PF 05175157
- Product Name
- PF 05175157
- CAS No.
- 1301214-47-0
- Chemical Name
- PF 05175157
- Synonyms
- CS-2573;PF 05175157;PF 05175157;PF-05175157;PF-05175157 >=98% (HPLC);PF-05175157, 10 mM in DMSO; 1'-(2-methyl-3H-benzimidazole-5-carbonyl)-1-propan-2-ylspiro[4,6-dihydroindazole-5,4'-piperidine]-7-one;1-Isopropyl-1'-(2-methyl-1H-benzo[d]imidazole-6-carbonyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one;1-isopropyl-1'-(2-methyl-1H-benzo[d]imidazole-5-carbonyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one;1-Isopropyl-1'-(2-methyl-1H-benzo[d]imidazole-6-carbonyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one;ACC, Acetyl Coenzyme A Carboxylase,Acetyl-CoA Carboxylase,inhibit,Inhibitor,PF 05175157,PF-05175157,PF05175157
- CBNumber
- CB23164842
- Molecular Formula
- C23H27N5O2
- Formula Weight
- 405.49
- MOL File
- 1301214-47-0.mol
PF 05175157 Property
- Boiling point:
- 692.0±55.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:20.0(Max Conc. mg/mL);49.38(Max Conc. mM)
- form
- A crystalline solid
- pka
- 11.47±0.10(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21778
- Product name
- PF-05175157
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 21778
- Product name
- PF-05175157
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 21778
- Product name
- PF-05175157
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $176
- Updated
- 2024/03/01
- Product number
- 21778
- Product name
- PF-05175157
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $396
- Updated
- 2024/03/01
- Product number
- 5790
- Product name
- PF05175157
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $711
- Updated
- 2021/12/16
PF 05175157 Chemical Properties,Usage,Production
Uses
PF-05175157 has been used as an acetyl-Coenzyme A carboxylase (ACC) inhibitor to study its effects on the infection of flavivirus.
Biological Activity
PF-05175157 is a potent and selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 located primarily in liver and adipose tissue and isoform ACC2 dominant in skeletal and heart muscle, with IC50 values of 27 nM and 33 nM, respectively. Acetyl CoA carboxylase (ACC) generates malonyl CoA, which is a substrate for de novo lipogenesis and is also an inhibitor of mitochondrial fatty acid β-oxidation through inihbition of carnitine-palmitoyl transferase I (CPT-1), responsible for the transport of long-chain fatty acyl-CoAs across the mitochondrial membrane. ACC inihibitors are hoped to inhibit de novo lipogenesis and increase β-oxidation of long-chain fatty acids with potential for treatment of type 2 diabetes, hepatic steatosis, and cancer. In Phase I clinical studies for diabetes treatment, PF-05175157 inhibited de novo lipogenesis and increased net whole-body fatty acid utilization.
storage
Store at +4°C
PF 05175157 Preparation Products And Raw materials
Raw materials
Preparation Products
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