Difamilast

Product Name: Difamilast
CAS No.: 937782-05-3
Chemical Name: Difamilast
Synonyms: OPA15406);Difamilast;Difamilast (OPA-15406;Difamilast 937782-05-3;N-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)-2-ethoxybenzamide;N-[[2-[4-(difluoromethoxy)-3-propan-2-yloxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide;Benzamide, N-[[2-[4-(difluoromethoxy)-3-(1-methylethoxy)phenyl]-4-oxazolyl]methyl]-2-ethoxy-;Difamilast,PDE4,OPA 15406,Inhibitor,atopic,phosphodiesterase-4,OPA15406,Phosphodiesterase (PDE),OPA-15406,dermatitis,subtype,inhibit
CBNumber: CB64694667
Molecular Formula: C23H24F2N2O5
Formula Weight: 446.44
MOL File: 937782-05-3.mol

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Difamilast Property

Density: 1.223±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (223.99 mM; Need ultrasonic)
pka: 13.12±0.46(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C23H24F2N2O5/c1-4-29-18-8-6-5-7-17(18)21(28)26-12-16-13-30-22(27-16)15-9-10-19(32-23(24)25)20(11-15)31-14(2)3/h5-11,13-14,23H,4,12H2,1-3H3,(H,26,28)
InChIKey: VFBILHPIHUPBPZ-UHFFFAOYSA-N
SMILES: C(NCC1=COC(C2=CC=C(OC(F)F)C(OC(C)C)=C2)=N1)(=O)C1=CC=CC=C1OCC

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0039262
Product name: Difamilast
Purity: 99.20%
Packaging: 5mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0039262
Product name: Difamilast
Purity: 99.20%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0039262
Product name: Difamilast
Purity: 99.20%
Packaging: 25mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-0039262
Product name: Difamilast
Purity: 99.20%
Packaging: 50mg
Price: $3000
Updated: 2021/12/16

ChemScene

Product number: CS-0039262
Product name: Difamilast
Purity: 99.20%
Packaging: 100mg
Price: $4600
Updated: 2021/12/16

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Difamilast Chemical Properties,Usage,Production

Biological Activity

Difamilast is a novel atopic dermatitis drug candidate discovered by Otsuka that has phosphodiesterase 4 (PDE4) inhibitory activity.

in vitro

Difamilast has particularly efficient inhibition of subtype B (IC50=11.2 nM). It (OPA-15406) improves skin condition in relevant animal models of AD.

in vivo

Difamilast has particularly efficient inhibition of subtype B (IC50=11.2 nM). It (OPA-15406) improves skin condition in relevant animal models of AD.

Difamilast Preparation Products And Raw materials

Raw materials

Preparation Products

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Difamilast Suppliers

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937782-05-3, DifamilastRelated Search:

Difamilast 937782-05-3

Difamilast (OPA-15406

OPA15406)

Benzamide, N-[[2-[4-(difluoromethoxy)-3-(1-methylethoxy)phenyl]-4-oxazolyl]methyl]-2-ethoxy-

N-[[2-[4-(difluoromethoxy)-3-propan-2-yloxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide

Difamilast,PDE4,OPA 15406,Inhibitor,atopic,phosphodiesterase-4,OPA15406,Phosphodiesterase (PDE),OPA-15406,dermatitis,subtype,inhibit

Difamilast

N-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)-2-ethoxybenzamide

937782-05-3

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