ChemicalBook > CAS DataBase List > ORY-1001(trans)
ORY-1001(trans)
- Product Name
- ORY-1001(trans)
- CAS No.
- 1431303-72-8
- Chemical Name
- ORY-1001(trans)
- Synonyms
- Ladademstat;ORY-1001(trans);ORY1001 HCl salt;ORY-1001(Ladademstat);ORY-1001 dihydrochloride;Iadademstat dihydrochloride;Iadademstat dihydrochloride, 10 mM in DMSO;(1r,4R)-N1-((1R,2S)-2-phenylcyclopropyl)cyclohexane-1,4-diamine;trans-N1-((1R,2S)-2-Phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride;RO 7051790,RG 6016,Iadademstat dihydrochloride,Histone Demethylase,Iadademstat,RO7051790,inhibit,RG6016,Inhibitor,ORY1001,RO-7051790,ORY 1001,ORY-1001,RG-6016
- CBNumber
- CB64796675
- Molecular Formula
- C15H23ClN2
- Formula Weight
- 266.81
- MOL File
- 1431303-72-8.mol
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ORY-1001(trans) Property
- storage temp.
- Store at -20°C
- solubility
- Water: 57.75 mg/mL (190.42 mM and warming); DMSO: 0.69 mg/mL (2.28 mM and warming)
- form
- Solid
- color
- White to off-white
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0044434
- Product name
- ORY-1001(trans)
- Purity
- 98.30%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0044434
- Product name
- ORY-1001(trans)
- Purity
- 98.30%
- Packaging
- 10mg
- Price
- $180
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0044434
- Product name
- ORY-1001(trans)
- Purity
- 98.30%
- Packaging
- 50mg
- Price
- $700
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0044434
- Product name
- ORY-1001(trans)
- Purity
- 98.30%
- Packaging
- 100mg
- Price
- $1200
- Updated
- 2021/12/16
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ORY-1001(trans) Chemical Properties,Usage,Production
Uses
Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor.
in vivo
Iadademstat reduces AML tumor growth in mice and rat xenografts and increases survival time in a disseminated model of T-ALL[1].
References
[1] Maes T, et al. KDM1 histone lysine demethylases as targets for treatments of oncological and neurodegenerative disease. Epigenomics. 2015;7(4):609-26. doi: 10.2217/epi.15.9. DOI:10.2217/epi.15.9
[2] Tamara Maes, et al. ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia. Cancer Cell. 2018 Mar 12;33(3):495-511.e12. DOI:10.1016/j.ccell.2018.02.002
ORY-1001(trans) Preparation Products And Raw materials
Raw materials
Preparation Products
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ORY-1001(trans) Suppliers
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58
- Tel
- +1-781-999-5354;
- support@targetmol.com
- Country
- United States
- ProdList
- 39035
- Advantage
- 58