ChemicalBook > CAS DataBase List > CUCURBITACIN B

CUCURBITACIN B

Product Name
CUCURBITACIN B
CAS No.
6199-67-3
Chemical Name
CUCURBITACIN B
Synonyms
Cuc B;AMARINE;HSDB 3476;DATISCACIN;NSC-144154;heMsecin A;Cucurbitacin;cucuritacin B;cucurbitacineb;CUCURBITACIN B
CBNumber
CB5113260
Molecular Formula
C32H46O8
Formula Weight
558.7
MOL File
6199-67-3.mol
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CUCURBITACIN B Property

Melting point:
184-186°
alpha 
D25 +88° (c = 1.55 in ethanol)
Boiling point:
546.74°C (rough estimate)
Density 
1.0953 (rough estimate)
refractive index 
1.4900 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
pka
12.60±0.29(Predicted)
color 
white to beige
λmax
290nm(EtOH)(lit.)
Merck 
14,2614
Stability:
Hygroscopic
InChIKey
IXQKXEUSCPEQRD-ALLWXVAWSA-N
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45-24/25
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
3
RTECS 
RC6190000
HazardClass 
6.1
PackingGroup 
II
HS Code 
29153900
Hazardous Substances Data
6199-67-3(Hazardous Substances Data)
Toxicity
LD10 orally in mice: 5 mg/kg (LeMen)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C8499
Product name
Cucurbitacin B hydrate
Purity
≥97% (HPLC)
Packaging
5mg
Price
$256
Updated
2024/03/01
Sigma-Aldrich
Product number
C8499
Product name
Cucurbitacin B hydrate
Purity
≥97% (HPLC)
Packaging
25mg
Price
$1020
Updated
2024/03/01
TCI Chemical
Product number
C3442
Product name
Cucurbitacin B
Purity
>98.0%(HPLC)
Packaging
5mg
Price
$158
Updated
2024/03/01
TCI Chemical
Product number
C3442
Product name
Cucurbitacin B
Purity
>98.0%(HPLC)
Packaging
25mg
Price
$478
Updated
2024/03/01
Cayman Chemical
Product number
14820
Product name
Cucurbitacin B
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
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CUCURBITACIN B Chemical Properties,Usage,Production

Description

Cucurbitacin B is a tetracyclic triterpenoid that has been shown to have a strong antitumor activity.

Chemical Properties

White solid

Uses

Cucurbitacin B hydrate has been used:

  • as a signal transducer and activator of transcription 3 (stat3) inhibitor to determine its effect on the expression of human lysosomal acid lipase (hLAL) in myeloid-derived suppressor cells (MDSCs).
  • as an ecdysone receptor (EcR) antagonist injection to lower the levels of 20-hydoxyecdysone (20E) signaling in butterflies.
  • to determine its effect on the cell viability of pancreatic cancer cell lines.

Definition

ChEBI: A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 5 and 23; a hydroxy function at C-25 is acetylated.

Biochem/physiol Actions

Cucurbitacin B is a triterpenoid constituent of Cucurbitaceae plant species. Cucurbitacin B inhibits proliferation in a wide variety of tumor cell lines (IC50 15-30 nM) by inducing apoptosis and inducing cell cycle arrest at G2/M phase. Although the mechanism of action is unclear, Cucurbitacin B inhibits STAT 3 phosphorylation and expression levels and has been shown to block JAK2 activity. Curcubitacin B also inhibits the transcriptional activity of HIF1a and Nf-KB. Curcubitacin B is structurally similar to the JAK inhibitor Curcubitacin I.

CUCURBITACIN B Preparation Products And Raw materials

Raw materials

Preparation Products

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CUCURBITACIN B Suppliers

Americas 1 China 229 Europe 1 India 2 Japan 1 United Kingdom 3 United States 22 USA 1 Global 260
Hubei wei shi reagent group ltd., company
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View Lastest Price from CUCURBITACIN B manufacturers

Henan Fengda Chemical Co., Ltd
Product
CUCURBITACIN B 6199-67-3
Price
US $8.00-0.80/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Hebei Yanxi Chemical Co., Ltd.
Product
Cucurbitacin B 6199-67-3
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-27
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Cucurbitacin B 6199-67-3
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
Cucurbitacin B≥60%
Supply Ability
500kg
Release date
2021-12-13

6199-67-3, CUCURBITACIN BRelated Search:

CUCURBITACIN D,CUCURBITACIN D WITH HPLC CUCURBITACIN E(SH),CUCURBITACIN E,CUCURBITACIN E hplc,CUCURBITACIN E WITH HPLC 24-epi-Cucurbitacin G,Cucurbitacin G,Cucurbitacin H Cucurbitacin A Cucurbitacin F Cucurbitacin L dihydrocucurbitacin F Calebassine Cucurbitacin Ia,Cucurbitacin F-25-acetate CUCURBITACIN B 4-TERT-PENTYLCYCLOHEXANONE 4-tert-Butylcyclohexanone CUCURBITACIN D(SH) Cucurbitacin C Cucurbitacin IIb CUCURBITACIN IIA CUCURBITACIN I WITH HPLC,Cucurbitacin I hydrate,CUCURBITACIN I hplc,CUCURBITACIN I(SH),CUCURBITACIN I (E,Z)-2,13-OCTADECADIENOL

  • (2beta,9beta,10alpha,16alpha,23e)-thyl
  • 19-nor-9-beta,10-alpha-lanosta-5,23-diene-3,11,22-trione,2-beta,16-alpha,20,25
  • 19-nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione,2beta,16alpha,20,25-tet
  • 19-norlanosta-5,23-diene-3,11,22-trione,25-(acetyloxy)-2,16,20-trihydroxy-9-me
  • 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-tr
  • Cucurbitacin B hydrate
  • Cucurbitacin B, 98%, from Cucumis melo L.
  • cucurbitacineb
  • AMARINE
  • 1,2-DIHYDRO-ALPHA-ELATERIN
  • CUCURBITACIN B
  • DATISCACIN
  • Dihydrocucurbitacin F-25-acetate
  • Cucurbitacin
  • HSDB 3476
  • CUCURBITACIN B(RG)
  • (23E)-25-(Acetyloxy)-2β,16α,20-trihydroxycucurbita-5,23-diene-3,11,22-trione
  • (9β,10α,23E)-25-(Acetyloxy)-2β,16α,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione
  • NSC-144154
  • Cucurbitacin B ,97%
  • CUCURBITACIN B(P)
  • heMsecin A
  • Cucurbitacin B, froM CucuMis Melo
  • (2β,9β,10α,16α,23E)-25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-19-Norlanosta-5,23-diene-3,11,22-trione
  • Cucurbitacin B, >99%
  • Cucurbitacin B, 98%, from Cucumis melo
  • BCucurbitacin B
  • Cuc B
  • 19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2β,9β,10α,16α,23E)-
  • CUCURBITACIN B USP/EP/BP
  • CAS?6199-67-3?Combretastatin A4 (Z) -Combretastatin A4 CAS 117048-59-6
  • cucuritacin B
  • (+)-Cucurbitacin B
  • (R,E)-6-((2S,8S,9R,10R,13R,14S,16R,17R)-2,16-dihydroxy-4,4,9,13,14-pentamethyl-3,11-dioxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-6-hydroxy-2-methyl-5-oxohept-3-en-2-yl acetate
  • 6199-67-3
  • C32H46O8
  • Tri-Terpenoids
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract