ChemicalBook > CAS DataBase List > PF-06650833

PF-06650833

Product Name
PF-06650833
CAS No.
1817626-54-2
Chemical Name
PF-06650833
Synonyms
CS-2457;PF06650883;PF-06650833;PF-05313261;PF-05320905;PF-05387282;Zimlovisertib;PF06650833;PF 06650833;PF06650833 >=98% (HPLC);Piraxostat Impurity 16
CBNumber
CB63147067
Molecular Formula
C18H20FN3O4
Formula Weight
361.37
MOL File
1817626-54-2.mol
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PF-06650833 Property

Boiling point:
621.0±55.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO : ≥ 33 mg/mL (91.32 mM)
form 
powder
pka
13.44±0.70(Predicted)
color 
white to beige
InChIKey
JKDGKIBAOAFRPJ-ZBINZKHDSA-N
SMILES
C1(OC[C@@H]2[C@H](CC)[C@H](F)C(=O)N2)C2=C(C=C(C(N)=O)C(OC)=C2)C=CN=1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0327
Product name
PF06650833
Purity
≥98% (HPLC)
Packaging
5mg
Price
$111
Updated
2025/07/31
Cayman Chemical
Product number
28397
Product name
PF-06650833
Packaging
5mg
Price
$69
Updated
2021/12/16
Cayman Chemical
Product number
28397
Product name
PF-06650833
Packaging
50mg
Price
$449
Updated
2021/12/16
Cayman Chemical
Product number
28397
Product name
PF-06650833
Packaging
25mg
Price
$259
Updated
2021/12/16
Cayman Chemical
Product number
28397
Product name
PF-06650833
Packaging
10mg
Price
$124
Updated
2021/12/16
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PF-06650833 Chemical Properties,Usage,Production

Uses

Zimlovisertib (PF-06650833) is a potent, selective and orally active inhibitor of interleukin-1 receptor associated kinase 4 (IRAK4) with IC50s of 0.2 and 2.4 nM in the cell and PBMC assay, respectively. Zimlovisertib is used to treat diseases such as rheumatoid arthritis, lupus, and lymphomas[1][2].

Biochem/physiol Actions

PF06650833 has been studied for its use in the treatment of Waldenstrom macroglobulinemia, indicated by overproduction of IgM (immunoglobulin M)-producing lymphoplasmacytic cells.

in vivo

Zimlovisertib (0.3-30 mg/kg; oral administration; for 2.5 hours; male Sprague-Dawley rats) treatment significantly inhibits LPS-induced TNF-α in a dose dependent manner. Mean exposures of Zimlovisertib in plasma are 2.1 nM, 7.7 nM, 19 nM and 150 nM free, respectively, at 2.5 hours after oral administration of Zimlovisertib at 0.3, 1, 3, and 30 mg/kg. The fraction unbound in rat plasma of Zimlovisertib is 0.3[1].

Animal Model:Male Sprague-Dawley rats[1]
Dosage:0.1 mg/kg, 1 mg/kg, 3 mg/kg, 30 mg/kg
Administration:Oral administration; for 2.5 hours
Result:Significantly inhibited LPS-induced TNF-α in a dose dependent manner.

IC 50

IRAK4: .2 nM (IC50)

storage

Store at -20°C

References

[1] Lee KL, et al. Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem. 2017 Jul 13;60(13):5521-5542. DOI:10.1021/acs.jmedchem.7b00231
[2] Seganish WM. Inhibitors of interleukin-1 receptor-associated kinase 4 (IRAK4): a patent review (2012-2015). Expert Opin Ther Pat. 2016 Aug;26(8):917-32. DOI:10.1080/13543776.2016.1202926

PF-06650833 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06650833 Suppliers

China 97 United Kingdom 1 United States 7 Global 105
Dezhou LonWel Pharmaceutical Technology Co., Ltd.
Tel
13761310616
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QQ: 39324283
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39324283@qq.com
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China
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Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
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China
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9510
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58
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
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4861
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58
Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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51395
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
Fax
+86-21-52996696
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China
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4757
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Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
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QQ:3008007432
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3008007409@qq.com
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China
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71826
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ShangHai Biochempartner Co.,Ltd
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177-54423994 17754423994
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QQ:2853530913
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2853530910@QQ.com
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China
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd
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028-83379370 13880556291
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028-87747383
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tcy@tcypharm.com
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China
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7218
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58
Jinan elephant international trading co., LTD
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Fax
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13006575422@163.com
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China
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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21-5161 9052
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Sales@ATKchemical.com
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China
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1817626-54-2, PF-06650833Related Search:

PNU 100480 PF 05175157 PF-06282999 PF 4618433 PF-6260933 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- PF-01247324 PF 477736 PF-06447475 Lorlatinib (PF-06463922) PF-06700841-TsOH PF-05212384 [(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinyl-methanone methanesulfonate PF-04691502 PF-5190457 PF-06882961 PF 573228 Ritlecitinib

  • PF-06650833
  • 1-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide
  • 6-Isoquinolinecarboxamide,1-(((2S,3S,4S)-3-ethyl-4-fluoro-5-oxo-2-pyrrolidinyl)methoxy)-7-methoxy-
  • PF06650833;PF 06650833
  • CS-2457
  • 1-[[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-6-isoquinolinecarboxamide
  • PF06650833 >=98% (HPLC)
  • PF06650883
  • Zimlovisertib
  • 1-[[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxyisoquinoline-6-carboxamide
  • Piraxostat Impurity 16
  • Zimlovisertib, 10 mM in DMSO
  • PF-05313261
  • PF-05320905
  • PF-05387282
  • Zimlovisertib (PF-06650833)
  • 1817626-54-2
  • API