5-vinyl-uridine

Product Name: 5-vinyl-uridine
CAS No.: 55520-64-4
Chemical Name: 5-vinyl-uridine
Synonyms: 5-vinyl-uridine;5-Ethenyluridine;Uridine, 5-ethenyl-;5-Vinyl-uridine (5-VU);1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-vinylpyrimidine-2,4(1H,3H)-dione
CBNumber: CB64849397
Molecular Formula: C11H14N2O6
Formula Weight: 270.24
MOL File: 55520-64-4.mol

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5-vinyl-uridine Property

Melting point:: 250-255 °C (decomp)
Density: 1.641±0.06 g/cm3(Predicted)
solubility: DMSO, methanol
pka: 9.07±0.10(Predicted)
Appearance: white solid

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Hazard and Precautionary Statements (GHS)

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5-vinyl-uridine Chemical Properties,Usage,Production

Description

5-Vinyl-uridine (VU) is a uridine derivative with a terminal alkene group that can be used for monitoring and investigating RNA transcription in cells instead of 5-ethynyl-uridine (EU).

VU is readily taken up by living cells and incorporated by RNA polymerases into de novo RNA instead of endogenous uridine, but not into DNA [1]. VU-labeled nascent cellular RNA can be detected quickly and with high sensitivity via inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA) between the vinyl group and fluorescently or biotin-labeled tetrazines.

Labeled RNA can be detected with different cell transcriptional levels estimation methods, e.g., fluorescent microscopy or flow cytometry.

[1] Liu H.S. et al. A Nucleoside Derivative 5-Vinyluridine (VrU) for Imaging RNA in Cells and Animals. Bioconjug.Chem. 2019. 30(11). 2958-2966.

5-vinyl-uridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-vinyl-uridine Suppliers

China 10 United States 2 Global 12

Shanghai EFE Biological Technology Co., Ltd.

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View Lastest Price from 5-vinyl-uridine manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: 5-vinyl-uridine 55520-64-4
Price: US $0.00/mg
Min. Order: 500mg
Purity: >95.00%
Supply Ability: 500mg
Release date: 2024-03-30

55520-64-4, 5-vinyl-uridineRelated Search:

5-vinyl-2'-deoxyuridine 5-Ethynyl uridine 5-ETHYNYL-2'-DEOXYURIDINE

5-vinyl-uridine

Uridine, 5-ethenyl-

5-Vinyl-uridine (5-VU)

5-Ethenyluridine

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-vinylpyrimidine-2,4(1H,3H)-dione

55520-64-4