PF-06447475
- Product Name
- PF-06447475
- CAS No.
- 1527473-33-1
- Chemical Name
- PF-06447475
- Synonyms
- CS-1734;PF-06447475;PF-06447475, >98%;PF 06447475;PF06447475;3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile;3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile;3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-benzonitrile;Benzonitrile, 3-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-
- CBNumber
- CB52735532
- Molecular Formula
- C17H15N5O
- Formula Weight
- 305.33
- MOL File
- 1527473-33-1.mol
PF-06447475 Property
- Melting point:
- >223°C (dec.)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: soluble10mg/mL, clear
- pka
- 12.96±0.50(Predicted)
- form
- powder
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- 18375
- Product name
- PF-06447475
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 18375
- Product name
- PF-06447475
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 18375
- Product name
- PF-06447475
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $138
- Updated
- 2021/12/16
- Product number
- 18375
- Product name
- PF-06447475
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $313
- Updated
- 2021/12/16
- Product number
- 462312
- Product name
- PF 06447475
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
PF-06447475 Chemical Properties,Usage,Production
Uses
PF 06447475 is a highly potent LRRK2 kinase inhibitor. Highly selective, and mobile, it is used in the treatment of Parkinson’s disease which has been linked to Leucine rich repeat kinase 2 (LRRK2) enzymes.
Enzyme inhibitor
This potent, brain penetrant and selective LRRK2 inhibitor (FW = 305.44 g/mol; CAS 1527473-33-1), also named 3-[4-(4-morpholinyl)-7Hpyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile, targets Leucine-Rich Repeat Kinase 2, IC50 = 3 nM, (encoded by the PARK8 gene), which phosphorylates Akt1 (Ser-473), suggesting that Akt1 is a convincing candidate for the physiological substrate of LRRK2. Diseaseassociated mutations forms of LRRK2 (including Arg-1441-Cys, Gly-2019- Ser, and Ile-2020-Thr) exhibit reduced interaction with, and phosphorylation of, Akt1, a finding that suggests a possible mechanism for the neurodegeneration caused by LRRK2 mutations. Therapeutic approaches to slow or block the progression of Parkinson disease (PD) do not exist. Given that genetic and biochemical studies implicate α-synuclein and leucine-rich repeat kinase 2 (LRRK2) in late-onset PD. In wild-type rats as well as transgenic [Gly-2019-Ser]-LRRK2 rats that were injected intracranially with adeno-associated viral vectors expressing human α- synuclein in the substantia nigra, those expressing [Gly-2019-Ser]-LRRK2 show exacerbated dopaminergic neurodegeneration and inflammation in response to the overexpression of α-synuclein. Both neurodegeneration and neuroinflammation associated with [Gly-2019-Ser]-LRRK2 expression were mitigated by PF-06447475, which provided neuroprotection in wildtype rats. There are no adverse pathological indications in the lung, kidney, or liver of rats treated with PF-06447475. Pharmacological inhibition of LRRK2 is well tolerated for a 4-week period of time in rats and can counteract dopaminergic neurodegeneration caused by acute α-synuclein overexpression
PF-06447475 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-06447475 Suppliers
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View Lastest Price from PF-06447475 manufacturers
- Product
- PF-06447475 1527473-33-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%
- Supply Ability
- 20kg
- Release date
- 2019-09-05