Risdiplam

Product Name: Risdiplam
CAS No.: 1825352-65-5
Chemical Name: Risdiplam
Synonyms: RG7916;2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one;Lispran;RO7034067;Risdiplam;Risdiplam (RG7916);Risdiplam (RG7916) ，S6925;Risdiplam (RG-7916, RO-7034067);7-amino-2,3-dihydro-1H-inden-4-ol;RG 7916,Inhibitor,RG-7916,Risdiplam,RO 7034067,DNA/RNA Synthesis,RO-7034067,inhibit
CBNumber: CB64674494
Molecular Formula: C22H23N7O
Formula Weight: 401.46
MOL File: 1825352-65-5.mol

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Risdiplam Property

Density: 1.50±0.1 g/cm3(Predicted)
solubility: Soluble in DMSO
pka: 9.41±0.20(Predicted)
form: solid
color: Light yellow to yellow
InChI: InChI=1S/C22H23N7O/c1-14-9-18(26-29-11-15(2)24-21(14)29)17-10-20(30)28-12-16(3-4-19(28)25-17)27-8-7-23-22(13-27)5-6-22/h3-4,9-12,23H,5-8,13H2,1-2H3
InChIKey: ASKZRYGFUPSJPN-UHFFFAOYSA-N
SMILES: C12C=CC(N3CC4(CC4)NCC3)=CN1C(=O)C=C(C1=NN3C=C(C)N=C3C(C)=C1)N=2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29028
Product name: Risdiplam
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 29028
Product name: Risdiplam
Packaging: 25mg
Price: $353
Updated: 2024/03/01

Cayman Chemical

Product number: 29028
Product name: Risdiplam
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 29028
Product name: Risdiplam
Packaging: 10mg
Price: $213
Updated: 2024/03/01

ChemScene

Product number: CS-0039501
Product name: Risdiplam
Purity: 99.35%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

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Risdiplam Chemical Properties,Usage,Production

Description

Risdiplam is a survival of motor neuron 2 (SMN2) splicing modifier.

Chemical Properties

light yellow powder to yellow powder

Uses

Risdiplam is used in preparation of Imidazopyridazinyl Pyridopyrimidinones for treating spinal muscular atrophy. Gene splicing modulator.

Mechanism of action

Risdiplam works by modifying the splicing process of the SMN2 gene, increasing the production of full-length and functional SMN protein.

Side effects

Body aches or pain, chest pain or tightness, chills, cough, ear congestion, fever, headache, loss of voice, runny or stuffy nose, sneezing, sore throat, trouble breathing, unusual tiredness or weakness and so on.

Synthesis

SNAr reaction between amine 194 and bromopyridine 195 gave 196 in good yield. Reduction by hydrogenation in the presence of a platinum catalyst followed by treatment with di-tert-butyl malonate gave pyridopyrimidone 197 in benzoxazole at elevated temperature in good overall yield for both steps. Mesylation to form sulfonate 198 then participated in a Suzuki coupling with 200 (derived from aryl chloride 199 via Miyaura coupling) to establish the risdiplam core skeleton. N-Boc deprotection of 201 using hydrochloric acid in isopropanol gave risdiplam (XXVI) which was isolated after pH adjustment.

storage

0-4℃ for short term (days to weeks) or -20℃ for long term (months)

Risdiplam Preparation Products And Raw materials

Raw materials

Preparation Products

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Risdiplam Suppliers

China 156 United States 6 USA 1 Global 163

Hangzhou Kehui Pharmaceutical Co.,Ltd

Tel: 0571-87359773 18094707759
Email: sales10@hzkehuipharma.com
Country: China
ProdList: 49
Advantage: 58

Shanghai Changyu Medical Technology Co. Ltd.

Tel: +86-13301875428
Email: sales@changyuhe.com
Country: China
ProdList: 311
Advantage: 58

Jiangsu Magic Biotechnology Co., Ltd

Tel: 13921770081
Email: svp01@magicbiotech.cn
Country: China
ProdList: 500
Advantage: 58

Jilin Lianben Technology Development Co., Ltd

Tel: 0432-62601618 13756693631
Fax: 0432-62601618
Email: wangjiaqi@lianben.com
Country: China
ProdList: 46
Advantage: 58

Biopole Pharmatech Co., Ltd.

Tel: 0512-65974739-0 15151475053
Email: mengqi_biopole@163.com
Country: China
ProdList: 66
Advantage: 58

Zhengzhou Runkai Pharmaceutical Technology Co., Ltd

Tel: 191-19137044811 19137644811
Email: 3649307081@qq.com
Country: China
ProdList: 500
Advantage: 58

Linyi Shengyuan Biotechnology Co., LTD

Tel: 13953971485
Email: 2199605322@qq.com
Country: China
ProdList: 200
Advantage: 58

Yunnan Huapai Pharmaceutical Technology Co., Ltd.

Tel: 0886-1313565-2018 18662190408
Email: 275443226@qq.com
Country: China
ProdList: 148
Advantage: 58

Beijing Hope International Pharmaceutical Technology Development Co., Ltd

Tel: 010-67887110-8057 15600038801
Fax: 010-67887110-8016
Email: wuhangjin@hopelife.cn
Country: China
ProdList: 20
Advantage: 58

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

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View Lastest Price from Risdiplam manufacturers

Shaanxi Didu New Materials Co. Ltd

Product: Risdiplam 1825352-65-5
Price: US $1.50/g
Min. Order: 1g
Purity: 99.0% Min
Supply Ability: 1 kg
Release date: 2025-04-03

Hebei Yanxi Chemical Co., Ltd.

Product: Risdiplam 1825352-65-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-08

Apeloa production Co.,Limited

Product: Risdiplam 1825352-65-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000
Release date: 2024-06-05

1825352-65-5, RisdiplamRelated Search:

7-amino-2,3-dihydro-1H-inden-4-ol

Risdiplam

RO7034067

RG7916

4H-Pyrido[1,2-a]pyrimidin-4-one, 7-(4,7-diazaspiro[2.5]oct-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-

2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)-7-(4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

Risdiplam (RG-7916, RO-7034067)

RG 7916,Inhibitor,RG-7916,Risdiplam,RO 7034067,DNA/RNA Synthesis,RO-7034067,inhibit

2-(4,6-dimethylpyrrolo[1,2-b]pyridazin-2-yl)-7-(4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one

7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8-dimethylimidazo[1,2-b]pyridazin-6-yl)pyrido[1,2-a]pyrimidin-4-one

Risdiplam (RG7916)

Lispran

Risdiplam (RG7916) ，S6925

"7-(4,7-diazaspiro[2.5]octan-7-yl)-2-(2,8- dimethylimidazo[1,2-b]pyridazin-6-yl)-4H-pyrido[1,2-a]pyrimidin-4-one"

1825352-65-5

1825352-65-6

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