SMER 3

ChemicalBook > CAS DataBase List > SMER 3

Product Name: SMER 3
CAS No.: 67200-34-4
Chemical Name: SMER 3
Synonyms: SMER 3;SMER3(SMER 3);5-oxoinden[1,2-e]furazano[3,4-b]pyrazine;9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one;9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N;OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit
CBNumber: CB72565931
Molecular Formula: C11H4N4O2
Formula Weight: 224.18
MOL File: 67200-34-4.mol

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SMER 3 Property

Melting point:: 283-284 °C(Solv: ethanol (64-17-5))
Boiling point:: 437.2±55.0 °C(Predicted)
Density: 1.665±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥30mg/mL
pka: -8.15±0.20(Predicted)
form: powder
color: yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S7826
Product name: SMER3
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $113
Updated: 2024/03/01

Sigma-Aldrich

Product number: S7826
Product name: SMER3
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $436
Updated: 2024/03/01

Cayman Chemical

Product number: 15324
Product name: SMER3
Purity: ≥95%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 15324
Product name: SMER3
Purity: ≥95%
Packaging: 10mg
Price: $120
Updated: 2024/03/01

Cayman Chemical

Product number: 15324
Product name: SMER3
Purity: ≥95%
Packaging: 25mg
Price: $199
Updated: 2024/03/01

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SMER 3 Chemical Properties,Usage,Production

Description

SMER3 is a selective inhibitor of Skp1-Cullin-F-box (SCF)^MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response. It is a small molecule enhancer of rapamycin , in that it enhances yeast cell lethality in response to rapamycin. SMER3, at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCF^MET30 complex, preventing ubiquitination of target proteins, including Met4. As ubiquitin E3 ligases are involved in tumorigenesis, SMER3 has potential applications in cancer research.

Uses

SMER3 is used in biological studies to evaluate the pharmacological activity as it is discovered as an inhibitor. SMER3 inhibits mTOR (mammalian target of rapamycin) which plays a key role in the growth control in eukaryotic cells. SMER is the small-molecule enhancer of rapamycin.

Definition

ChEBI: LSM-42773 is an aromatic ketone.

storage

Store at +4°C

References

1) Aghajanyy et al. (2010), Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor; Nat. Biotechnol., 28 738

SMER 3 Preparation Products And Raw materials

Raw materials

Preparation Products

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SMER 3 Suppliers

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67200-34-4, SMER 3Related Search:

P-5091 Pevonedistat MG-132 TOS-ARG-OME HCL

SMER 3

9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one

9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one

OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one

SMER3(SMER 3)

9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N

5-oxoinden[1,2-e]furazano[3,4-b]pyrazine

Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit

67200-34-4

C11H4N4O2