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T-2 TOXIN

Product Name
T-2 TOXIN
CAS No.
21259-20-1
Chemical Name
T-2 TOXIN
Synonyms
toxint2;Toxin T 2;hothecene;nsc138780;T-2 TOXIN;T-2 toxins;alerate[qr];FUSARITOXIN;t-2mycotoxin;Insariotoxin
CBNumber
CB6469458
Molecular Formula
C24H34O9
Formula Weight
466.52
MOL File
21259-20-1.mol
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T-2 TOXIN Property

Melting point:
151.5℃
alpha 
D26 +15° (c = 2.58 in ethanol)
Boiling point:
489.35°C (rough estimate)
Density 
1.1942 (rough estimate)
refractive index 
1.6230 (estimate)
Flash point:
2 °C
storage temp. 
−20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH7.2) (1:1): 0.5 mg/ml; Ethanol: 20 mg/ml
form 
powder
pka
13.24±0.70(Predicted)
color 
white
Merck 
13,9872
InChIKey
BXFOFFBJRFZBQZ-QYWOHJEZSA-N
SMILES
C[C@@]12[C@@H]([C@H]([C@@]([H])(O[C@]3([H])C=C([C@H](C[C@]13COC(=O)C)OC(=O)CC(C)C)C)[C@@]12OC1)O)OC(=O)C
IARC
3 (Vol. 31, Sup 7) 1987
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Safety

Hazard Codes 
T+,T,Xn,F
Risk Statements 
26/27/28-38-36-20/21/22-11
Safety Statements 
28-36/37-45-36-26-16-36/37/39-22
RIDADR 
UN 3462 6.1/PG 1
WGK Germany 
3
RTECS 
YD0100000
F 
10-21
HazardClass 
6.1(a)
PackingGroup 
I
HS Code 
29329990
Hazardous Substances Data
21259-20-1(Hazardous Substances Data)
Toxicity
LD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

Precautionary statements

P262Do not get in eyes, on skin, or on clothing.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
11444
Product name
T-2 Toxin
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
11444
Product name
T-2 Toxin
Purity
≥98%
Packaging
5mg
Price
$208
Updated
2024/03/01
Usbiological
Product number
021217
Product name
T-2 Toxin
Packaging
1mg
Price
$263
Updated
2021/12/16
Biosynth Carbosynth
Product number
BT162749
Product name
T2 Toxin
Packaging
5mg
Price
$295
Updated
2021/12/16
AK Scientific
Product number
9088AJ
Product name
T-2Toxin
Packaging
5mg
Price
$328
Updated
2021/12/16
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T-2 TOXIN Chemical Properties,Usage,Production

Description

T-2 toxin is a trichothecene mycotoxin that has been found in Fusarium. It binds to and inhibits peptidyltransferase in the 60S ribosomal subunit, inducing a ribotoxic stress response that triggers JNK and p38 MAPK signaling. T-2 toxin (3 nM) decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and nitric oxide (NO) in, and is cytotoxic to (IC50 = 19.47), primary pig alveolar macrophages (PAMs). In vivo, T-2 toxin induces production of reactive oxygen species (ROS), lipid peroxidation, and glutathione (GSH) depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg). It also induces hepatocyte apoptosis and dyslipidemias in mice. T-2 toxin has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage.

Chemical Properties

White powder

Uses

T-2 Toxin is a tricothecene mycotoxin produced by fungi of the genus Fusarium. T-2 Toxin induces DNA damage and cell death on prolonged administration.

Definition

ChEBI: T-2 toxin is a trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals. It has a role as a mycotoxin, a cardiotoxic agent, a neurotoxin, an environmental contaminant, an apoptosis inducer, a DNA synthesis inhibitor and a fungal metabolite. It is a trichothecene, an acetate ester and an organic heterotetracyclic compound. It is functionally related to a HT-2 toxin.

General Description

T-2 Toxin is found to be a potent trichothecene mycotoxin produced by the genus fusarium fungi in feedstuffs and cereal grains.

Safety Profile

Poison by ingestion, intramuscular, subcutaneous, intraperitoneal, intracerebral, and intravenous routes. Moderately toxic by inhalation. Experimental teratogenic and reproductive effects. A skin irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

References

[1] KUNIO DOI  Koji U. Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways.[J]. International Journal of Molecular Sciences, 2011, 12 8: 5213-5237. DOI: 10.3390/ijms12085213
[2] JULIE SEEBOTH. The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig.[J]. Veterinary Research, 2012: 35. DOI: 10.1186/1297-9716-43-35

T-2 TOXIN Preparation Products And Raw materials

Raw materials

Preparation Products

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T-2 TOXIN Suppliers

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View Lastest Price from T-2 TOXIN manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
T-2 TOXIN 21259-20-1
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10000
Release date
2023-09-08
Career Henan Chemical Co
Product
T-2 TOXIN 21259-20-1
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,50kg
Release date
2020-01-18

