T-2 TOXIN

ChemicalBook > CAS DataBase List > T-2 TOXIN

Product Name: T-2 TOXIN
CAS No.: 21259-20-1
Chemical Name: T-2 TOXIN
Synonyms: toxint2;Toxin T 2;hothecene;nsc138780;T-2 TOXIN;T-2 toxins;alerate[qr];FUSARITOXIN;t-2mycotoxin;Insariotoxin
CBNumber: CB6469458
Molecular Formula: C24H34O9
Formula Weight: 466.53
MOL File: 21259-20-1.mol

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T-2 TOXIN Property

Melting point:: 151.5℃
alpha: D26 +15° (c = 2.58 in ethanol)
Boiling point:: 489.35°C (rough estimate)
Density: 1.1942 (rough estimate)
refractive index: 1.6230 (estimate)
Flash point:: 2 °C
storage temp.: −20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml
form: powder
pka: 13.24±0.70(Predicted)
color: white
Merck: 13,9872
IARC: 3 (Vol. 31, Sup 7) 1987

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Safety

Hazard Codes: T+,T,Xn,F
Risk Statements: 26/27/28-38-36-20/21/22-11
Safety Statements: 28-36/37-45-36-26-16-36/37/39-22
RIDADR: UN 3462 6.1/PG 1
WGK Germany: 3
RTECS: YD0100000
F: 10-21
HazardClass: 6.1(a)
PackingGroup: I
HS Code: 29329990
Hazardous Substances Data: 21259-20-1(Hazardous Substances Data)
Toxicity: LD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11444
Product name: T-2 Toxin
Purity: ≥98%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 11444
Product name: T-2 Toxin
Purity: ≥98%
Packaging: 5mg
Price: $208
Updated: 2024/03/01

Usbiological

Product number: 021217
Product name: T-2 Toxin
Packaging: 1mg
Price: $263
Updated: 2021/12/16

Biosynth Carbosynth

Product number: BT162749
Product name: T2 Toxin
Packaging: 5mg
Price: $295
Updated: 2021/12/16

AK Scientific

Product number: 9088AJ
Product name: T-2Toxin
Packaging: 5mg
Price: $328
Updated: 2021/12/16

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T-2 TOXIN Chemical Properties,Usage,Production

Description

T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC₅₀ = 19.47), primary pig alveolar macrophages (PAMs). In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD₅₀s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.

Chemical Properties

White powder

Uses

T-2 Toxin is a tricothecene mycotoxin produced by fungi of the genus Fusarium. T-2 Toxin induces DNA damage and cell death on prolonged administration.

Definition

ChEBI: T-2 toxin is a trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals. It has a role as a mycotoxin, a cardiotoxic agent, a neurotoxin, an environmental contaminant, an apoptosis inducer, a DNA synthesis inhibitor and a fungal metabolite. It is a trichothecene, an acetate ester and an organic heterotetracyclic compound. It is functionally related to a HT-2 toxin.

General Description

T-2 Toxin is found to be a potent trichothecene mycotoxin produced by the genus fusarium fungi in feedstuffs and cereal grains.

Safety Profile

Poison by ingestion, intramuscular, subcutaneous, intraperitoneal, intracerebral, and intravenous routes. Moderately toxic by inhalation. Experimental teratogenic and reproductive effects. A skin irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

T-2 TOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from T-2 TOXIN manufacturers

Hebei Yanxi Chemical Co., Ltd.

