PF-6260933

Product Name: PF-6260933
CAS No.: 1811510-56-1
Chemical Name: PF-6260933
Synonyms: PF06260933;PF-6260933;5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine;[3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-;PF 06260933;PF06260933;PF6260933;PF 6260933;PF-6260933;inhibit,MAP4K,MAPK Kinase Kinase Kinase,PF 06260933,PF06260933,Inhibitor,PF-06260933
CBNumber: CB53344890
Molecular Formula: C16H13ClN4
Formula Weight: 296.75
MOL File: 1811510-56-1.mol

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PF-6260933 Property

Boiling point:: 483.8±40.0 °C(Predicted)
Density: 1.330±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
form: A solid
pka: 5.04±0.13(Predicted)
color: White to off-white

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-8001
Product name: PF-06260933
Purity: 98.41%
Packaging: 5mg
Price: $144
Updated: 2021/12/16

ChemScene

Product number: CS-8001
Product name: PF-06260933
Purity: 98.41%
Packaging: 10mg
Price: $228
Updated: 2021/12/16

ChemScene

Product number: CS-8001
Product name: PF-06260933
Purity: 98.41%
Packaging: 25mg
Price: $468
Updated: 2021/12/16

ChemScene

Product number: CS-8001
Product name: PF-06260933
Purity: 98.41%
Packaging: 50mg
Price: $660
Updated: 2021/12/16

ChemScene

Product number: CS-8001
Product name: PF-06260933
Purity: 98.41%
Packaging: 100mg
Price: $1020
Updated: 2021/12/16

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PF-6260933 Chemical Properties,Usage,Production

Biological Activity

PF-6260933 is a MAP4K4 inhibitor with IC50 of 3.7 nM and good kinome selectivity.

in vitro

PF-06260933 treatment of human aortic endothelial cell (EC) robustly prevents TNF-α-mediated endothelial permeability in vitro , similar to MAP4K4 knockdown.

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in vivo

In the mice model, PF-06260933 treatment does not alter plasma lipid content, although reductions in glucose levels are observed, which is consistent with whole-body-inducible Map4k4 knockout animals. PF-06260933 administration ameliorates further plaque development and/or promotes plaque regression in this animal model (46.0% versus 25.5%), and a reduction in plasma glucose as well as lipid content is also observed.

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target

Target	Value
MAP4K4 ()	3.7 nM

PF-6260933 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-6260933 Suppliers

China 39 United States 6 Global 45

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2992
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7267
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: lucy@atkchemical.com
Country: China
ProdList: 9204
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
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Email: sales@amadischem.com
Country: China
ProdList: 131957
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Medi-tech Bioscientific Co., Ltd.

Tel: 0519-83246372 13585352506
Fax: 0519-83246372
Country: China
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Twochem Co.Ltd.

Tel: 021-58111628 15800915896
Fax: QQ 3285589261
Email: sales@twochem.com
Country: China
ProdList: 1788
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Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3251
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1811510-56-1, PF-6260933Related Search:

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PF 06260933;PF06260933;PF6260933;PF 6260933;PF-6260933

PF-6260933

PF06260933

[3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-

inhibit,MAP4K,MAPK Kinase Kinase Kinase,PF 06260933,PF06260933,Inhibitor,PF-06260933

5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine

1811510-56-1