Difamilast

Product Name: Difamilast
CAS No.: 937782-05-3
Chemical Name: Difamilast
Synonyms: OPA15406);Difamilast;Difamilast (OPA-15406;Difamilast 937782-05-3;N-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)-2-ethoxybenzamide;N-[[2-[4-(difluoromethoxy)-3-propan-2-yloxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide;Benzamide, N-[[2-[4-(difluoromethoxy)-3-(1-methylethoxy)phenyl]-4-oxazolyl]methyl]-2-ethoxy-;Difamilast,PDE4,OPA 15406,Inhibitor,atopic,phosphodiesterase-4,OPA15406,Phosphodiesterase (PDE),OPA-15406,dermatitis,subtype,inhibit
CBNumber: CB64694667
Molecular Formula: C23H24F2N2O5
Formula Weight: 446.44
MOL File: 937782-05-3.mol

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Difamilast Property

Density: 1.223±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (223.99 mM; Need ultrasonic)
pka: 13.12±0.46(Predicted)
form: Solid
color: White to off-white
InChI: InChI=1S/C23H24F2N2O5/c1-4-29-18-8-6-5-7-17(18)21(28)26-12-16-13-30-22(27-16)15-9-10-19(32-23(24)25)20(11-15)31-14(2)3/h5-11,13-14,23H,4,12H2,1-3H3,(H,26,28)
InChIKey: VFBILHPIHUPBPZ-UHFFFAOYSA-N
SMILES: C(NCC1=COC(C2=CC=C(OC(F)F)C(OC(C)C)=C2)=N1)(=O)C1=CC=CC=C1OCC

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0039262
Product name: Difamilast
Purity: 99.20%
Packaging: 5mg
Price: $500
Updated: 2021/12/16

ChemScene

Product number: CS-0039262
Product name: Difamilast
Purity: 99.20%
Packaging: 10mg
Price: $850
Updated: 2021/12/16

ChemScene

Product number: CS-0039262
Product name: Difamilast
Purity: 99.20%
Packaging: 25mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-0039262
Product name: Difamilast
Purity: 99.20%
Packaging: 50mg
Price: $3000
Updated: 2021/12/16

ChemScene

Product number: CS-0039262
Product name: Difamilast
Purity: 99.20%
Packaging: 100mg
Price: $4600
Updated: 2021/12/16

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Difamilast Chemical Properties,Usage,Production

Biological Activity

Difamilast is a novel atopic dermatitis drug candidate discovered by Otsuka that has phosphodiesterase 4 (PDE4) inhibitory activity.

in vitro

Difamilast has particularly efficient inhibition of subtype B (IC50=11.2 nM). It (OPA-15406) improves skin condition in relevant animal models of AD.

in vivo

Difamilast has particularly efficient inhibition of subtype B (IC50=11.2 nM). It (OPA-15406) improves skin condition in relevant animal models of AD.

Difamilast Preparation Products And Raw materials

Raw materials

Preparation Products

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Difamilast Suppliers

China 33 United States 1 Global 34

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Fax: +86-556-5032307
Email: wtx@bayeebio.com
Country: China
ProdList: 259
Advantage: 61

Hefei TianRui Pharmaceutical Chemistry Co., Ltd.

Tel: 0551-68933033 13956024211
Fax: 0551-68935833
Email: trchem@163.com
Country: China
ProdList: 87
Advantage: 58

Shanghai Yatan Pharmaceutical Research and Development Co. LTD

Tel: 021-58003085 15865876430
Fax: QQ1060196522
Email: hujy@neutanpharma.com
Country: China
ProdList: 173
Advantage: 58

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 19172
Advantage: 64

Zhengzhou HSH Science & Technology Co., Ltd.

Tel: 0371-55932928 18937192232
Fax: 0086-0371-55932928
Email: 1282296214@qq.com
Country: China
ProdList: 495
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
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Country: China
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Changzhou PBpharmaceutical R&D Co.,Ltd

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Shanghai Chaolan Chemical Technology Center

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Fax: 21-5161 9052
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Hubei widely chemical technology Co., Ltd.

Tel: 027-59402396 13419635609
Fax: 027-83989310
Email: 13419635609@163.com
Country: China
ProdList: 1973
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937782-05-3, DifamilastRelated Search:

Difamilast 937782-05-3

Difamilast (OPA-15406

OPA15406)

Benzamide, N-[[2-[4-(difluoromethoxy)-3-(1-methylethoxy)phenyl]-4-oxazolyl]methyl]-2-ethoxy-

N-[[2-[4-(difluoromethoxy)-3-propan-2-yloxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide

Difamilast,PDE4,OPA 15406,Inhibitor,atopic,phosphodiesterase-4,OPA15406,Phosphodiesterase (PDE),OPA-15406,dermatitis,subtype,inhibit

Difamilast

N-((2-(4-(difluoromethoxy)-3-isopropoxyphenyl)oxazol-4-yl)methyl)-2-ethoxybenzamide

937782-05-3

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