ChemicalBook > CAS DataBase List > 5-ETHYNYL-2'-DEOXYURIDINE

5-ETHYNYL-2'-DEOXYURIDINE

Product Name
5-ETHYNYL-2'-DEOXYURIDINE
CAS No.
61135-33-9
Chemical Name
5-ETHYNYL-2'-DEOXYURIDINE
Synonyms
abs9124;EYdU;5-E-dU;Uridine,2;Aids072372;Aids-072372;5-Ethynyl-dU;-deoxyuridine;5-Ethynyl-durd;5-Ethynyl-2'-dU
CBNumber
CB0243359
Molecular Formula
C11H12N2O5
Formula Weight
252.22
MOL File
61135-33-9.mol
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5-ETHYNYL-2'-DEOXYURIDINE Property

Melting point:
199°C(lit.)
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 10 mg/ml).
pka
8.29±0.10(Predicted)
form 
powder
color 
White or off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey
CDEURGJCGCHYFH-DJLDLDEBSA-N
CAS DataBase Reference
61135-33-9
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Safety

Hazard Codes 
T
Risk Statements 
46-61
Safety Statements 
53-45-24/25
RTECS 
YU7510000
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H340May cause genetic defects

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
900584
Product name
5-Ethynyl-2′-deoxyuridine
Purity
95%
Packaging
50mg
Price
$147
Updated
2024/03/01
Sigma-Aldrich
Product number
900584
Product name
5-Ethynyl-2′-deoxyuridine
Purity
95%
Packaging
500mg
Price
$1030
Updated
2024/03/01
TCI Chemical
Product number
E1057
Product name
5-Ethynyl-2'-deoxyuridine
Purity
>98.0%(HPLC)(T)
Packaging
50mg
Price
$89
Updated
2024/03/01
TCI Chemical
Product number
E1057
Product name
5-Ethynyl-2'-deoxyuridine
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$258
Updated
2024/03/01
Cayman Chemical
Product number
20518
Product name
5-Ethynyl-2'-deoxyuridine
Purity
≥98%
Packaging
50mg
Price
$44
Updated
2024/03/01
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5-ETHYNYL-2'-DEOXYURIDINE Chemical Properties,Usage,Production

Description

5-Ethynyl-2′-deoxyuridine (61135-33-9) is a novel agent for fast and sensitive detection of DNA synthesis?in vivo.1 5-EdU is incorporated into proliferating cells followed by detection with a fluorescent azide using click ligation.1 In contrast to the use of BrdU, the new method does not require sample fixation or DNA denaturation. 5-Ethynyl-2′-deoxyuridine may be used for studying cell proliferation in the central nervous system and may be combined with BrdU staining in a novel protocol allowing for double labeling of DNA synthesis.2

Uses

5-Ethynyl-2’deoxyuridine is a extensively used nucleoside analog used as a probe for DNA synthesis. However, 5-Ethynyl-2’deoxyuridine is a toxic anti-metabolite, which potentially causes DNA instabi liy, necrosis and cell-cycle arrest, therefore it is often used for short-term DNA synthesis in tissue culture and living organisms where prolonged cell survival is not required.

Uses

5-Ethynyl-2′-deoxyuridine (EdU) is a thymidine analog that can be incorporated into replicating DNA for detection of cell proliferation. It has an alkyne handle that can ligate with azide-containing fluorescent probes through a highly efficient click chemistry reaction. EdU nucleoside can be incorporated into the DNA of cells either in culture or in animals without showing significant toxicity. The assay offers a simpler workflow for detecting cell proliferation than anti-BrdU assays.

For information on Baseclick kits containing all the reagents for the assays see: Baseclick kits

For a listing of the Baseclick kits see: Baseclick kits

storage

Store at -20°C

References

1) Salic and Mitchison (2008),?A chemical method for fast and sensitive detection of DNA synthesis in vivo; Proc. Natl. Acad. Sci. USA,?105?2415 2) Zeng?et al. (2010),?Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system; Brain Res.,?1319C?21

5-ETHYNYL-2'-DEOXYURIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-ETHYNYL-2'-DEOXYURIDINE Suppliers

Wuhu Nuowei Chemical Technology Co., Ltd
Tel
0553-8233716 18055326116
Email
sales@nuowei-chem.com
Country
China
ProdList
951
Advantage
55
Maanshan geneyan biotech Co.,LTD
Tel
18913822354
Email
market@geneyan-bio.com
Country
China
ProdList
299
Advantage
58
Fuyang Ziyi Biological Pharmaceutical Co., Ltd.
Tel
19308655899
Fax
-
Email
2677609105@qq.com
Country
China
ProdList
464
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
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Hongene Biotech Corporation
Tel
021-64757213
Fax
86-21-64700613
Email
info@hongene.com
Country
China
ProdList
672
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
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81
Wuhu Huaren Science and Technology Co., Ltd.
Tel
0553-0553-0553-5842013-801-801 18155347026
Fax
086-553-5843138
Email
jinhuaren@huarensh.com
Country
China
ProdList
295
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
T&W GROUP
Tel
021-61551611 13296011611
Fax
+86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
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View Lastest Price from 5-ETHYNYL-2'-DEOXYURIDINE manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-Ethynyl-2'-deoxyuridine 61135-33-9
Price
US $0.00-0.00/g
Min. Order
10g
Purity
98%min
Supply Ability
1000g
Release date
2021-09-03
Xian confluore Biological Technology Co., Ltd.
Product
5-Ethynyl-2'-deoxyuridine 61135-33-9
Price
US $0.00/g
Min. Order
5g
Purity
>95.00%
Supply Ability
5g
Release date
2024-03-30
Henan Aochuang Chemical Co.,Ltd.
Product
5-ETHYNYL-2'-DEOXYURIDINE 61135-33-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27

61135-33-9, 5-ETHYNYL-2'-DEOXYURIDINERelated Search:


  • 5-ETHYNYL-2'-DEOXYURIDINE
  • 2’-deoxy-5-ethynyl-uridin
  • 2’-deoxy-5-ethynyluridine
  • EYdU
  • 5-Ethynyl-durd
  • Aids072372
  • Aids-072372
  • 2'deoxyuridine, 5-ethynyl
  • Uridine,2
  • 5-Ethynyl-2'-dU
  • EDU [5-Ethynyl-2'-deoxyuridine] *50 Mg*
  • Uridine,2'-deoxy-5-ethynyl-
  • 5-Ethynyl-2'-deoxyuridine, (EdU) AldrichCPR
  • 5-Ethynyl-2′-deoxyuridine, (EdU)
  • 5-Ethynyl-2'-deoxyuridine 95%
  • 5-Ethynyl-2'-deoxy-uridine (5-EdU)
  • 5-E-dU
  • EdU(5-ethynyl-2'-deoxyuridine)
  • 5-Ethynyl-dU
  • 5-Ethynyl-2'-deoxyuridine &gt
  • abs9124
  • -deoxyuridine
  • EdU(5-Ethynyl-2'-deoxyuridine)
  • 5-Ethynyl-2'-deoxyuridine(EdU)
  • 5-Ethynyl-2'-dU
  • 5-ETHYNYL-2'-DEOXYURIDINE
  • 61135-33-9
  • C11H12N2O5
  • SiChem