PFM01

Product Name: PFM01
CAS No.: 1558598-41-6
Chemical Name: PFM01
Synonyms: PFM01;PFM01 ，S3549;PFM01 >=98% (HPLC);PFM01, 10 mM in DMSO;(Z)-5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxothiazolidin-4-one;(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone;4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-, (5Z)-;Inhibitor,derivative,MRE11,PFM-01,NHEJ,Mirin,DSB,endonuclease,N-alkylated,PFM01,PFM 01,inhibit
CBNumber: CB64670537
Molecular Formula: C14H15NO2S2
Formula Weight: 293.4
MOL File: 1558598-41-6.mol

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PFM01 Property

Boiling point:: 435.2±55.0 °C(Predicted)
Density: 1.35±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in DMSO
form: powder
pka: 8.59±0.30(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1735
Product name: PFM01
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $116.85
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1735
Product name: PFM01
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $333.9
Updated: 2025/07/31

Tocris

Product number: 6222
Product name: PFM01
Purity: ≥98%(HPLC)
Packaging: 10
Price: $75
Updated: 2021/12/16

Tocris

Product number: 6222
Product name: PFM01
Purity: ≥98%(HPLC)
Packaging: 50
Price: $315
Updated: 2021/12/16

TRC

Product number: P293993
Product name: PFM01
Packaging: 1mg
Price: $45
Updated: 2021/12/16

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PFM01 Chemical Properties,Usage,Production

Uses

PFM01, N-alkylated Mirin derivative, is a MRE11 endonuclease inhibitor. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR)[1][2].

Biochem/physiol Actions

PFM01 is a cell-permeable N-alkylated Mirin (Sigma Cat. No. 475954) derivative that selectively inhibits against MRE11 endo-, but not exo-, nuclease activity. PFM01 targets MRE11 at a site near the dimer interface, distinct from that occupied by Mirin and PFM39 to allow disruption of the ssDNA-binding groove and selective inhibition against MRE11 endo-, but not exo-, nuclease activity. While both endonuclease and exonuclease activities are required for MRE11-mediated homologous recombination (HR) repair, only FM01 (100 μM), but not the exonuclease inhibitors Mirin (500 μM) and PFM39 (100 μM), rescues G2-phase double-strand break (DSB) repair defect in HR protein BRCA2-deficient HSC62-hTERT fibroblasts following ionizing irradiation (IR) by blocking HR initiation and thereby allowing non-homologous end joining (NHEJ) to proceed.

storage

Store at -20°C

References

[1] Shibata A, et, al. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell. 2014 Jan 9; 53(1): 7-18. DOI:10.1016/j.molcel.2013.11.003
[2] V?lkening L, et, al. RAD50 regulates mitotic progression independent of DNA repair functions. FASEB J. 2020 Feb; 34(2): 2812-2820. DOI:10.1096/fj.201902318R

PFM01 Preparation Products And Raw materials

Raw materials

Preparation Products

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PFM01 Suppliers

China 34 United Kingdom 1 United States 8 USA 1 Global 44

Nanjing Dulai Biotechnology Co., Ltd.

Tel: 025-846993838003-8003 18013301590
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Country: China
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Sigma-Aldrich

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Email: orderCN@merckgroup.com
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Shanghai EFE Biological Technology Co., Ltd.

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Email: info@efebio.com
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Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
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Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
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Email: klq@cw-bio.com
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ShangHai Biochempartner Co.,Ltd

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Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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InvivoChem

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Labnetwork lnc.

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Email: contact@labnetwork.com
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1558598-41-6, PFM01Related Search:

PFM01

(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone

PFM01 >=98% (HPLC)

(Z)-5-(4-Hydroxybenzylidene)-3-isobutyl-2-thioxothiazolidin-4-one

Inhibitor,derivative,MRE11,PFM-01,NHEJ,Mirin,DSB,endonuclease,N-alkylated,PFM01,PFM 01,inhibit

4-Thiazolidinone, 5-[(4-hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-, (5Z)-

PFM01, 10 mM in DMSO

PFM01 ，S3549

1558598-41-6