PF-06282999

Product Name: PF-06282999
CAS No.: 1435467-37-0
Chemical Name: PF-06282999
Synonyms: CS-2543;PF-06282999;PF-06282999 (Free base);PF-06282999 >=98% (HPLC);PF-06282999, 10 mM in DMSO;PF-06282999;PF 06282999;PF06282999;PF06282999,Glutathione Peroxidase,PF 06282999,PF-06282999,Inhibitor,inhibit;1(2H)-Pyrimidineacetamide, 6-(5-chloro-2-methoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-;2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide
CBNumber: CB93145903
Molecular Formula: C13H12ClN3O3S
Formula Weight: 325.77
MOL File: 1435467-37-0.mol

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PF-06282999 Property

Density: 1.52±0.1 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO:30.0(Max Conc. mg/mL);92.1(Max Conc. mM)
form: powder
pka: 6.85±0.40(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0375
Product name: PF-06282999
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $102
Updated: 2024/03/01

Cayman Chemical

Product number: 28406
Product name: PF-06282999
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 28406
Product name: PF-06282999
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 28406
Product name: PF-06282999
Packaging: 10mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 28406
Product name: PF-06282999
Packaging: 25mg
Price: $374
Updated: 2024/03/01

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PF-06282999 Chemical Properties,Usage,Production

Biological Activity

PF-06282999 is an orally active thiouracil class myeloperoxidase (MPO) suicide substrate (kinact/KI = 11600 M-1s-1) th at targets MPO heme group for mechanism-based irreversible inactivation wtih high selectivity over thyroid peroxidase (TPO kinact/KI <3 M-1s-1) and heme-containing cytochrome P450 (CYP) isoforms (IC50 >100 μM). PF-06282999 effectively inhibits MPO activity in human blood stimulated by LPS ex vivo (IC50 = 1.9 μM) and in blood of LPS-treated cynomolgus monkeys in vivo (5-80 mg/kg p.o. 1hr post LPS i.v.) with good pharmacokinetics and oral availability (100%/86%/75%/76% in mice/rats/dogs/monkeys). PF-06282999 also exhibits weak PXR activating activity (EC50/Emax = 279 μM/9.36-fold vs.0.8 μM/19.6-fold with rifampin).

PF-06282999 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06282999 Suppliers

China 40 United States 8 Global 48

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4573
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9806
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27313
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 5944
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7312
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: lucy@atkchemical.com
Country: China
ProdList: 9987
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29764
Advantage: 68

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View Lastest Price from PF-06282999 manufacturers

Career Henan Chemical Co

Product: PF-06282999 1435467-37-0
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20kg
Release date: 2019-12-23

1435467-37-0, PF-06282999Related Search:

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PF-06282999

PF-06282999 (Free base)

2-(6-(5-chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide

CS-2543

PF-06282999;PF 06282999;PF06282999

1(2H)-Pyrimidineacetamide, 6-(5-chloro-2-methoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-

PF-06282999 >=98% (HPLC)

PF06282999,Glutathione Peroxidase,PF 06282999,PF-06282999,Inhibitor,inhibit

PF-06282999, 10 mM in DMSO

1435467-37-0