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N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE

Product Name
N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
CAS No.
261766-23-8
Chemical Name
N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
Synonyms
N-4AIA;N-4ACETIA;N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE;N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-;N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
CBNumber
CB6475024
Molecular Formula
C27H24ClN3O4
Formula Weight
489.95
MOL File
Mol file
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N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Property

Melting point:
256-257°C
storage temp. 
−20°C
solubility 
DMSO: ≥15 mg/mL
form 
crystalline
color 
Pale Yellow
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
70278
Product name
N-(4-acetamidophenyl)-Indomethacin amide
Purity
≥98%
Packaging
1mg
Price
$18
Updated
2024/03/01
Cayman Chemical
Product number
70278
Product name
N-(4-acetamidophenyl)-Indomethacin amide
Purity
≥98%
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
70278
Product name
N-(4-acetamidophenyl)-Indomethacin amide
Purity
≥98%
Packaging
10mg
Price
$129
Updated
2024/03/01
Cayman Chemical
Product number
70278
Product name
N-(4-acetamidophenyl)-Indomethacin amide
Purity
≥98%
Packaging
50mg
Price
$553
Updated
2024/03/01
TRC
Product number
A161150
Product name
N-(4-Acetamidophenyl)indomethacinAmide
Packaging
5mg
Price
$55
Updated
2021/12/16
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N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Chemical Properties,Usage,Production

Description

N-(4-acetamidophenyl)-indomethacin amide (N-4-AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-4-AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.12 and 0.625 μM, respectively. It is about 400 times less potent as an inhibitor of human recombinant COX-1 and 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.

Chemical Properties

Pale Yellow Solid

Uses

An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.1 uM and 0.625 uM, respectively

Definition

ChEBI: N-(4-acetamidophenyl)-Indomethacin amide is a N-acylindole.

References

[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Suppliers

Canada 1 China 10 India 1 Switzerland 1 United Kingdom 1 United States 7 Global 21
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261766-23-8, N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDERelated Search:

5-METHOXY-2-METHYLINDOLE

  • N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE
  • N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE
  • N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
  • N-4ACETIA
  • N-4AIA
  • N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
  • 1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
  • 261766-23-8
  • C27H24N3O4Cl
  • C27H24ClN3O4
  • Biochemicals and Reagents
  • BioChemical
  • Application Index
  • Cell Signaling Enzymes
  • Cyclooxygenase Inhibitors
  • Cyclooxygenase (COX) Enzymes
  • Enzymes, Inhibitors, and Substrates
  • Inhibitors
  • Aromatics
  • Heterocycles