3,4,5-Trifluorophenylboronic acid
Uses- Product Name
- 3,4,5-Trifluorophenylboronic acid
- CAS No.
- 143418-49-9
- Chemical Name
- 3,4,5-Trifluorophenylboronic acid
- Synonyms
- AKOS BRN-0138;3,4,5-Trifluoropheny;3,4,5-trifluoroborate;5-Trifluorophenylboronic acid;3,4,5-three fluorophenyl borate;3,4,5-Trifluophenylboronic acid;3,4,5-TRIFLUOROPHENYLBORONIC ACID;3,4,5-TRIFLUOROBENZENEBORONIC ACID;3,4,5-Trifluorophenylboronic Aicd;3,4,5-Trifluorobenzeneboronicacid97%
- CBNumber
- CB6481302
- Molecular Formula
- C6H4BF3O2
- Formula Weight
- 175.9
- MOL File
- 143418-49-9.mol
3,4,5-Trifluorophenylboronic acid Property
- Melting point:
- 290-295 °C (lit.)
- Boiling point:
- 263.6±50.0 °C(Predicted)
- Density
- 1,087g/cm
- refractive index
- 1,423-1,425
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- 18.43g/l
- form
- Powder
- pka
- 6.54±0.11(Predicted)
- color
- Tan
- BRN
- 7371914
- InChI
- InChI=1S/C6H4BF3O2/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,11-12H
- InChIKey
- UHDDEIOYXFXNNJ-UHFFFAOYSA-N
- SMILES
- B(C1=CC(F)=C(F)C(F)=C1)(O)O
- CAS DataBase Reference
- 143418-49-9(CAS DataBase Reference)
Safety
- Hazard Codes
- N-Xn,Xi
- Risk Statements
- 51/53-36-22-36/37/38
- Safety Statements
- 61-26-37/39-36
- RIDADR
- 3077
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 524700
- Product name
- 3,4,5-Trifluorophenylboronic acid
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $29.1
- Updated
- 2023/06/20
- Product number
- 524700
- Product name
- 3,4,5-Trifluorophenylboronic acid
- Purity
- ≥95%
- Packaging
- 5g
- Price
- $134
- Updated
- 2023/06/20
- Product number
- L18519
- Product name
- 3,4,5-Trifluorobenzeneboronic acid, 97%
- Packaging
- 250mg
- Price
- $56
- Updated
- 2023/06/20
- Product number
- L18519
- Product name
- 3,4,5-Trifluorobenzeneboronic acid, 97%
- Packaging
- 1g
- Price
- $181
- Updated
- 2023/06/20
- Product number
- CS-D1006
- Product name
- 3,4,5-Trifluorophenylboronic acid
- Purity
- 99.51%
- Packaging
- 500g
- Price
- $333
- Updated
- 2021/12/16
3,4,5-Trifluorophenylboronic acid Chemical Properties,Usage,Production
Uses
Reactant involved in:
• Preparation of phenylboronic catechol esters and determination of Lewis acidity
• Synthesis of benzopyranone derivatives as GABAA receptor modulators
• Synthesis of multisubstituted olefins and conjugate dienes
• Suzuki cross-coupling reactions
• Preparation of fluorinated aromatic poly(ether-amide)s
Description
3,4,5-Trifluorophenylboronic acid is an arylboronic acid compound used in organic synthesis and as a reaction reagent. It can be used as a catalyst to catalyse the direct amidation of amino acid derivatives and the direct polycondensation of carboxylic acids and amines; it can also be used in the formation of new 1:1 co-crystals with urea C6H4BF3O2-CH4N2O components.
Chemical Properties
Tan powder
Uses
suzuki reaction
Uses
Reactant involved in:
- Preparation of phenylboronic catechol esters and determination of Lewis acidity
- Synthesis of benzopyranone derivatives as GABAA receptor modulators
- Synthesis of multisubstituted olefins and conjugate dienes
- Suzuki cross-coupling reactions
- Preparation of fluorinated aromatic poly(ether-amide)s
Uses
Intermediates of Liquid Crystals
Synthesis
Add 42mmol (10.08g) of magnesium chips into a 1000mL four-necked flask, add 2 pieces of iodine, and then add 200mL of anhydrous 2-methyltetrahydrofuran, heat the temperature to 50°C, and then slowly let it cool down to 40°C. And then drip 4-5mL of 3,4,5-trifluorobromobenzene 84.4g (0.4mol) and 50mL 2-methyltetrahydrofuran mixed solution, trigger the Grignard reaction, the temperature will rise rapidly after the reaction is initiated, use The temperature is lowered to 10-15°C in an ice-water bath, and a mixture (1) composed of 3,4,5-trifluorobromobenzene 84.4g (0.4mol) and 50mL 2-methyltetrahydrofuran (1), trimethyl borate is added dropwise. A mixture of 44 grams (0.42 mol) of ester and 50 mL of 2-methyltetrahydrofuran (2).The speed of the mixed solution (1) and the mixed solution (2) is kept the same, the dropping speed is controlled, and the dropping temperature is kept at 10-15°C . After the dropping is completed, the reaction is continued at room temperature for 8 hours.After the reaction is over, the reaction solution is slowly poured into dilute hydrochloric acid, and after the addition is complete, stir for 0.5-1.5h, separate the liquids, and then extract the aqueous phase twice, combine the organic phases, dry with anhydrous sodium sulfate, spin dry, and Recrystallization of ethyl chloride gave 3,4,5-Trifluorophenylboronic acid with a yield of 78% and a content of 99.6%.
3,4,5-Trifluorophenylboronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,4,5-Trifluorophenylboronic acid manufacturers
- Product
- 3,4,5-Trifluorophenylboronic acid 143418-49-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10000KGS
- Release date
- 2024-11-18
- Product
- 3,4,5-Trifluorophenylboronic acid 143418-49-9
- Price
- US $10.00-1000.00/g
- Min. Order
- 5mg
- Purity
- 99.0% HPLC
- Supply Ability
- 2000tons
- Release date
- 2021-03-09
- Product
- 3,4,5-Trifluorophenylboronic acid 143418-49-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-31