MAVS ANTIBODY
Source Reactivity Background References- Product Name
- MAVS ANTIBODY
- Chemical Name
- MAVS ANTIBODY
- Synonyms
- MAVS ANTIBODY
- CBNumber
- CB64731344
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb6356
- Product name
- MAVS antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb6356
- Product name
- MAVS antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
MAVS ANTIBODY Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Mouse;Rat
Background
The mitochondrial antiviral signaling protein contributes to innate immunity by triggering IRF-3 and NF-κB activation in response to viral infection, leading to the production of IFN-β. The MAVS protein contains an N-terminal CARD domain and a C-terminal mitochondrial transmembrane domain. The MAVS adaptor protein plays a critical and specific role in viral defenses. MAVS acts downstream of the RIG-I RNA helicase and viral RNA sensor, leading to the recruitment of IKKε, TRIF, and TRAF6. Some viruses have evolved strategies to circumvent these innate defenses by using proteases that cleave MAVS to prevent its mitochondrial localization.
References
[1] Seth, R.B. et al. (2005) Cell 122, 669-682.
[2] Sun, Q. et al. (2006) Immunity 24, 633-642.
[3] Xu, L.G. et al. (2005) Mol. Cell 19, 727-740.
[4] Yoneyama, M. et al. (2004) Nat. Immunol. 5, 730-737.
[5] Lin, R. et al. (2006) J. Virol. 80, 6072-6083.
[6] Chen, Z. et al. (2007) J. Virol. 81, 964-976.
MAVS ANTIBODY Preparation Products And Raw materials
Raw materials
Preparation Products
MAVS ANTIBODY Suppliers
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