ChemicalBook > CAS DataBase List > 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-

5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-

Product Name
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
CAS No.
1332708-14-1
Chemical Name
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
Synonyms
CS-2357;N-benzyl-4-[(2-methylpropyl)amino]-2-{4-[(oxan-3-yl)methyl]piperazin-1-yl}pyrimidine-5-carboxamide;N-benzyl-4-(isobutylamino)-2-(4-((tetrahydro-2H-pyran-3-yl)methyl)piperazin-1-yl)pyrimidine-5-carboxamide;4-[(2-Methylpropyl)amino]-N-(phenylmethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)methyl]-1-piperazinyl]-5-pyrimidinecarboxamide;5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-;PF 4840154,PF-4840154,licking,nocifensive,Inhibitor,non-electrophilic,PF4840154,inhibit,Transient receptor potential channels,behavior,TRP Channel
CBNumber
CB52702880
Molecular Formula
C26H38N6O2
Formula Weight
466.62
MOL File
1332708-14-1.mol
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5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Property

Density 
1.164±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
form 
A crystalline solid
pka
13.71±0.46(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28915
Product name
PF-4840154
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28915
Product name
PF-4840154
Packaging
25mg
Price
$533
Updated
2024/03/01
Cayman Chemical
Product number
28915
Product name
PF-4840154
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
28915
Product name
PF-4840154
Packaging
10mg
Price
$243
Updated
2024/03/01
ChemScene
Product number
CS-5066
Product name
PF-4840154
Purity
99.59%
Packaging
10mg
Price
$600
Updated
2021/12/16
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5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Chemical Properties,Usage,Production

Biological Activity

PF-4840154 is a potent and selective rat and human TrpA1 channel agonist with EC50 of 97 and 23 nM, respectively. PF-4840154 induces TrpA1-mediated nociceptive behavior in mice.

in vivo

PF-4840154 (30 nmol; intraplantar) elicits TrpA1-mediated nocifensive behaviour in mouse.

Animal Model: Female CD1 mice (25-30g) (In TrpA1+/+ mice)
Dosage: 30 nmol
Administration: Intraplantar (i.pl) injection
Result: Elicited robust licking behavior.

target

IC50: 97 nM (rTrpA1), 23 nM (hTrpA1)

5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Suppliers

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1332708-14-1, 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-Related Search:

PF-06700841-TsOH PF-06700841 tosylate PF-06282999 PF 4618433 PF-06650833 PF-6260933 PF-01247324 PF 04995274 PNU 100480 PF 05175157 PF-06281355 PF06869206

  • 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
  • N-benzyl-4-(isobutylamino)-2-(4-((tetrahydro-2H-pyran-3-yl)methyl)piperazin-1-yl)pyrimidine-5-carboxamide
  • CS-2357
  • 4-[(2-Methylpropyl)amino]-N-(phenylmethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)methyl]-1-piperazinyl]-5-pyrimidinecarboxamide
  • PF 4840154,PF-4840154,licking,nocifensive,Inhibitor,non-electrophilic,PF4840154,inhibit,Transient receptor potential channels,behavior,TRP Channel
  • N-benzyl-4-[(2-methylpropyl)amino]-2-{4-[(oxan-3-yl)methyl]piperazin-1-yl}pyrimidine-5-carboxamide
  • 1332708-14-1
  • C26H38N6O2