CUCURBITACIN B

Product Name: CUCURBITACIN B
CAS No.: 6199-67-3
Chemical Name: CUCURBITACIN B
Synonyms: Cuc B;AMARINE;HSDB 3476;DATISCACIN;NSC-144154;heMsecin A;Cucurbitacin;cucuritacin B;cucurbitacineb;CUCURBITACIN B
CBNumber: CB5113260
Molecular Formula: C32H46O8
Formula Weight: 558.7
MOL File: 6199-67-3.mol

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CUCURBITACIN B Property

Melting point:: 184-186°
alpha: D25 +88° (c = 1.55 in ethanol)
Boiling point:: 546.74°C (rough estimate)
Density: 1.0953 (rough estimate)
refractive index: 1.4900 (estimate)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
pka: 12.60±0.29(Predicted)
color: white to beige
λmax: 290nm(EtOH)(lit.)
Merck: 14,2614
Stability:: Hygroscopic
InChIKey: IXQKXEUSCPEQRD-ALLWXVAWSA-N

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45-24/25
RIDADR: UN 2811 6.1 / PGI
WGK Germany: 3
RTECS: RC6190000
HazardClass: 6.1
PackingGroup: II
HS Code: 29153900
Hazardous Substances Data: 6199-67-3(Hazardous Substances Data)
Toxicity: LD10 orally in mice: 5 mg/kg (LeMen)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C8499
Product name: Cucurbitacin B hydrate
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $256
Updated: 2024/03/01

Sigma-Aldrich

Product number: C8499
Product name: Cucurbitacin B hydrate
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $1020
Updated: 2024/03/01

TCI Chemical

Product number: C3442
Product name: Cucurbitacin B
Purity: >98.0%(HPLC)
Packaging: 5mg
Price: $158
Updated: 2024/03/01

TCI Chemical

Product number: C3442
Product name: Cucurbitacin B
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $478
Updated: 2024/03/01

Cayman Chemical

Product number: 14820
Product name: Cucurbitacin B
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

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CUCURBITACIN B Chemical Properties,Usage,Production

Description

Cucurbitacin B is a tetracyclic triterpenoid that has been shown to have a strong antitumor activity.

Chemical Properties

White solid

Uses

Cucurbitacin B hydrate has been used:

as a signal transducer and activator of transcription 3 (stat3) inhibitor to determine its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs).
as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydoxyecdysone (20E) signaling in butterflies.
to determine its effect on the cell viability of pancreatic cancer cell lines.

Definition

ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.

Biochem/physiol Actions

Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I.

CUCURBITACIN B Preparation Products And Raw materials

Raw materials

Preparation Products

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CUCURBITACIN B Suppliers

Americas 1 China 229 Europe 1 India 2 Japan 1 United Kingdom 3 United States 22 USA 1 Global 260

Hubei wei shi reagent group ltd., company

Tel: 027-59101766 13125137661
Email: 2853877621@qq.com
Country: China
ProdList: 3019
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24539
Advantage: 81

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 17987
Advantage: 64

BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11726
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7815
Advantage: 57

Aktin Chemicals, Inc.

Tel: 86-28-85159085
Fax: 86-28-85152372
Email: info@aktinchem.com
Country: China
ProdList: 297
Advantage: 62

TIPR Pharmaceutical Responsible Co., Ltd.

Tel: 022-23009155 23006946
Fax: 022-27454635
Email: api@cnpha.com
Country: China
ProdList: 28
Advantage: 68

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View Lastest Price from CUCURBITACIN B manufacturers

Henan Fengda Chemical Co., Ltd

Product: CUCURBITACIN B 6199-67-3
Price: US $8.00-0.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

Hebei Yanxi Chemical Co., Ltd.

Product: Cucurbitacin B 6199-67-3
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-27

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Cucurbitacin B 6199-67-3
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: Cucurbitacin B≥60%
Supply Ability: 500kg
Release date: 2021-12-13

6199-67-3, CUCURBITACIN BRelated Search:

CUCURBITACIN D,CUCURBITACIN D WITH HPLC CUCURBITACIN E(SH),CUCURBITACIN E,CUCURBITACIN E hplc,CUCURBITACIN E WITH HPLC 24-epi-Cucurbitacin G,Cucurbitacin G,Cucurbitacin H Cucurbitacin A Cucurbitacin F Cucurbitacin L dihydrocucurbitacin F Calebassine Cucurbitacin Ia,Cucurbitacin F-25-acetate CUCURBITACIN B 4-TERT-PENTYLCYCLOHEXANONE 4-tert-Butylcyclohexanone CUCURBITACIN D(SH) Cucurbitacin C Cucurbitacin IIb CUCURBITACIN IIA CUCURBITACIN I WITH HPLC,Cucurbitacin I hydrate,CUCURBITACIN I hplc,CUCURBITACIN I(SH),CUCURBITACIN I (E,Z)-2,13-OCTADECADIENOL

(2beta,9beta,10alpha,16alpha,23e)-thyl

19-nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione,2-beta,16-alpha,20,25

19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet

19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me

25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-tr

Cucurbitacin B hydrate

Cucurbitacin B, 98%, from Cucumis melo L.

cucurbitacineb

AMARINE

1,2-DIHYDRO-ALPHA-ELATERIN

CUCURBITACIN B

DATISCACIN

Dihydrocucurbitacin F-25-acetate

Cucurbitacin

HSDB 3476

CUCURBITACIN B(RG)

(23E)-25-(Acetyloxy)-2β,16α,20-trihydroxycucurbita-5,23-diene-3,11,22-trione

(9β,10α,23E)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione

NSC-144154

Cucurbitacin B ,97%

CUCURBITACIN B(P)

heMsecin A

Cucurbitacin B, froM CucuMis Melo

(2β,9β,10α,16α,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-Norlanosta-5,23-diene-3,11,22-trione

Cucurbitacin B, >99%

Cucurbitacin B, 98%, from Cucumis melo

BCucurbitacin B

Cuc B

19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2β,9β,10α,16α,23E)-

CUCURBITACIN B USP/EP/BP

CAS?6199-67-3?Combretastatin A4 (Z) -Combretastatin A4 CAS 117048-59-6

cucuritacin B

(+)-Cucurbitacin B

(R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate

6199-67-3

C32H46O8

Tri-Terpenoids

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract