Applications Immunogen Background

PDCD4 ANTIBODY

Applications Immunogen Background
Product Name
PDCD4 ANTIBODY
Chemical Name
PDCD4 ANTIBODY
Synonyms
PDCD4 ANTIBODY
CBNumber
CB64731405
Formula Weight
0
MOL File
Mol file
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb11247
Product name
PDCD4 antibody
Purity
Affinity purified by Protein A
Packaging
100μg
Price
$421.6
Updated
2021/12/16
Biorbyt Ltd
Product number
orb11247
Product name
PDCD4 antibody
Purity
Affinity purified by Protein A
Packaging
200μg
Price
$673.2
Updated
2021/12/16
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PDCD4 ANTIBODY Chemical Properties,Usage,Production

Applications

PDCD4 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Recommended dilution range for Western blot analysis is 1:1,000~ 3,000. Recommended starting dilution is 1:2,000.

Immunogen

Anti-human PDCD4 mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PDCD4 amino acids 1-469 purified from E. coli.

Background

PDCD4 is restricted to the nucleus in proliferating cells. Expression of PDCD4 is modulated by cytokines in natural killer and T cells. PDCD4 takes part in apoptosis. PDCD4 is a translation inhibitor targeted for degradation during tumor promotion. PDCD4 promotes colonic neoplastic transformation and tumor invasion. PDCD4 is an important target for microrna R-21 in breast cancer cells. Shortage of PDCD4 expression is associated with colorectal cancer. PDCD4 is swiftly phosphorylated by S6K1 kinase protein & afterwords degraded by ubiquitin ligase SCF in response to mitogens. PDCD4 in response to mitogens allows competent protein synthesis & cell growth. PDCD4 is a proapoptotic protein involved in TGF-beta1-induced apoptosis in human HCC cells, and a tumor suppressor in hepatocarcinogenesis. PDCD4 restraines tumor progression in colon carcinoma cells by the novel mechanism of down-regulating MAP4K1 transcription, with consequent inhibition of c-Jun activation and AP-1-dependent transcri

PDCD4 ANTIBODY Preparation Products And Raw materials

Raw materials

Preparation Products

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PDCD4 ANTIBODY Suppliers

China 76 Japan 1 Global 77
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  • PDCD4 ANTIBODY