ChemicalBook > CAS DataBase List > SMER 3

SMER 3

Product Name
SMER 3
CAS No.
67200-34-4
Chemical Name
SMER 3
Synonyms
SMER 3;SMER3(SMER 3);5-oxoinden[1,2-e]furazano[3,4-b]pyrazine;9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one;9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N;OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit
CBNumber
CB72565931
Molecular Formula
C11H4N4O2
Formula Weight
224.18
MOL File
67200-34-4.mol
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SMER 3 Property

Melting point:
283-284 °C(Solv: ethanol (64-17-5))
Boiling point:
437.2±55.0 °C(Predicted)
Density 
1.665±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥30mg/mL
pka
-8.15±0.20(Predicted)
form 
powder
color 
yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S7826
Product name
SMER3
Purity
≥98% (HPLC)
Packaging
5mg
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
S7826
Product name
SMER3
Purity
≥98% (HPLC)
Packaging
25mg
Price
$436
Updated
2024/03/01
Cayman Chemical
Product number
15324
Product name
SMER3
Purity
≥95%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
15324
Product name
SMER3
Purity
≥95%
Packaging
10mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
15324
Product name
SMER3
Purity
≥95%
Packaging
25mg
Price
$199
Updated
2024/03/01
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SMER 3 Chemical Properties,Usage,Production

Description

SMER3 is a selective inhibitor of Skp1-Cullin-F-box (SCF)MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response. It is a small molecule enhancer of rapamycin , in that it enhances yeast cell lethality in response to rapamycin. SMER3, at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCFMET30 complex, preventing ubiquitination of target proteins, including Met4. As ubiquitin E3 ligases are involved in tumorigenesis, SMER3 has potential applications in cancer research.

Uses

SMER3 is used in biological studies to evaluate the pharmacological activity as it is discovered as an inhibitor. SMER3 inhibits mTOR (mammalian target of rapamycin) which plays a key role in the growth control in eukaryotic cells. SMER is the small-molecule enhancer of rapamycin.

Definition

ChEBI: LSM-42773 is an aromatic ketone.

storage

Store at +4°C

References

1) Aghajanyy et al. (2010), Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor; Nat. Biotechnol., 28 738

SMER 3 Preparation Products And Raw materials

Raw materials

Preparation Products

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SMER 3 Suppliers

Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19172
Advantage
64
Jinan Trio PharmaTech Co., Ltd.
Tel
+86 (531) 88811783
Fax
+86 (531) 55696010 QQ 1762738062
Email
sales@trio-pharmatech.com (International market)
Country
China
ProdList
1856
Advantage
62
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
TCI Europe
Tel
320-37350700
Fax
+32 (0)37350701
Email
sales@tcieurope.eu
Country
Europe
ProdList
23671
Advantage
75
SunaTech Inc.
Tel
0512-62872180 18994314770
Fax
+86 512 62872181
Email
sales@sunatech.com
Country
China
ProdList
1107
Advantage
58
Shanghai Xingui Biotechnology Co., Ltd.
Tel
17501653715
Email
xingui2022@126.com
Country
China
ProdList
10021
Advantage
58
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Zhengzhou Huiju Chemical Co., Ltd.
Tel
0371-55900031 18137872243
Fax
QQ:2853979815
Email
2853979815@qq.com
Country
China
ProdList
10011
Advantage
55
JinJin Le Chemical Co., Ltd
Tel
10106090
Email
jjlchem2@163.com
Country
China
ProdList
9981
Advantage
58

67200-34-4, SMER 3Related Search:


  • SMER 3
  • 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
  • 9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
  • OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
  • SMER3(SMER 3)
  • 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N
  • 5-oxoinden[1,2-e]furazano[3,4-b]pyrazine
  • Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit
  • 67200-34-4
  • C11H4N4O2