Product: T-2 TOXIN 21259-20-1
Price: US $50.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10000
Release date: 2023-09-08

Career Henan Chemical Co

Product: T-2 TOXIN 21259-20-1
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg,5kg,50kg
Release date: 2020-01-18

21259-20-1, T-2 TOXINRelated Search:

Toxin HT 2,T-2, Toxin analog toxin,bluegreenalga,microcystisaeruginos 4-Methyl-2-(2-methyl-1-propenyl)tetrahydropyran (cis- and trans- mixture) TRANS-1,4-CYCLOHEXENEDIOL T-2 TOXIN DIACETOXYSCIRPENOL f-2toxi NEOSOLANIOL deacetyl-ht-2toxi scirpentriol T-2 TETRAOL VERRUCAROL gb2toxi entero-toxin(staphylococcusreduced PERTUSSIS TOXIN BRP DIPHTHERIA TOXIN BRP - * BIOTOX 1KTX SCORPION TOXIN SHK TOXIN

4β,15-Diacetoxy-8α-(3-Methylbutyryloxy)- 12,13-epoxytrichothec-9-en-3α-ol

8α-(3-Methylbutyryloxy)-4β,15- diacetoxyscirp-9-en-3α-ol

T-2 LienoMycin

T-2 Toxin, froM FusariuM tricinctuM

T-2 Toxin, 99%, from Fusarium tricinctum

12,13-epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol4,15-diacetate8

12,13-trichothecene

3alpha-Hydroxy-4beta,15-diacetoxy-8alpha(3-methylbutyryloxy)-12,13-epoxy-trichothec-9-ene

3alpha-hydroxy-4beta-15-diacetoxy-8alpha-(3-methylbutyryloxy)-12,13-epoxy-delt

3-hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta(sup9)-tric

3-hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-(sup9)-trich

3-hydroxy-4,15-diacetoxy-8-[3-methylbutyryloxy]-12,13-epoxytrichothec-9-ene

4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecen-3-ol

4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecen-3-ol[qr

4,15-diacetoxy-8-(3-methylbutyryloxy)scirp-9-en-3-ol

4-beta,15-diacetoxy-8-alpha-(3-methylbutyryloxy)-3-alpha-hydroxy-12,13-epoxy

4beta,8alpha,15-tetrol,12,13-epoxy-,4,15-diacetate8-trichothec-9-ene-3alph

8-(3-methylbutyryloxy)-diacetoxy-scirpeno

8-(3-Methylbutyryloxy)diacetoxyscirpenol

8-(3-methylbutyryloxy)-diacetoxyscirpenol

8-(3-methylbutyryloxy)-diacetoxyscirpenol[qr]

8alpha-(3-methylbutyryloxy)-4beta,15-diacetoxyscirp-9-en-3alpha-ol[qr]

8-isovalerate

a9-tricothecene[qr]

alerate[qr]

fusariotoxinet2

fusariotoxinet2[qr]

t(sub2)-trichothecene[qr]

t-2mycotoxin

t-2mycotoxin[qr]

t2-trichothecene[qr]

Toxin T 2

toxint2

trichothec-9-ene

Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)-

8alpha-(3-Methylbutyryloxy)-4beta,15-diacetoxyscirp-9-en-3alpha-ol

T2 Toxin / Fusariotoxin T 2 / Insariotoxin / Mycotoxin T 2

T-2 Toxin (T-2 Mycotoxin)

hothecene

Insariotoxin

insariotoxin[qr]

isaritoxin[qr]

-isovalerate

nsc138780

nsc138780[qr]

othecene[qr]

Scirpenol, 8-(3-methylbutyryloxy)-diacetoxy-

trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-,4,15-diacetate8-(3-methylbutan

Trichothec-9-ene-3alpha,4beta,8alpha,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate

trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol,12,13-epoxy-,4,15-diacetate

MYCOTOXIN TRICHOTHECENE 2

MYCOTOXIN T 2

T-2 TOXIN

(3-ALPHA, 4-BETA, 8-ALPHA)-TRICHOTHEC-9-ENE-3,4,8,15-TETROL,12,13-EPOXY-, 4,15-DIACETATE 8-(3-METHYLBUTANOATE)

4BETA,15-DIACETOXY-3ALPHA-HYDROXY-8ALPHA-[3-METHYLBUTYRYLOXY]-12,13-EPOXYTRICHOTHEC-9-ENE

100 ug/ml T-2 Toxin in ACN

FUSARIOTOXIN

FUSARIOTOXIN T 2