Cucurbitacin E
- Product Name
- Cucurbitacin E
- CAS No.
- 18444-66-1
- Chemical Name
- Cucurbitacin E
- Synonyms
- 25-acetate;A-ELATERIN;Cucurbit E;α-Elaterine;Cucurbitine E;CUCURBITACIN E;ALPHA-ELATERIN;cucurbitacine-e;alpha-elaterine;Cucurbitacin E(P)
- CBNumber
- CB3372306
- Molecular Formula
- C32H44O8
- Formula Weight
- 556.69
- MOL File
- 18444-66-1.mol
Cucurbitacin E Property
- Melting point:
- 228-234°C
- alpha
- D -59° (c = 0.7 in chloroform)
- Boiling point:
- 545.56°C (rough estimate)
- Density
- 1.1059 (rough estimate)
- refractive index
- 1.4900 (estimate)
- storage temp.
- -20°C
- solubility
- DMSO: soluble15mg/mL, clear
- form
- powder
- pka
- 8.51±0.70(Predicted)
- color
- white to beige
- optical activity
- [α]/D -60 to -75°, c = 0.7 (CDCl3)
- InChIKey
- NDYMQXYDSVBNLL-MUYMLXPFSA-N
- LogP
- 3.150 (est)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 25-22
- Safety Statements
- 1-22-45-24/25
- RIDADR
- 3172
- WGK Germany
- 3
- RTECS
- RC6305500
- HS Code
- 29153900
- Toxicity
- LD50 orally in mice: 340 mg/kg (Albert)
N-Bromosuccinimide Price
- Product number
- SML0577
- Product name
- Cucurbitacin E
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $206
- Updated
- 2024/03/01
- Product number
- SML0577
- Product name
- Cucurbitacin E
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $955
- Updated
- 2023/01/07
- Product number
- 14821
- Product name
- Cucurbitacin E
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $41
- Updated
- 2024/03/01
- Product number
- 14821
- Product name
- Cucurbitacin E
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $162
- Updated
- 2024/03/01
- Product number
- 14821
- Product name
- Cucurbitacin E
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $302
- Updated
- 2024/03/01
Cucurbitacin E Chemical Properties,Usage,Production
Description
Cucurbitacin E is a plant-derived triterpene that has diverse biological activities. At a concentration of 10 pM, it reduces MPP+-induced death of neuronal PC12 cells through inhibition of autophagy in vitro. Cucurbitacin E inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC50s = 50-1,000 nM) through induction of G2/M arrest and apoptosis. It increases bilirubin binding to human serum albumin (HSA) in human plasma in a dose-dependent manner. Cucurbitacin E also inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells.
Chemical Properties
white to beige powder
Uses
Cucurbitacin E has been used as a cofilin inhibitor. It is also used as a F-actin stabilizer to prevent membrane-associated periodic skeleton (MPS) loss and protect from axonal fragmentation.
Uses
Cucurbitacin E is a biochemical compound from the family of Cucurbitacins. Cucurbitacin E is a highly oxidated steroid consisting of a tetracyclic triterpene. Cucurbitacin E is known to possess broad spectrum of potential anti-inflammatory, antitumor andantioxidant effects.
Definition
ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG.
Biochem/physiol Actions
Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation.
Cucurbitacin E Preparation Products And Raw materials
Raw materials
Preparation Products
Cucurbitacin E Suppliers
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View Lastest Price from Cucurbitacin E manufacturers
- Product
- Cucurbitacin E 18444-66-1
- Price
- US $0.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2020-03-12
- Product
- Cucurbitacin E 18444-66-1 18444-66-1
- Price
- US $255.00/mg
- Min. Order
- 20mg
- Purity
- ≥98%
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-11
- Product
- Cucurbitacin E 18444-66-1
- Price
- US $285.00/mg
- Min. Order
- 20mg
- Purity
- 99%
- Supply Ability
- 10kg
- Release date
- 2021-06-08