ChemicalBook > CAS DataBase List > PF-06700841-TsOH

PF-06700841-TsOH

Product Name: PF-06700841-TsOH
CAS No.: 2140301-96-6
Chemical Name: PF-06700841-TsOH
Synonyms: CS-2860;PF 06700841-15;PF-06700841-TsOH;PF-06700841 free base;Brepocitinib tosylate;PF-06700841 P-TOSYLATE;Brepocitinib (P-Tosylate);Brepocitinib P-Tosylate, 10 mM in DMSO;Janus kinase,JAK,Brepocitinib P-Tosylate,inhibit,Brepocitinib PTosylate,Inhibitor,Brepocitinib P Tosylate;((S)-2,2-Difluorocyclopropyl)(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone 4-methylbenzenesulfonate
CBNumber: CB94675331
Molecular Formula: C25H29F2N7O4S
Formula Weight: 561.61
MOL File: 2140301-96-6.mol

Less

PF-06700841-TsOH Property

storage temp.: Store at -20°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:20): 50μg/ml; Ethanol: slightly soluble
form: A crystalline solid
color: White to off-white
InChIKey: FAKGOYNHHHOTEN-QYGWXNHUNA-N
SMILES: S(C1C=CC(C)=CC=1)(O)(=O)=O.C([C@@H]1CC1(F)F)(N1C2CCC1CN(C1C=CN=C(NC3=CN(C)N=C3)N=1)C2)=O |&1:12,r|

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 26125
Product name: PF-06700841 (tosylate)
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 26125
Product name: PF-06700841 (tosylate)
Packaging: 10mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 26125
Product name: PF-06700841 (tosylate)
Purity: ≥98%
Packaging: 25mg
Price: $343
Updated: 2024/03/01

Cayman Chemical

Product number: 26125
Product name: PF-06700841 (tosylate)
Packaging: 5mg
Price: $100
Updated: 2024/03/01

ChemScene

Product number: CS-0066286
Product name: PF-06700841(P-Tosylate)
Purity: 99.66%
Packaging: 10mg
Price: $140
Updated: 2021/12/16

Less

PF-06700841-TsOH Chemical Properties,Usage,Production

Uses

Brepocitinib (PF-06700841) P-Tosylate is a potent dual Janus kinase 1 (JAK1) and TYK2 inhibitor with IC50s of 17 nM and 23 nM, respectively. Brepocitinib P-Tosylate also inhibits JAK2 and JAK3 with IC50s of 77 nM and 6.49 μM, respectively[1].

in vivo

Brepocitinib (Compound 23; 3-30 mg/kg; oral administration; for 7 consecutive days; female Lewis rats) treatment significantly reduces paw volume increase in a dose-dependent manner. The plasma concentrations in animals dosed with Brepocitinib at peak (30 min) and trough (24 h) time intervals post final dose respectively are as follows: 3 mg/kg, 3.54 μM, 0.0221 μM; 10 mg/kg, 10.95 μM, 0.06 μM; and 30 mg/kg, 23.89 μM, 0.06 μM^[1].

Animal Model:	Female Lewis rats with induced arthritis^[1]
Dosage:	3 mg/kg, 10 mg/kg, or 30 mg/kg
Administration:	Oral administration; for 7 consecutive days
Result:	Increased in paw volume was significantly lower and dose-dependent.

IC 50

JAK1: 17 nM (IC₅₀); JAK2: 77 nM (IC₅₀); JAK3: 6.9 μM (IC₅₀)

References

[1] Fensome A, et al. Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700 DOI:10.1021/acs.jmedchem.8b00917

PF-06700841-TsOH Preparation Products And Raw materials

Raw materials

Preparation Products

Less

PF-06700841-TsOH Suppliers

China 56 United States 5 Global 61

Fujian boshi pharmaceutical technology co. LTD

Tel: 0595-22008920; 18120708884
Email: 393612455@qq.com
Country: China
ProdList: 255
Advantage: 58

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1077
Advantage: 64

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4769
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
Advantage: 58

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1991
Advantage: 58

Tianjin Kaifu Pharmaceutical Technology Co., Ltd.

Tel: 18081075745
Email: chemflowtech@sina.com
Country: China
ProdList: 1886
Advantage: 58

Jinan Carbotang Biotech Co.,Ltd.

Tel: +8615866703830
Email: figo.gao@foxmail.com
Country: China
ProdList: 8497
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5167
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Shanghai hongqu biomedical technology co. LTD

Tel: 88888888888
Email: hongquchem@qq.com
Country: China
ProdList: 5132
Advantage: 58

Shanghai Luofa Biochemical Technology Co., Ltd.

