NAcM-OPT

Product Name: NAcM-OPT
CAS No.: 2089293-61-6
Chemical Name: NAcM-OPT
Synonyms: NAcM-OPT; NAcM-OPT NEW;Urea, N-(1-butyl-4-piperidinyl)-N'-(3,4-dichlorophenyl)-N-(phenylmethyl)-;E3 ligating enzyme,Ubiquitin activating enzyme,inhibit,NAcM-OPT,NAE,Ubiquitin conjugating enzyme,NAcMOPT,Ubiquitin ligase,NEDD8-activating Enzyme,E1 activating enzyme,E2 conjugating enzyme,Inhibitor,NAcM OPT,E1/E2/E3 Enzyme
CBNumber: CB64668257
Molecular Formula: C23H29Cl2N3O
Formula Weight: 434.4
MOL File: 2089293-61-6.mol

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NAcM-OPT Property

Boiling point:: 589.8±50.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml)
pka: 13.30±0.70(Predicted)
form: solid
color: White
Stability:: Stable for 1 year as from date of purchase supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: N633053
Product name: NAcM-OPT
Packaging: 10mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BN165240
Product name: NAcM-OPT NEW
Packaging: 10mg
Price: $85
Updated: 2021/12/16

ChemScene

Product number: CS-0042279
Product name: NAcM-OPT
Purity: 98.60%
Packaging: 10mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: 2411EJ
Product name: NAcM-OPT
Packaging: 10mg
Price: $164
Updated: 2021/12/16

ChemScene

Product number: CS-0042279
Product name: NAcM-OPT
Purity: 98.60%
Packaging: 50mg
Price: $270
Updated: 2021/12/16

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NAcM-OPT Chemical Properties,Usage,Production

Description

NAcM-OPT (2089293-61-6) is a potent and selective NEDD8 ligation inhibitor, IC50=80 nM (in vitro).1? It inhibits the N-terminal acetyl-dependent interaction between the E2 conjugating enzyme UBE2M/UBC12 and DCN1, a subunit of a multiprotein E3 ligase for the ubiquitin-like protein NEDD8, an interaction which is essential for assembly of the multiprotein ligation complex.2 NAcM-OPT inhibits NEDD8 ligation in vitro and in cells (IC50=10 μM) and suppresses anchorage-independent growth of HCC95 cells and is highly selective with respect to other N-terminal acetyl protein binding sites.1

Uses

NAcM-OPT inhibits N-Acetyl-mediated interaction between BE2M (E2 conjugating enzyme) and DCN1 (a component of E3 ligase complex). Also has inhibitory action on DCN2 and NEDD8 ubiquitin-like protein. Reduces anchorage-independent growth in DCN1-amplified cell line.

Definition

ChEBI: 1-Benzyl-1-(1-butyl-4-piperidinyl)-3-(3,4-dichlorophenyl)urea is a member of ureas.

References

1) Scott et al. (2017), Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase; Nat. Chem. Biol., 13 850 2) Scott et al. (2011), N-terminal acetylation acts as an avidity enhancer within an interconnected multiprotein complex; Science, 334 674

NAcM-OPT Preparation Products And Raw materials

Raw materials

Preparation Products

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NAcM-OPT Suppliers

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2089293-61-6, NAcM-OPTRelated Search:

b-AP15 SMER 3 1-[1-(4-Fluorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-(1-pyrrolidinyl)ethanone Carfilzomib

NAcM-OPT

NAcM-OPT NEW

Urea, N-(1-butyl-4-piperidinyl)-N'-(3,4-dichlorophenyl)-N-(phenylmethyl)-

E3 ligating enzyme,Ubiquitin activating enzyme,inhibit,NAcM-OPT,NAE,Ubiquitin conjugating enzyme,NAcMOPT,Ubiquitin ligase,NEDD8-activating Enzyme,E1 activating enzyme,E2 conjugating enzyme,Inhibitor,NAcM OPT,E1/E2/E3 Enzyme

2089293-61-6

C23H29Cl2N3O