ChemicalBook > CAS DataBase List > PF-06447475

PF-06447475

Product Name
PF-06447475
CAS No.
1527473-33-1
Chemical Name
PF-06447475
Synonyms
CS-1734;PF-06447475;PF-06447475, >98%;PF 06447475;PF06447475;3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile;3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile;3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-benzonitrile;Benzonitrile, 3-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-
CBNumber
CB52735532
Molecular Formula
C17H15N5O
Formula Weight
305.33
MOL File
1527473-33-1.mol
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PF-06447475 Property

Melting point:
>223°C (dec.)
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: soluble10mg/mL, clear
pka
12.96±0.50(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18375
Product name
PF-06447475
Purity
≥98%
Packaging
5mg
Price
$75
Updated
2021/12/16
Cayman Chemical
Product number
18375
Product name
PF-06447475
Purity
≥98%
Packaging
1mg
Price
$25
Updated
2021/12/16
Cayman Chemical
Product number
18375
Product name
PF-06447475
Purity
≥98%
Packaging
10mg
Price
$138
Updated
2021/12/16
Cayman Chemical
Product number
18375
Product name
PF-06447475
Purity
≥98%
Packaging
25mg
Price
$313
Updated
2021/12/16
Usbiological
Product number
462312
Product name
PF 06447475
Packaging
10mg
Price
$403
Updated
2021/12/16
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PF-06447475 Chemical Properties,Usage,Production

Uses

PF 06447475 is a highly potent LRRK2 kinase inhibitor. Highly selective, and mobile, it is used in the treatment of Parkinson’s disease which has been linked to Leucine rich repeat kinase 2 (LRRK2) enzymes.

Enzyme inhibitor

This potent, brain penetrant and selective LRRK2 inhibitor (FW = 305.44 g/mol; CAS 1527473-33-1), also named 3-[4-(4-morpholinyl)-7Hpyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile, targets Leucine-Rich Repeat Kinase 2, IC50 = 3 nM, (encoded by the PARK8 gene), which phosphorylates Akt1 (Ser-473), suggesting that Akt1 is a convincing candidate for the physiological substrate of LRRK2. Diseaseassociated mutations forms of LRRK2 (including Arg-1441-Cys, Gly-2019- Ser, and Ile-2020-Thr) exhibit reduced interaction with, and phosphorylation of, Akt1, a finding that suggests a possible mechanism for the neurodegeneration caused by LRRK2 mutations. Therapeutic approaches to slow or block the progression of Parkinson disease (PD) do not exist. Given that genetic and biochemical studies implicate α-synuclein and leucine-rich repeat kinase 2 (LRRK2) in late-onset PD. In wild-type rats as well as transgenic [Gly-2019-Ser]-LRRK2 rats that were injected intracranially with adeno-associated viral vectors expressing human α- synuclein in the substantia nigra, those expressing [Gly-2019-Ser]-LRRK2 show exacerbated dopaminergic neurodegeneration and inflammation in response to the overexpression of α-synuclein. Both neurodegeneration and neuroinflammation associated with [Gly-2019-Ser]-LRRK2 expression were mitigated by PF-06447475, which provided neuroprotection in wildtype rats. There are no adverse pathological indications in the lung, kidney, or liver of rats treated with PF-06447475. Pharmacological inhibition of LRRK2 is well tolerated for a 4-week period of time in rats and can counteract dopaminergic neurodegeneration caused by acute α-synuclein overexpression

PF-06447475 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF-06447475 Suppliers

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View Lastest Price from PF-06447475 manufacturers

Career Henan Chemical Co
Product
PF-06447475 1527473-33-1
Price
US $1.00/KG
Min. Order
1KG
Purity
97%
Supply Ability
20kg
Release date
2019-09-05

1527473-33-1, PF-06447475Related Search:

N-Methyl-N-[2-[[[2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)amino]-5-trifluoromethylpyrimidin-4-yl]amino]methyl]phenyl]methanesulfonamide PF 573228 PF-06882961 6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylicacid PF-04979064 PF-3758309 PF-05212384 PF-06281355 PF-562271 Ketohexokinase inhibitor 1 PF-6274484 PF-9366 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-(3R)-3-pyrrolidinylbenzamide 3-(5-fluoro-indol-3-yl)-pyrrolidine-2,5-dione PF06869206 PF-06700841 tosylate PF-06650833 1-((2S,5R)-5-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one

  • PF-06447475
  • 3-(4-morpholino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile
  • 3-[4-(4-Morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-benzonitrile
  • 3-(4-morpholin-4-yl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile
  • PF 06447475;PF06447475
  • CS-1734
  • PF-06447475, >98%
  • Benzonitrile, 3-[4-(4-morpholinyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-
  • 1527473-33-1
  • Inhibitors