Tel: 021-51111890 15317326293
Email: sales@molnova.com
Country: China
ProdList: 4195
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 4989
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9814
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7986
Advantage: 58

Abmole Bioscience Inc.

Tel: 021-50967598 02150967598
Email: sales@abmole.cn
Country: China
ProdList: 4494
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Email: 2853979819@qq.com
Country: China
ProdList: 9998
Advantage: 58

Zhengzhou Akem Chemical Co., Ltd

Tel: 13303867194
Email: 3001317055@qq.com
Country: China
ProdList: 9681
Advantage: 58

Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 2998
Advantage: 58

Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd.

Tel: 15720605021
Fax: QQ：353175721
Email: zhang_lei@jsnchem.com
Country: China
ProdList: 1810
Advantage: 58

Hubei Kele Fine Chemical Co., Ltd

Tel: 027-59101668 19945030958
Fax: 027-59101668
Email: 2881924765@qq.com
Country: China
ProdList: 7938
Advantage: 58

Hubei wei shi reagent group ltd., company

Tel: 027-59102966 18717199209
Fax: 027-59379337
Email: 2853877583@qq.com
Country: China
ProdList: 2715
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

Wuhan Yingnuo Pharmaceutical Technology Co., Ltd.

Tel: 15387063101
Email: 2881924050@qq.com
Country: China
ProdList: 9960
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 4310
Advantage: 58

Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 5929
Advantage: 58

Suzhou Haiben Pharmaceutical Co., Ltd

Tel: 19353112242
Email: 1816280386@qq.com
Country: China
ProdList: 8045
Advantage: 58

PharmaBlock Sciences (Nanjing), Inc.

Tel: 4000255188
Email: sales@pharmablock.com
Country: China
ProdList: 7268
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 5002
Advantage: 58

Suzhou Meidi Senuo Pharmaceutical Technology Co., Ltd.

Tel: 13771642864
Fax: 1078336263
Email: snhuyu_2008@126.com
Country: China
ProdList: 1165
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai jerryxing Biomedical Technology Co., Ltd

Tel: 17721492509; 17721492509
Email: 643638326@qq.com
Country: China
ProdList: 4970
Advantage: 58

Changsha Fuzhen Biotechnology Co.，LTD

Tel: 0731-13823398 15111215862
Email: 313359644@qq.com
Country: China
ProdList: 4161
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: hanfangpharma@126.com; 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29965
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Olix (Shanghai) Pharmaceutical Technology Co., Ltd

Tel: 17316404525 17316404525
Email: 209533805@qq.com
Country: China
ProdList: 9766
Advantage: 58

Elucigen bio

Tel: 13501719342; 13501719342
Email: wayne.zheng@elucigenbio.com
Country: China
ProdList: 5000
Advantage: 58

Tanmo Quality Inspection Technology Co., Ltd.

Tel: 4008-099-669
Email: 23419001name@qq.com
Country: CHINA
ProdList: 6043
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Adooq Bioscience LLC

Tel: 400-025-6535
Email: sales@adooq.cn
Country: China
ProdList: 6215
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

Suzhou ARTK Medchem Co., Ltd.

Tel: +86-512-68323658 +86-18168183658
Email: sales1@artkmedchem.com
Country: China
ProdList: 39002
Advantage: 58

Kunming Shengyuan Technology Co., Ltd

Tel: 18987584767
Country: CHINA
ProdList: 165
Advantage: 58

2140301-96-6, PF-06700841-TsOHRelated Search:

PNU 100480 PF 05175157 PF-06282999 PF 4618433 PF-06650833 PF-6260933 5-PyriMidinecarboxaMide, 4-[(2-Methylpropyl)aMino]-N-(phenylMethyl)-2-[4-[(tetrahydro-2H-pyran-3-yl)Methyl]-1-piperazinyl]- PF-01247324 PF-05212384 PF-562271 Ketohexokinase inhibitor 1 PF-6274484 PF-9366 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione PF-3758309 PF-04979064 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid

PF-06700841-TsOH

PF-06700841 free base

CS-2860

PF-06700841 P-TOSYLATE

Brepocitinib tosylate

Brepocitinib (P-Tosylate)

Janus kinase,JAK,Brepocitinib P-Tosylate,inhibit,Brepocitinib PTosylate,Inhibitor,Brepocitinib P Tosylate

PF 06700841-15

((S)-2,2-Difluorocyclopropyl)(3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone 4-methylbenzenesulfonate

Brepocitinib P-Tosylate, 10 mM in DMSO

2140301-96-6

API