ChemicalBook > CAS DataBase List > 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
- Product Name
- 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
- CAS No.
- 1332708-14-1
- Chemical Name
- 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-
- Synonyms
- CS-2357;PF-4840154, 10 mM in DMSO;N-benzyl-4-[(2-methylpropyl)amino]-2-{4-[(oxan-3-yl)methyl]piperazin-1-yl}pyrimidine-5-carboxamide;N-benzyl-4-(isobutylamino)-2-(4-((tetrahydro-2H-pyran-3-yl)methyl)piperazin-1-yl)pyrimidine-5-carboxamide;4-[(2-Methylpropyl)amino]-N-(phenylmethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)methyl]-1-piperazinyl]-5-pyrimidinecarboxamide;5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-;PF 4840154,PF-4840154,licking,nocifensive,Inhibitor,non-electrophilic,PF4840154,inhibit,Transient receptor potential channels,behavior,TRP Channel
- CBNumber
- CB52702880
- Molecular Formula
- C26H38N6O2
- Formula Weight
- 466.62
- MOL File
- 1332708-14-1.mol
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5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Property
- Density
- 1.164±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.1 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml
- form
- A crystalline solid
- pka
- 13.71±0.46(Predicted)
- color
- White to off-white
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 28915
- Product name
- PF-4840154
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 28915
- Product name
- PF-4840154
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 28915
- Product name
- PF-4840154
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 28915
- Product name
- PF-4840154
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
ChemScene
- Product number
- CS-5066
- Product name
- PF-4840154
- Purity
- 99.59%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
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5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Chemical Properties,Usage,Production
Uses
PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse[1].
Biological Activity
PF-4840154 is a potent and selective rat and human TrpA1 channel agonist with EC50 of 97 and 23 nM, respectively. PF-4840154 induces TrpA1-mediated nociceptive behavior in mice.
in vivo
PF-4840154 (30 nmol; intraplantar) elicits TrpA1-mediated nocifensive behaviour in mouse.
| Animal Model: | Female CD1 mice (25-30g) (In TrpA1+/+ mice) |
| Dosage: | 30 nmol |
| Administration: | Intraplantar (i.pl) injection |
| Result: | Elicited robust licking behavior. |
target
IC50: 97 nM (rTrpA1), 23 nM (hTrpA1)
References
[1] Ryckmans T, et al. Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4857-4859. DOI:10.1016/j.bmcl.2011.06.035
5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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1332708-14-1, 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]-Related Search:
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