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CUCURBITACIN B

Product Name
CUCURBITACIN B
CAS No.
6199-67-3
Chemical Name
CUCURBITACIN B
Synonyms
Cuc B;AMARINE;HSDB 3476;DATISCACIN;NSC-144154;heMsecin A;Cucurbitacin;cucuritacin B;cucurbitacineb;CUCURBITACIN B
CBNumber
CB5113260
Molecular Formula
C32H46O8
Formula Weight
558.7
MOL File
6199-67-3.mol
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CUCURBITACIN B Property

Melting point:
184-186°
alpha 
D25 +88° (c = 1.55 in ethanol)
Boiling point:
546.74°C (rough estimate)
Density 
1.0953 (rough estimate)
refractive index 
1.4900 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
pka
12.60±0.29(Predicted)
color 
white to beige
λmax
290nm(EtOH)(lit.)
Merck 
14,2614
Stability:
Hygroscopic
InChIKey
IXQKXEUSCPEQRD-ALLWXVAWSA-N
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45-24/25
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
3
RTECS 
RC6190000
HazardClass 
6.1
PackingGroup 
II
HS Code 
29153900
Hazardous Substances Data
6199-67-3(Hazardous Substances Data)
Toxicity
LD10 orally in mice: 5 mg/kg (LeMen)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C8499
Product name
Cucurbitacin B hydrate
Purity
≥97% (HPLC)
Packaging
5mg
Price
$256
Updated
2024/03/01
Sigma-Aldrich
Product number
C8499
Product name
Cucurbitacin B hydrate
Purity
≥97% (HPLC)
Packaging
25mg
Price
$1020
Updated
2024/03/01
TCI Chemical
Product number
C3442
Product name
Cucurbitacin B
Purity
>98.0%(HPLC)
Packaging
5mg
Price
$158
Updated
2024/03/01
TCI Chemical
Product number
C3442
Product name
Cucurbitacin B
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$478
Updated
2024/03/01
Cayman Chemical
Product number
14820
Product name
Cucurbitacin B
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
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CUCURBITACIN B Chemical Properties,Usage,Production

Description

Cucurbitacin B is a tetracyclic triterpenoid that has been shown to have a strong antitumor activity.

Chemical Properties

White solid

Uses

Cucurbitacin B hydrate has been used:

  • as a signal transducer and activator of transcription 3 (stat3) inhibitor to determine its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs).
  • as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydoxyecdysone (20E) signaling in butterflies.
  • to determine its effect on the cell viability of pancreatic cancer cell lines.

Definition

ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.

Biochem/physiol Actions

Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I.

CUCURBITACIN B Preparation Products And Raw materials

Raw materials

Preparation Products

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CUCURBITACIN B Suppliers

Hubei wei shi reagent group ltd., company
Tel
027-02759101766 13125137661
Email
2853877621@qq.com
Country
China
ProdList
5968
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
19179
Advantage
64
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Aktin Chemicals, Inc.
Tel
86-28-85159085
Fax
86-28-85152372
Email
info@aktinchem.com
Country
China
ProdList
297
Advantage
62
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View Lastest Price from CUCURBITACIN B manufacturers

Sinoway Industrial co., ltd.
Product
Cucurbitacin 6199-67-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
20tons
Release date
2024-12-03
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cucurbitacin B 6199-67-3
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
Cucurbitacin B≥60%
Supply Ability
500kg
Release date
2021-12-13
Baoji Guokang Bio-Technology Co., Ltd.
Product
CUCURBITACIN B 6199-67-3
Price
US $998.00/g
Min. Order
1g
Purity
98%
Supply Ability
1-20kg
Release date
2021-06-08

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