of 5-Azacytosine Q: What are the applications of 5-Azacytosine

4-Amino-1,3,5-triazin-2(5H)-one