ChemicalBook > CAS DataBase List > PF-06700841-TsOH

PF-06700841-TsOH

Product Name
PF-06700841-TsOH
CAS No.
2140301-96-6
Chemical Name
PF-06700841-TsOH
Synonyms
CS-2860;PF 06700841-15;PF-06700841-TsOH;PF-06700841 free base;Brepocitinib tosylate;PF-06700841 P-TOSYLATE;Brepocitinib (P-Tosylate);Brepocitinib P-Tosylate, 10 mM in DMSO;Janus kinase,JAK,Brepocitinib P-Tosylate,inhibit,Brepocitinib PTosylate,Inhibitor,Brepocitinib P Tosylate;((S)-2,2-Difluorocyclopropyl)(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone 4-methylbenzenesulfonate
CBNumber
CB94675331
Molecular Formula
C25H29F2N7O4S
Formula Weight
561.61
MOL File
2140301-96-6.mol
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PF-06700841-TsOH Property

storage temp. 
Store at -20°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:20): 50μg/ml; Ethanol: slightly soluble
form 
A crystalline solid
color 
White to off-white
InChIKey
FAKGOYNHHHOTEN-QYGWXNHUNA-N
SMILES
S(C1C=CC(C)=CC=1)(O)(=O)=O.C([C@@H]1CC1(F)F)(N1C2CCC1CN(C1C=CN=C(NC3=CN(C)N=C3)N=1)C2)=O |&1:12,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
26125
Product name
PF-06700841 (tosylate)
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
26125
Product name
PF-06700841 (tosylate)
Packaging
10mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
26125
Product name
PF-06700841 (tosylate)
Purity
≥98%
Packaging
25mg
Price
$343
Updated
2024/03/01
Cayman Chemical
Product number
26125
Product name
PF-06700841 (tosylate)
Packaging
5mg
Price
$100
Updated
2024/03/01
ChemScene
Product number
CS-0066286
Product name
PF-06700841(P-Tosylate)
Purity
99.66%
Packaging
10mg
Price
$140
Updated
2021/12/16
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PF-06700841-TsOH Chemical Properties,Usage,Production

Uses

Brepocitinib (PF-06700841) P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Brepocitinib P-Tosylate also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively[1].

in vivo

Brepocitinib (Compound 23; 3-30 mg/kg; oral administration; for 7 consecutive days; female Lewis rats) treatment significantly reduces paw volume increase in a dose-dependent manner. The plasma concentrations in animals dosed with Brepocitinib at peak (30 min) and trough (24 h) time intervals post final dose respectively are as follows: 3 mg/kg, 3.54 μM, 0.0221 μM; 10 mg/kg, 10.95 μM, 0.06 μM; and 30 mg/kg, 23.89 μM, 0.06 μM[1].

Animal Model:Female Lewis rats with induced arthritis[1]
Dosage:3 mg/kg, 10 mg/kg, or 30 mg/kg
Administration:Oral administration; for 7 consecutive days
Result:Increased in paw volume was significantly lower and dose-dependent.

IC 50

JAK1: 17 nM (IC50); JAK2: 77 nM (IC50); JAK3: 6.9 μM (IC50)

References

[1] Fensome A, et al. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700 DOI:10.1021/acs.jmedchem.8b00917

PF-06700841-TsOH Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06700841-TsOH Suppliers

China 56 United States 5 Global 61
Fujian boshi pharmaceutical technology co. LTD
Tel
0595-22008920; 18120708884
Email
393612455@qq.com
Country
China
ProdList
255
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58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
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64
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
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55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
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62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
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9126
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58
Twochem Co.Ltd.
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021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
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1788
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58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
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9729
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58
Taizhou Crene Biotechnology Co. Ltd.
Tel
+86-0576-88813233 +86-13396860566
Email
sales@pharm-intermediates.com
Country
China
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1991
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58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
ProdList
1886
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58
Jinan Carbotang Biotech Co.,Ltd.
Tel
+8615866703830
Email
figo.gao@foxmail.com
Country
China
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8497
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2140301-96-6, PF-06700841-TsOHRelated Search:

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  • PF-06700841-TsOH
  • PF-06700841 free base
  • CS-2860
  • PF-06700841 P-TOSYLATE
  • Brepocitinib tosylate
  • Brepocitinib (P-Tosylate)
  • Janus kinase,JAK,Brepocitinib P-Tosylate,inhibit,Brepocitinib PTosylate,Inhibitor,Brepocitinib P Tosylate
  • PF 06700841-15
  • ((S)-2,2-Difluorocyclopropyl)(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone 4-methylbenzenesulfonate
  • Brepocitinib P-Tosylate, 10 mM in DMSO
  • 2140301-96-6
  • API