SMER 3
- Product Name
- SMER 3
- CAS No.
- 67200-34-4
- Chemical Name
- SMER 3
- Synonyms
- SMER 3;SMER3(SMER 3);5-oxoinden[1,2-e]furazano[3,4-b]pyrazine;9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one;9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N;OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit
- CBNumber
- CB72565931
- Molecular Formula
- C11H4N4O2
- Formula Weight
- 224.18
- MOL File
- 67200-34-4.mol
SMER 3 Property
- Melting point:
- 283-284 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 437.2±55.0 °C(Predicted)
- Density
- 1.665±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥30mg/mL
- pka
- -8.15±0.20(Predicted)
- form
- powder
- color
- yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S7826
- Product name
- SMER3
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $113
- Updated
- 2024/03/01
- Product number
- S7826
- Product name
- SMER3
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 15324
- Product name
- SMER3
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 15324
- Product name
- SMER3
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $120
- Updated
- 2024/03/01
- Product number
- 15324
- Product name
- SMER3
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $199
- Updated
- 2024/03/01
SMER 3 Chemical Properties,Usage,Production
Description
SMER3 is a selective inhibitor of Skp1-
Uses
SMER3 is used in biological studies to evaluate the pharmacological activity as it is discovered as an inhibitor. SMER3 inhibits mTOR (mammalian target of rapamycin) which plays a key role in the growth control in eukaryotic cells. SMER is the small-molecule enhancer of rapamycin.
Definition
ChEBI: LSM-42773 is an aromatic ketone.
storage
Store at +4°C
References
1) Aghajanyy et al. (2010), Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor; Nat. Biotechnol., 28 738
SMER 3 Preparation Products And Raw materials
Raw materials
Preparation Products
SMER 3 Suppliers
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