Uses
ChemicalBook > CAS DataBase List > 3,4,5-Trifluorophenylboronic acid

3,4,5-Trifluorophenylboronic acid

Uses
Product Name
3,4,5-Trifluorophenylboronic acid
CAS No.
143418-49-9
Chemical Name
3,4,5-Trifluorophenylboronic acid
Synonyms
AKOS BRN-0138;CAS:143418-49-9;3,4,5-Trifluoropheny;3,4,5-trifluoroborate;5-Trifluorophenylboronic acid;3,4,5-three fluorophenyl borate;3,4,5-Trifluophenylboronic acid;3,4,5-TRIFLUOROPHENYLBORONIC ACID;3,4,5-TRIFLUOROBENZENEBORONIC ACID;3,4,5-Trifluorophenylboronic Aicd
CBNumber
CB6481302
Molecular Formula
C6H4BF3O2
Formula Weight
175.9
MOL File
143418-49-9.mol
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3,4,5-Trifluorophenylboronic acid Property

Melting point:
290-295 °C (lit.)
Boiling point:
263.6±50.0 °C(Predicted)
Density 
1,087g/cm
refractive index 
1,423-1,425
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
18.43g/l
form 
Powder
pka
6.54±0.11(Predicted)
color 
Tan
BRN 
7371914
InChI
InChI=1S/C6H4BF3O2/c8-4-1-3(7(11)12)2-5(9)6(4)10/h1-2,11-12H
InChIKey
UHDDEIOYXFXNNJ-UHFFFAOYSA-N
SMILES
B(C1=CC(F)=C(F)C(F)=C1)(O)O
CAS DataBase Reference
143418-49-9(CAS DataBase Reference)
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Safety

Hazard Codes 
N-Xn,Xi
Risk Statements 
51/53-36-22-36/37/38
Safety Statements 
61-26-37/39-36
RIDADR 
3077
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
524700
Product name
3,4,5-Trifluorophenylboronic acid
Purity
≥95%
Packaging
1g
Price
$29.1
Updated
2023/06/20
Sigma-Aldrich
Product number
524700
Product name
3,4,5-Trifluorophenylboronic acid
Purity
≥95%
Packaging
5g
Price
$134
Updated
2023/06/20
Alfa Aesar
Product number
L18519
Product name
3,4,5-Trifluorobenzeneboronic acid, 97%
Packaging
250mg
Price
$56
Updated
2023/06/20
Alfa Aesar
Product number
L18519
Product name
3,4,5-Trifluorobenzeneboronic acid, 97%
Packaging
1g
Price
$181
Updated
2023/06/20
ChemScene
Product number
CS-D1006
Product name
3,4,5-Trifluorophenylboronic acid
Purity
99.51%
Packaging
500g
Price
$333
Updated
2021/12/16
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3,4,5-Trifluorophenylboronic acid Chemical Properties,Usage,Production

Uses

Reactant involved in:
• Preparation of phenylboronic catechol esters and determination of Lewis acidity
• Synthesis of benzopyranone derivatives as GABAA receptor modulators
• Synthesis of multisubstituted olefins and conjugate dienes
• Suzuki cross-coupling reactions
• Preparation of fluorinated aromatic poly(ether-amide)s

Description

3,4,5-Trifluorophenylboronic acid is an arylboronic acid compound used in organic synthesis and as a reaction reagent. It can be used as a catalyst to catalyse the direct amidation of amino acid derivatives and the direct polycondensation of carboxylic acids and amines; it can also be used in the formation of new 1:1 co-crystals with urea C6H4BF3O2-CH4N2O components.

Chemical Properties

Tan powder

Uses

suzuki reaction

Uses

Reactant involved in:

  • Preparation of phenylboronic catechol esters and determination of Lewis acidity
  • Synthesis of benzopyranone derivatives as GABAA receptor modulators
  • Synthesis of multisubstituted olefins and conjugate dienes
  • Suzuki cross-coupling reactions
  • Preparation of fluorinated aromatic poly(ether-amide)s