21259-20-1, T-2 TOXINRelated Search:

Toxin HT 2,T-2, Toxin analog toxin,bluegreenalga,microcystisaeruginos 4-Methyl-2-(2-methyl-1-propenyl)tetrahydropyran (cis- and trans- mixture) TRANS-1,4-CYCLOHEXENEDIOL T-2 TOXIN DIACETOXYSCIRPENOL f-2toxi NEOSOLANIOL deacetyl-ht-2toxi scirpentriol T-2 TETRAOL VERRUCAROL gb2toxi entero-toxin(staphylococcusreduced PERTUSSIS TOXIN BRP DIPHTHERIA TOXIN BRP - * BIOTOX 1KTX SCORPION TOXIN SHK TOXIN

  • 4β,15-Diacetoxy-8α-(3-Methylbutyryloxy)- 12,13-epoxytrichothec-9-en-3α-ol
  • 8α-(3-Methylbutyryloxy)-4β,15- diacetoxyscirp-9-en-3α-ol
  • T-2 LienoMycin
  • T-2 Toxin, froM FusariuM tricinctuM
  • T-2 Toxin, 99%, from Fusarium tricinctum
  • 12,13-epoxytrichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol4,15-diacetate8
  • 12,13-trichothecene
  • 3alpha-Hydroxy-4beta,15-diacetoxy-8alpha(3-methylbutyryloxy)-12,13-epoxy-trichothec-9-ene
  • 3alpha-hydroxy-4beta-15-diacetoxy-8alpha-(3-methylbutyryloxy)-12,13-epoxy-delt
  • 3-hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta(sup9)-tric
  • 3-hydroxy-4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-(sup9)-trich
  • 3-hydroxy-4,15-diacetoxy-8-[3-methylbutyryloxy]-12,13-epoxytrichothec-9-ene
  • 4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecen-3-ol
  • 4,15-diacetoxy-8-(3-methylbutyryloxy)-12,13-epoxy-delta-9-trichothecen-3-ol[qr
  • 4,15-diacetoxy-8-(3-methylbutyryloxy)scirp-9-en-3-ol
  • 4-beta,15-diacetoxy-8-alpha-(3-methylbutyryloxy)-3-alpha-hydroxy-12,13-epoxy
  • 4beta,8alpha,15-tetrol,12,13-epoxy-,4,15-diacetate8-trichothec-9-ene-3alph
  • 8-(3-methylbutyryloxy)-diacetoxy-scirpeno
  • 8-(3-Methylbutyryloxy)diacetoxyscirpenol
  • 8-(3-methylbutyryloxy)-diacetoxyscirpenol
  • 8-(3-methylbutyryloxy)-diacetoxyscirpenol[qr]
  • 8alpha-(3-methylbutyryloxy)-4beta,15-diacetoxyscirp-9-en-3alpha-ol[qr]
  • 8-isovalerate
  • a9-tricothecene[qr]
  • alerate[qr]
  • fusariotoxinet2
  • fusariotoxinet2[qr]
  • t(sub2)-trichothecene[qr]
  • t-2mycotoxin
  • t-2mycotoxin[qr]
  • t2-trichothecene[qr]
  • Toxin T 2
  • toxint2
  • trichothec-9-ene
  • Trichothec-9-ene-3,4,8,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-(3-methylbutanoate), (3alpha,4beta,8alpha)-
  • 8alpha-(3-Methylbutyryloxy)-4beta,15-diacetoxyscirp-9-en-3alpha-ol
  • T2 Toxin / Fusariotoxin T 2 / Insariotoxin / Mycotoxin T 2
  • T-2 Toxin (T-2 Mycotoxin)
  • hothecene
  • Insariotoxin
  • insariotoxin[qr]
  • isaritoxin[qr]
  • -isovalerate
  • nsc138780
  • nsc138780[qr]
  • othecene[qr]
  • Scirpenol, 8-(3-methylbutyryloxy)-diacetoxy-
  • trichothec-9-ene-3,4,8,15-tetrol,12,13-epoxy-,4,15-diacetate8-(3-methylbutan
  • Trichothec-9-ene-3alpha,4beta,8alpha,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate
  • trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol,12,13-epoxy-,4,15-diacetate
  • MYCOTOXIN TRICHOTHECENE 2
  • MYCOTOXIN T 2
  • T-2 TOXIN
  • (3-ALPHA, 4-BETA, 8-ALPHA)-TRICHOTHEC-9-ENE-3,4,8,15-TETROL,12,13-EPOXY-, 4,15-DIACETATE 8-(3-METHYLBUTANOATE)
  • 4BETA,15-DIACETOXY-3ALPHA-HYDROXY-8ALPHA-[3-METHYLBUTYRYLOXY]-12,13-EPOXYTRICHOTHEC-9-ENE
  • 100 ug/ml T-2 Toxin in ACN
  • FUSARIOTOXIN
  • FUSARIOTOXIN T 2