CUCURBITACIN I
- Product Name
- CUCURBITACIN I
- CAS No.
- 2222-07-3
- Chemical Name
- CUCURBITACIN I
- Synonyms
- JSI-124;Ibamarin;ELATERIN B;NSC 521777;ELATERICIN B;CUCURBITACIN I;5-tetrahydroxy-;cucurbitacine(i);Cucurbitacin I-RM;CUCURBITACIN I(SH)
- CBNumber
- CB6480840
- Molecular Formula
- C30H42O7
- Formula Weight
- 514.65
- MOL File
- 2222-07-3.mol
CUCURBITACIN I Property
- Melting point:
- 148-150°C
- Boiling point:
- 698.3±55.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- ≥22.45 mg/mL in DMSO; insoluble in EtOH; ≥51.2 mg/mL in H2O with ultrasonic
- form
- solid
- pka
- 8.51±0.70(Predicted)
- color
- white to off-white
- LogP
- 2.330 (est)
Safety
- Hazard Codes
- Xi,T+
- Risk Statements
- 25-28
- Safety Statements
- 1-22-45-36/37-28
- RIDADR
- UN 2811 6.1/PG 1
- WGK Germany
- 3
- RTECS
- RC6200000
- Toxicity
- LD50 oral in mouse: 5mg/kg
N-Bromosuccinimide Price
- Product number
- PHL89464
- Product name
- Cucurbitacin I
- Purity
- phyproof? Reference Substance
- Packaging
- 10MG
- Price
- $598
- Updated
- 2024/03/01
- Product number
- C4493
- Product name
- Cucurbitacin I hydrate
- Purity
- ≥95% (HPLC), solid
- Packaging
- 1mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 238590
- Product name
- Cucurbitacin I, Cucumis sativus L.
- Purity
- A cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that displays anti-proliferative and antitumor properties both in vitro and in vivo.
- Packaging
- 1MG
- Price
- $289
- Updated
- 2024/03/01
- Product number
- 14747
- Product name
- Cucurbitacin I
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 14747
- Product name
- Cucurbitacin I
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $238
- Updated
- 2024/03/01
CUCURBITACIN I Chemical Properties,Usage,Production
Description
Cucurbitacin I is a naturally occurring tetracyclic triterpenoid compound with a variety of physiological effects, including induction of apoptosis and blockade of cell cycle progression in various cancer cells. It has also been shown to have anti-angiogenic activity. Cucurbitacin I inhibits the phosphorylation of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1, which are key regulators of endothelial cell function and angiogenesis. Therefore, Cucurbitacin I is considered a potential angiogenesis inhibitor candidate for cancer therapy[1].
Uses
Cucurbitacin I can be useful in the study of edible vitalmelon fruit extract and adipogenesis.
Definition
ChEBI: Cucurbitacin I is a cucurbitacin that is 9,10,14-trimethyl-4,9-cyclo-9,10-secocholesta-2,5,23-triene substituted by hydroxy groups at positions 2, 16, 20 and 25 and oxo groups at positions 1, 11 and 22. It has a role as a plant metabolite and an antineoplastic agent. It is a cucurbitacin and a tertiary alpha-hydroxy ketone.
Biological Activity
Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3.
Biochem/physiol Actions
Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties.
storage
Store at -20°C
References
[1] HYEON JIN KIM Jin K K. Antiangiogenic effects of cucurbitacin-I[J]. Archives of Pharmacal Research, 2014. DOI:10.1007/s12272-014-0386-5.
blaskovich ma, sun j, cantor a et al. discovery of jsi-124 (cucurbitacin i), a selective janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.cancer res. 2003 mar 15;63(6):1270-9.yu h, lee h, herrmann a et al. revisiting stat3 signalling in cancer: new and unexpected biological functions.nat rev cancer. 2014 nov;14(11):736-46. doi: 10.1038/nrc3818.song j, liu h, li z et al. cucurbitacin i inhibits cell migration and invasion and enhances chemosensitivity in colon cancer. oncol rep. 2015 apr;33(4):1867-71. qi j, xia g, huang cr et al. jsi-124 (cucurbitacin i) inhibits tumor angiogenesis of human breast cancer through reduction of stat3 phosphorylation. am j chin med. 2015;43(2):337-47.kim hj, kim jk et al. antiangiogenic effects of cucurbitacin-i. arch pharm res. 2015 feb;38(2):290-8. yuan g, yan sf, xue h et al. cucurbitacin i induces protective autophagy in glioblastoma in vitro and in vivo. j biol chem. 2014 apr 11;289(15):10607-19.
CUCURBITACIN I Preparation Products And Raw materials
Raw materials
Preparation Products
CUCURBITACIN I Suppliers
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View Lastest Price from CUCURBITACIN I manufacturers
- Product
- CUCURBITACIN I 2222-07-3
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-20