RP 001 (hydrochloride)
- Product Name
- RP 001 (hydrochloride)
- CAS No.
- 1781880-34-9
- Chemical Name
- RP 001 (hydrochloride)
- Synonyms
- RP001 hydrochloride,RP 001 hydrochloride;N-[4-[5-[3-cyano-4-(1-methylethoxy)phenyl]-1,2,4-oxadiazol-3-yl]-2,3-dihydro-1H-inden-1-yl]-β-alanine,monohydrochloride
- CBNumber
- CB64666596
- Molecular Formula
- C24H25ClN4O4
- Formula Weight
- 468.94
- MOL File
- 1781880-34-9.mol
RP 001 (hydrochloride) Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: 100 mM
- form
- A solid
N-Bromosuccinimide Price
- Product number
- 16636
- Product name
- RP 001 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 16636
- Product name
- RP 001 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $161
- Updated
- 2024/03/01
- Product number
- 16636
- Product name
- RP 001 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $249
- Updated
- 2024/03/01
- Product number
- 16636
- Product name
- RP 001 (hydrochloride)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $530
- Updated
- 2024/03/01
- Product number
- R700988
- Product name
- RP001Hydrochloride
- Packaging
- 50mg
- Price
- $975
- Updated
- 2021/12/16
RP 001 (hydrochloride) Chemical Properties,Usage,Production
Description
RP 001 is a potent sphingosine-1-phosphate receptor 1 (S1P1) agonist (EC50 = 9 pM). It is competitive with W146 , a selective S1P1 antagonist, and induces internalization and polyubiquitination of S1P1 in a dose-dependent manner. RP 001 induces dose-dependent lymphopenia in mice (EC50 = 0.03 mg/kg). It reduces S1P1-EGFP expression ex vivo on lymphocytes in the isolated lymph node of Edg1eGFP/eGFP mice but has no effect in vivo. RP 001 also completely inhibits M. stadtmanae (MSS) rechallenge-induced enlargement of B cell-rich tertiary lymphoid tissues (TLTs) and reduces neutrophil accumulation in the airways of a mouse model of experimental hypersensitivity pneumonitis.
Uses
RP 001 Hydrochloride is a picomolar, short-acting S1P1 agonist.
storage
Store at -20°C
RP 001 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
RP 001 (hydrochloride) Suppliers
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