Uses

Intermediates of Liquid Crystals

Synthesis

Add 42mmol (10.08g) of magnesium chips into a 1000mL four-necked flask, add 2 pieces of iodine, and then add 200mL of anhydrous 2-methyltetrahydrofuran, heat the temperature to 50°C, and then slowly let it cool down to 40°C. And then drip 4-5mL of 3,4,5-trifluorobromobenzene 84.4g (0.4mol) and 50mL 2-methyltetrahydrofuran mixed solution, trigger the Grignard reaction, the temperature will rise rapidly after the reaction is initiated, use The temperature is lowered to 10-15°C in an ice-water bath, and a mixture (1) composed of 3,4,5-trifluorobromobenzene 84.4g (0.4mol) and 50mL 2-methyltetrahydrofuran (1), trimethyl borate is added dropwise. A mixture of 44 grams (0.42 mol) of ester and 50 mL of 2-methyltetrahydrofuran (2).The speed of the mixed solution (1) and the mixed solution (2) is kept the same, the dropping speed is controlled, and the dropping temperature is kept at 10-15°C . After the dropping is completed, the reaction is continued at room temperature for 8 hours.After the reaction is over, the reaction solution is slowly poured into dilute hydrochloric acid, and after the addition is complete, stir for 0.5-1.5h, separate the liquids, and then extract the aqueous phase twice, combine the organic phases, dry with anhydrous sodium sulfate, spin dry, and Recrystallization of ethyl chloride gave 3,4,5-Trifluorophenylboronic acid with a yield of 78% and a content of 99.6%.

3,4,5-Trifluorophenylboronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4,5-Trifluorophenylboronic acid Suppliers

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View Lastest Price from 3,4,5-Trifluorophenylboronic acid manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3,4,5-Trifluorophenylboronic acid 143418-49-9
Price
US $10.00-1000.00/g
Min. Order
5mg
Purity
99.0% HPLC
Supply Ability
2000tons
Release date
2021-03-09
Shaanxi Dideu New Materials Co. Ltd
Product
3,4,5-Trifluorophenylboronic acid 143418-49-9
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10000KGS
Release date
2024-11-18
Hebei Weibang Biotechnology Co., Ltd
Product
3,4,5-Trifluorophenylboronic acid 143418-49-9
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-31

143418-49-9, 3,4,5-Trifluorophenylboronic acidRelated Search:

Trimethyl borate 2,3,4,5,6-PENTAFLUOROBENZENEBORONIC ACID Triisopropyl borate Phenylboronic acid 4-Fluorobenzeneboronic acid Tributyl borate 3,5-Difluorophenylboronic acid 2,3,4,5-TETRAFLUOROBENZENEBORONIC ACID 2,3,6-Trifluorophenylboronic acid 2,3,4-Trifluorophenylboronic Acid (contains varying amounts of Anhydride),4-TRIFLUOROPHENYLBORONIC ACID,2,3,4-TRIFLUOROPHENYLBORONIC ACID 2,3,6-TRIFLUOROPHENYLBORONIC ACID 2,4,6-TRIFLUOROPHENYLBORONIC ACID 5-Bromo-2,3,4-Trifluorophenylboronic acid 2,4,5-TRIFLUOROPHENYLBORONIC ACID 6-Bromo-2,3,4-Trifluorophenylboronic acid 2,4,5-TRIFLUOROPHENYLBORONIC ACID,2,3,5-TRIFLUOROPHENYLBORONIC ACID 2,4,5-Trifluorophenylboronic acid Boric acid

  • AKOS BRN-0138
  • 3,4,5-TRIFLUOROPHENYLBORONIC ACID
  • 3,4,5-TRIFLUOROBENZENEBORONIC ACID
  • 3,4,5-Trifluophenylboronic acid
  • 3,4,5-Trifluorobenzeneboronic acid 97%
  • 3,4,5-Trifluorobenzeneboronicacid97%
  • 3,4,5-TRIFLUOROPHENYLBORONIC ACID MIN 96% HPLC
  • 3,4,5-Trifluorophenylboronic Aicd
  • Boronic acid, B-(3,4,5-trifluorophenyl)-
  • 3,4,5-Trifluorophenylboronic acid ,97%
  • 3,4,5-TRIFLUOROPHENYLBORONIC ACID, 95+%
  • 3,4,5-Trifluoropheny
  • 3,4,5-three fluorophenyl borate
  • 5-Trifluorophenylboronic acid
  • 3,4,5-Trifluorophenylboronic acid (contains varying aMounts of Anhydride)
  • dihydroxy(3,4,5-trifluorophenyl)borane
  • 3,4,5-TRIFLUOROPHENYLBORONIC ACID FOR SY
  • 3,4,5-TRIFLUOROPHENYL BORONIC ACID;BORONIC ACID, B-(3,4,5-TRIFLUOROPHENYL)-;
  • 3,4,5-trifluoroborate
  • CAS:143418-49-9
  • 143418-49-9
  • 143418-49-8
  • 443418-49-9
  • 418-49-9
  • Boronic Acids and Derivatives
  • Boronic Acids
  • Aryl
  • Organometallic Reagents
  • BORONIC ACID
  • Piperidines
  • Boronic Acids
  • Boronic Acids
  • Boronic Acids and Derivatives
  • Aryl
  • Fluorinated
  • Organoborons
  • Substituted Boronic Acids
  • Fluorin-contained phenyl boronic acid series
  • Boronic Acid
  • blocks
  • BoronicAcids
  • Boronic Acid series
  • Fluoro-Aromatics