SMER 3

Product Name: SMER 3
CAS No.: 67200-34-4
Chemical Name: SMER 3
Synonyms: SMER 3;SMER3(SMER 3);SMER3, 10 mM in DMSO;5-oxoinden[1,2-e]furazano[3,4-b]pyrazine;SMER3, SCFMet30 ubiquitin E3 ligase inhibitor;9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one;9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N;OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit
CBNumber: CB72565931
Molecular Formula: C11H4N4O2
Formula Weight: 224.18
MOL File: 67200-34-4.mol

More

Less

SMER 3 Property

Melting point:: 283-284 °C(Solv: ethanol (64-17-5))
Boiling point:: 437.2±55.0 °C(Predicted)
Density: 1.665±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥30mg/mL
pka: -8.15±0.20(Predicted)
form: powder
color: yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 1

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S7826
Product name: SMER3
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $98.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: S7826
Product name: SMER3
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $381
Updated: 2025/07/31

TCI Chemical

Product number: M3172
Product name: SMER3
Packaging: 10MG
Price: $113
Updated: 2025/07/31

TCI Chemical

Product number: M3172
Product name: SMER3
Packaging: 50MG
Price: $337
Updated: 2025/07/31

Cayman Chemical

Product number: 15324
Product name: SMER3
Purity: ≥95%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

More

Less

SMER 3 Chemical Properties,Usage,Production

Description

SMER3 is a selective inhibitor of Skp1-Cullin-F-box (SCF)^MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response. It is a small molecule enhancer of rapamycin , in that it enhances yeast cell lethality in response to rapamycin. SMER3, at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCF^MET30 complex, preventing ubiquitination of target proteins, including Met4. As ubiquitin E3 ligases are involved in tumorigenesis, SMER3 has potential applications in cancer research.

Uses

SMER3 is used in biological studies to evaluate the pharmacological activity as it is discovered as an inhibitor. SMER3 inhibits mTOR (mammalian target of rapamycin) which plays a key role in the growth control in eukaryotic cells. SMER is the small-molecule enhancer of rapamycin.

Definition

ChEBI: LSM-42773 is an aromatic ketone.

storage

Store at +4°C

References

[1] MARIAM AGHAJAN. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase[J]. Nature biotechnology, 2010, 28 7: 738-742. DOI:10.1038/nbt.1645

SMER 3 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

SMER 3 Suppliers

China 82 Europe 1 Japan 1 United Kingdom 1 United States 11 Global 96

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16075
Advantage: 64

Jinan Trio PharmaTech Co., Ltd.

Tel: 0531-88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com
Country: China
ProdList: 1856
Advantage: 62

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

TCI Europe

Tel: 320-37350700
Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
ProdList: 23671
Advantage: 75

SunaTech Inc.

Tel: 0512-62872180 18994314770
Fax: +86 512 62872181
Email: sales@sunatech.com
Country: China
ProdList: 1182
Advantage: 58

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Zhengzhou Huiju Chemical Co., Ltd.

Tel: 0371-55900031 18137872243
Fax: QQ：2853979815
Email: 2853979815@qq.com
Country: China
ProdList: 9996
Advantage: 55

JinJin Le Chemical Co., Ltd

Tel: 18001959627(微信同号) 18001959627
Email: jjlchem2@163.com
Country: China
ProdList: 9981
Advantage: 58

Shenzhen Regent Biochemical Technology Co., Ltd.

Tel: 0755-85201366 18938635012
Fax: 0755-85201366
Email: sales@regentsciences.com
Country: China
ProdList: 9751
Advantage: 58

67200-34-4, SMER 3Related Search:

P-5091 Pevonedistat MG-132 TOS-ARG-OME HCL

SMER 3

9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one

9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one

OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one

SMER3(SMER 3)

9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N

5-oxoinden[1,2-e]furazano[3,4-b]pyrazine

Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit

SMER3, SCFMet30 ubiquitin E3 ligase inhibitor

SMER3, 10 mM in DMSO

67200-34-4

C11H4N4O2