PF-05231023
- Product Name
- PF-05231023
- CAS No.
- 1037589-69-7
- Chemical Name
- PF-05231023
- Synonyms
- PF5231023;PF-5231023;PF 5231023;PF-05231023;mal-PEG2-AZD;Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD;Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD, 10 mM in DMSO;PF-05231023; PF05231023; PF 05231023; PF-5231023; PF5231023; PF 5231023;Mal-amido-PEG-2-C2-amido-Ph-C2-CO-AZD,PROTAC Linkers,MalamidoPEG2C2amidoPhC2COAZD,Inhibitor,Mal amido PEG2 C2 amido Ph C2 CO AZD,inhibit;1H-Pyrrole-1-propanamide, 2,5-dihydro-2,5-dioxo-N-[2-[2-[3-oxo-3-[[4-[3-oxo-3-(2-oxo-1-azetidinyl)propyl]phenyl]amino]propoxy]ethoxy]ethyl]-
- CBNumber
- CB64677804
- Molecular Formula
- C26H32N4O8
- Formula Weight
- 528.55
- MOL File
- 1037589-69-7.mol
PF-05231023 Property
- Boiling point:
- 849.9±65.0 °C(Predicted)
- Density
- 1.345±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml
- form
- A solid
- pka
- 14.34±0.70(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- orb573336
- Product name
- PF-05231023
- Purity
- >98%
- Packaging
- 100mg
- Price
- $912.9
- Updated
- 2021/12/16
- Product number
- orb573336
- Product name
- PF-05231023
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1802
- Updated
- 2021/12/16
- Product number
- orb573336
- Product name
- PF-05231023
- Purity
- >98%
- Packaging
- 1g
- Price
- $3580.2
- Updated
- 2021/12/16
- Product number
- DC20145
- Product name
- PF-05231023
- Purity
- >98%
- Packaging
- 100mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- DC20145
- Product name
- PF-05231023
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1200
- Updated
- 2021/12/16
PF-05231023 Chemical Properties,Usage,Production
Uses
Mal-amido-PEG2-C2-amido-Ph-C2-CO-AZD (Mal-PEG2-AZD) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
in vivo
| Animal Model: | Eight week old Zucker rats[3] |
| Dosage: | 3?mg/kg and 10?mg/kg |
| Administration: | Subcutaneously twice a week for two weeks |
| Result: | There was no change of BW observed, and food intake was not changed in the treated groups compared to control. Caused a significant decrease of glucose excursion during the oral glucose tolerance test (OGTT) compared to control. |
| Animal Model: | 7-to-8-month-old Akita mice with type 1 diabete model[4] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneally injected; twice a week; for four weeks |
| Result: | Administration improved retinal function in diabetic Akita mice. |
IC 50
PEGs
References
[1] Sonoda J, et al. FGF21-receptor agonists: an emerging therapeutic class for obesity-related diseases. Horm Mol Biol Clin Investig. 2017 May 19;30(2). DOI:10.1515/hmbci-2017-0002
PF-05231023 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-05231023 Suppliers
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