Cucurbitacin E

ChemicalBook > CAS DataBase List > Cucurbitacin E

Product Name: Cucurbitacin E
CAS No.: 18444-66-1
Chemical Name: Cucurbitacin E
Synonyms: 25-acetate;A-ELATERIN;Cucurbit E;α-Elaterine;Cucurbitine E;CUCURBITACIN E;ALPHA-ELATERIN;cucurbitacine-e;alpha-elaterine;CUCURBITACIN E(SH)
CBNumber: CB3372306
Molecular Formula: C32H44O8
Formula Weight: 556.69
MOL File: 18444-66-1.mol

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Cucurbitacin E Property

Melting point:: 228-234°C
alpha: D -59° (c = 0.7 in chloroform)
Boiling point:: 545.56°C (rough estimate)
Density: 1.1059 (rough estimate)
refractive index: 1.4900 (estimate)
storage temp.: -20°C
solubility: DMSO: soluble15mg/mL, clear
form: powder
pka: 8.51±0.70(Predicted)
color: white to beige
optical activity: [α]/D -60 to -75°, c = 0.7 (CDCl3)
InChIKey: NDYMQXYDSVBNLL-MUYMLXPFSA-N
LogP: 3.150 (est)

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Safety

Hazard Codes: Xn
Risk Statements: 25-22
Safety Statements: 1-22-45-24/25
RIDADR: 3172
WGK Germany: 3
RTECS: RC6305500
HS Code: 29153900
Toxicity: LD50 orally in mice: 340 mg/kg (Albert)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0577
Product name: Cucurbitacin E
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $206
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0577
Product name: Cucurbitacin E
Purity: ≥95% (HPLC)
Packaging: 25mg
Price: $955
Updated: 2023/01/07

Cayman Chemical

Product number: 14821
Product name: Cucurbitacin E
Purity: ≥98%
Packaging: 1mg
Price: $41
Updated: 2024/03/01

Cayman Chemical

Product number: 14821
Product name: Cucurbitacin E
Purity: ≥98%
Packaging: 5mg
Price: $162
Updated: 2024/03/01

Cayman Chemical

Product number: 14821
Product name: Cucurbitacin E
Purity: ≥98%
Packaging: 10mg
Price: $302
Updated: 2024/03/01

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Cucurbitacin E Chemical Properties,Usage,Production

Description

Cucurbitacin E is a plant-derived triterpene that has diverse biological activities. At a concentration of 10 pM, it reduces MPP⁺-induced death of neuronal PC12 cells through inhibition of autophagy in vitro. Cucurbitacin E inhibits growth of T24 bladder, MDA-MB-468 and MCF-7 breast, PC3 prostate, and colorectal cancer cell lines (IC₅₀s = 50-1,000 nM) through induction of G₂/M arrest and apoptosis. It increases bilirubin binding to human serum albumin (HSA) in human plasma in a dose-dependent manner. Cucurbitacin E also inhibits depolymerization of actin filaments isolated from rabbit skeletal muscle actin and in HeLa cells.

Chemical Properties

white to beige powder

Uses

Cucurbitacin E has been used as a cofilin inhibitor. It is also used as a F-actin stabilizer to prevent membrane-associated periodic skeleton (MPS) loss and protect from axonal fragmentation.

Uses

Cucurbitacin E is a biochemical compound from the family of Cucurbitacins. Cucurbitacin E is a highly oxidated steroid consisting of a tetracyclic triterpene. Cucurbitacin E is known to possess broad spectrum of potential anti-inflammatory, antitumor andantioxidant effects.

Definition

ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG.

Biochem/physiol Actions

Cucurbitacin E is a potent inhibitor of actin depolymerization. Cucurbitacin E is more active than jasplakinolide, and has a different mechanism of action, binding to a different site. Cucurbitacin E binds specifically to filamentous actin (F-actin) forming a covalent bond at residue Cys257, but not to monomeric actin (G-actin), stabilizing F-actin, without affecting actin polymerization or nucleation.

Cucurbitacin E Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cucurbitacin E manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Cucurbitacin E 18444-66-1
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-12

NanJing Spring & Autumn Biological Engineering CO., LTD.

Product: Cucurbitacin E 18444-66-1 18444-66-1
Price: US $255.00/mg
Min. Order: 20mg
Purity: ≥98%
Supply Ability: 1000.00 kgs
Release date: 2019-07-11

Baoji Guokang Healthchem co.,ltd

Product: Cucurbitacin E 18444-66-1
Price: US $285.00/mg
Min. Order: 20mg
Purity: 99%
Supply Ability: 10kg
Release date: 2021-06-08

18444-66-1, Cucurbitacin ERelated Search:

Cucurbitacin,CUCURBITACIN B(RG),CUCURBITACIN B Cucurbitacin C CUCURBITACIN D,CUCURBITACIN D WITH HPLC 1,2-Cyclohexanedione 2,6-Dimethyl-5-heptenal ADOXAL Calebassine FITONE CUCURBITACIN D(SH) Cucurbitacin IIb CUCURBITACIN IIA CUCURBITACIN I hplc,CUCURBITACIN I WITH HPLC,Cucurbitacin I hydrate,CUCURBITACIN I(SH),CUCURBITACIN I Cucurbitacin Ia,Cucurbitacin F-25-acetate Cucurbitacin A Cucurbitacin L Cucurbitacin F dihydrocucurbitacin F Cucurbitacin H,24-epi-Cucurbitacin G,Cucurbitacin G

A-ELATERIN

ALPHA-ELATERIN

CUCURBITACIN E

CUCURBITACIN E(SH)

19-nor-9-beta,10-alpha-lanosta-1,5,23-triene-3,11,22-trione,2,16-alpha,20,25-t

25-acetate

alpha-elaterine

cucurbitacine-e

2,16alpha,20,25-tetrahydroxy-9beta-methyl-10alpha,-19-norlanosta-1,5,23(E)-triene-3,11,22-trione 25-acetate

CUCURBITACIN E WITH HPLC

[(E,6R)-6-[(8S,9R,10R,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-8,10,12,15,16,17-hexahydro-7H-cyclopenta[a]phenanthren-17-yl]-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl] acetate

(10α,23E)-25-(Acetyloxy)-2,16α,20-trihydroxy-9β-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione

CUCURBITACIN E hplc

(9β,10α,23E)-25-(Acetyloxy)-2,16α,20-trihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione

(9β,10α,23E)-25-Acetyloxy-2,16α,20-trihydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione

α-Elaterine

Cucurbitacin E, 98%, from Cucumis melo L.

Cucurbit E

Cucurbitacin E 18444-66-1

Cucurbitacin E, >99%

Cucurbitacin E (α-Elaterin

2,16α,20,25-tetrahydroxy-9β-methyl-10α,-19-norlanosta-1,5,23(E)-triene-3,11,22-trione 25-acetate

19-Norlanosta-1,5,23-triene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (9β,10α,16α,23E)-

Cucurbitacin E USP/EP/BP

2,16α,20,25-tetrahydroxy-9β-methyl-10α,-19-norlanosta-1,5...

2,16α,20,25-tetrahydroxy-9β-methyl-10α,-19-norlanosta-1,5,23(E)-triene-3,11,22-trione 25-acetate

(R,E)-6-((8S,9R,10R,13R,14S,16R,17R)-2,16-Dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-4,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate

Cucurbitine E

18444-66-1

C32H44O8

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Tri-Terpenoids