PF 05175157

Product Name: PF 05175157
CAS No.: 1301214-47-0
Chemical Name: PF 05175157
Synonyms: CS-2573;PF 05175157;PF 05175157;PF-05175157;PF-05175157 >=98% (HPLC);PF-05175157, 10 mM in DMSO; 1'-(2-methyl-3H-benzimidazole-5-carbonyl)-1-propan-2-ylspiro[4,6-dihydroindazole-5,4'-piperidine]-7-one;1-Isopropyl-1'-(2-methyl-1H-benzo[d]imidazole-6-carbonyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one;1-isopropyl-1'-(2-methyl-1H-benzo[d]imidazole-5-carbonyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one;ACC, Acetyl Coenzyme A Carboxylase,Acetyl-CoA Carboxylase,inhibit,Inhibitor,PF 05175157,PF-05175157,PF05175157;1,4-Dihydro-1'-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one
CBNumber: CB23164842
Molecular Formula: C23H27N5O2
Formula Weight: 405.49
MOL File: 1301214-47-0.mol

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PF 05175157 Property

Boiling point:: 692.0±55.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:20.0(Max Conc. mg/mL);49.38(Max Conc. mM)
form: A crystalline solid
pka: 11.47±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21778
Product name: PF-05175157
Purity: ≥98%
Packaging: 1mg
Price: $33
Updated: 2024/03/01

Cayman Chemical

Product number: 21778
Product name: PF-05175157
Purity: ≥98%
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 21778
Product name: PF-05175157
Purity: ≥98%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 21778
Product name: PF-05175157
Purity: ≥98%
Packaging: 25mg
Price: $396
Updated: 2024/03/01

Tocris

Product number: 5790
Product name: PF05175157
Purity: ≥98%(HPLC)
Packaging: 50
Price: $711
Updated: 2021/12/16

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PF 05175157 Chemical Properties,Usage,Production

Uses

PF-05175157 has been used as an acetyl-Coenzyme A carboxylase (ACC) inhibitor to study its effects on the infection of flavivirus.

Biological Activity

PF-05175157 is a potent and selective inhibitor of both acetyl-CoA carboxylase isoform ACC1 located primarily in liver and adipose tissue and isoform ACC2 dominant in skeletal and heart muscle, with IC50 values of 27 nM and 33 nM, respectively. Acetyl CoA carboxylase (ACC) generates malonyl CoA, which is a substrate for de novo lipogenesis and is also an inhibitor of mitochondrial fatty acid β-oxidation through inihbition of carnitine-palmitoyl transferase I (CPT-1), responsible for the transport of long-chain fatty acyl-CoAs across the mitochondrial membrane. ACC inihibitors are hoped to inhibit de novo lipogenesis and increase β-oxidation of long-chain fatty acids with potential for treatment of type 2 diabetes, hepatic steatosis, and cancer. In Phase I clinical studies for diabetes treatment, PF-05175157 inhibited de novo lipogenesis and increased net whole-body fatty acid utilization.

storage

Store at +4°C

PF 05175157 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF 05175157 Suppliers

China 65 United Kingdom 1 United States 8 Global 74

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
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MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
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Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4674
Advantage: 55

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
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Shanghai Xingui Biotechnology Co., Ltd.

Tel: 17501653713
Email: xingui2022@126.com
Country: China
ProdList: 10009
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
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Shanghaizehan biopharma technology co., Ltd.

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Fax: 021-61350662
Email: sales@zehanbiopharma.com
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Xishi Chemical (Shanghai) Co., Ltd.

Tel: 021-60499358 13661956116
Fax: +86 (21) 5106-9359
Email: info@cs-pharm.com
Country: China
ProdList: 205
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Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6464
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Hui Chem Co., Ltd.

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Fax: 021-61916468
Email: 1879902218@qq.com
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1301214-47-0, PF 05175157Related Search:

PF-05231023 PF-04691502 PF-4634817 PF-06700841-TsOH PF-06700841 tosylate PF-06282999 PF 4618433 PF-06650833 PF-6260933 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- PF-01247324 PF 04995274 PNU 100480 PF-06281355 PF06869206

1-isopropyl-1'-(2-methyl-1H-benzo[d]imidazole-5-carbonyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one

1,4-Dihydro-1'-[2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-spiro[5H-indazole-5,4'-piperidin]-7(6H)-one

CS-2573

PF 05175157;PF-05175157

PF 05175157

Spiro[5H-indazole-5,4'-piperidin]-7(6H)-one,1,4-dihydro-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)-

PF-05175157 >=98% (HPLC)

1'-(2-methyl-1H-1,3-benzodiazole-6-carbonyl)-1-(pr opan-2-yl)-1,4,6,7-tetrahydrospiro[indazole-5,4'-pi peridin]-7-one

1'-(2-methyl-3H-benzimidazole-5-carbonyl)-1-propan-2-ylspiro[4,6-dihydroindazole-5,4'-piperidine]-7-one

1-Isopropyl-1'-(2-methyl-1H-benzo[d]imidazole-6-carbonyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one

ACC, Acetyl Coenzyme A Carboxylase,Acetyl-CoA Carboxylase,inhibit,Inhibitor,PF 05175157,PF-05175157,PF05175157

1-Isopropyl-1'-(2-methyl-1H-benzo[d]imidazole-6-carbonyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7(1H)-one , PF-05175157

(3-Methyl-5-isopropylphenyl)-N-methylcarbamat [German] | 1'-(2-methyl-3H-benzimidazole-5-carbonyl)-1-propan-2-ylspiro[4,6-dihydroindazole-5,4'-piperidine]-7-one | 1-Isopropyl-1'-(2-methyl-1H-benzo[d]i

PF-05175157, 10 mM in DMSO

1301214-47-0

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