ChemicalBook > CAS DataBase List > N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE

Product Name
N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
CAS No.
261766-23-8
Chemical Name
N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
Synonyms
N-4AIA;N-4ACETIA;N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE;N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-;N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
CBNumber
CB6475024
Molecular Formula
C27H24ClN3O4
Formula Weight
489.95
MOL File
Mol file
More
Less

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Property

Melting point:
256-257°C
storage temp. 
−20°C
solubility 
DMSO: ≥15 mg/mL
form 
crystalline
color 
Pale Yellow
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
70278
Product name
N-(4-acetamidophenyl)-Indomethacin amide
Purity
≥98%
Packaging
1mg
Price
$18
Updated
2024/03/01
Cayman Chemical
Product number
70278
Product name
N-(4-acetamidophenyl)-Indomethacin amide
Purity
≥98%
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
70278
Product name
N-(4-acetamidophenyl)-Indomethacin amide
Purity
≥98%
Packaging
10mg
Price
$129
Updated
2024/03/01
Cayman Chemical
Product number
70278
Product name
N-(4-acetamidophenyl)-Indomethacin amide
Purity
≥98%
Packaging
50mg
Price
$553
Updated
2024/03/01
TRC
Product number
A161150
Product name
N-(4-Acetamidophenyl)indomethacinAmide
Packaging
5mg
Price
$55
Updated
2021/12/16
More
Less

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Chemical Properties,Usage,Production

Description

N-(4-acetamidophenyl)-indomethacin amide (N-4-AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-4-AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.12 and 0.625 μM, respectively. It is about 400 times less potent as an inhibitor of human recombinant COX-1 and 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.

Chemical Properties

Pale Yellow Solid

Uses

An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.1 uM and 0.625 uM, respectively

Definition

ChEBI: N-(4-acetamidophenyl)-Indomethacin amide is a N-acylindole.

References

[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Suppliers

Canada 1 China 16 India 1 Switzerland 1 United Kingdom 1 United States 7 Global 27
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4720
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Santa Cruz Biotechnology Inc
Tel
021-60936350
Email
scbt@scbt.com
Country
China
ProdList
6594
Advantage
58
Shenzhen Science Biology Co., Ltd.
Tel
18617181553
Country
CHINA
ProdList
112
Advantage
58
Guangzhou Qingyan Biotechnology Co., Ltd.
Tel
19802084049
Country
CHINA
ProdList
171
Advantage
58
Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6207
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Advanced Technology & Industrial Co., Ltd.
Tel
--
Fax
--
Email
sales@advtechind.com
Country
China
ProdList
6523
Advantage
75

261766-23-8, N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDERelated Search:

5-METHOXY-2-METHYLINDOLE

  • N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE
  • N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE
  • N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
  • N-4ACETIA
  • N-4AIA
  • N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
  • 1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
  • 261766-23-8
  • C27H24N3O4Cl
  • C27H24ClN3O4
  • Biochemicals and Reagents
  • BioChemical
  • Application Index
  • Cell Signaling Enzymes
  • Cyclooxygenase Inhibitors
  • Cyclooxygenase (COX) Enzymes
  • Enzymes, Inhibitors, and Substrates
  • Inhibitors
  • Aromatics
  • Heterocycles