PF-6260933
- Product Name
- PF-6260933
- CAS No.
- 1811510-56-1
- Chemical Name
- PF-6260933
- Synonyms
- PF06260933;PF-6260933;5-(4-Chlorophenyl)-[3,3'-bipyridine]-6,6'-diamine;[3,3'-Bipyridine]-6,6'-diamine, 5-(4-chlorophenyl)-;PF 06260933;PF06260933;PF6260933;PF 6260933;PF-6260933;inhibit,MAP4K,MAPK Kinase Kinase Kinase,PF 06260933,PF06260933,Inhibitor,PF-06260933
- CBNumber
- CB53344890
- Molecular Formula
- C16H13ClN4
- Formula Weight
- 296.75
- MOL File
- 1811510-56-1.mol
PF-6260933 Property
- Boiling point:
- 483.8±40.0 °C(Predicted)
- Density
- 1.330±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol
- form
- A solid
- pka
- 5.04±0.13(Predicted)
- color
- White to off-white
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-8001
- Product name
- PF-06260933
- Purity
- 98.41%
- Packaging
- 5mg
- Price
- $144
- Updated
- 2021/12/16
- Product number
- CS-8001
- Product name
- PF-06260933
- Purity
- 98.41%
- Packaging
- 10mg
- Price
- $228
- Updated
- 2021/12/16
- Product number
- CS-8001
- Product name
- PF-06260933
- Purity
- 98.41%
- Packaging
- 25mg
- Price
- $468
- Updated
- 2021/12/16
- Product number
- CS-8001
- Product name
- PF-06260933
- Purity
- 98.41%
- Packaging
- 50mg
- Price
- $660
- Updated
- 2021/12/16
- Product number
- CS-8001
- Product name
- PF-06260933
- Purity
- 98.41%
- Packaging
- 100mg
- Price
- $1020
- Updated
- 2021/12/16
PF-6260933 Chemical Properties,Usage,Production
Biological Activity
PF-6260933 is a MAP4K4 inhibitor with IC50 of 3.7 nM and good kinome selectivity.
in vitro
PF-06260933 treatment of human aortic endothelial cell (EC) robustly prevents TNF-α-mediated endothelial permeability in vitro , similar to MAP4K4 knockdown.
< b>
in vivo
In the mice model, PF-06260933 treatment does not alter plasma lipid content, although reductions in glucose levels are observed, which is consistent with whole-body-inducible Map4k4 knockout animals. PF-06260933 administration ameliorates further plaque development and/or promotes plaque regression in this animal model (46.0% versus 25.5%), and a reduction in plasma glucose as well as lipid content is also observed.
p>
target
Target | Value |
MAP4K4 () | 3.7 nM |
PF-6260933 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-6260933 Suppliers
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