ChemicalBook > CAS DataBase List > 5-ETHYNYL-2'-DEOXYURIDINE

5-ETHYNYL-2'-DEOXYURIDINE

Product Name
5-ETHYNYL-2'-DEOXYURIDINE
CAS No.
61135-33-9
Chemical Name
5-ETHYNYL-2'-DEOXYURIDINE
Synonyms
abs9124;EYdU;5-E-dU;Uridine,2;Aids072372;Aids-072372;5-Ethynyl-dU;-deoxyuridine;5-Ethynyl-durd;5-Ethynyl-2'-dU
CBNumber
CB0243359
Molecular Formula
C11H12N2O5
Formula Weight
252.22
MOL File
61135-33-9.mol
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5-ETHYNYL-2'-DEOXYURIDINE Property

Melting point:
199°C(lit.)
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 10 mg/ml).
pka
8.29±0.10(Predicted)
form 
powder
color 
White or off-white
Appearance
light beige to light brown solid
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChI
InChI=1S/C11H12N2O5/c1-2-6-4-13(11(17)12-10(6)16)9-3-7(15)8(5-14)18-9/h1,4,7-9,14-15H,3,5H2,(H,12,16,17)/t7-,8+,9+/m0/s1
InChIKey
CDEURGJCGCHYFH-DJLDLDEBSA-N
SMILES
OC[C@H]1O[C@@H](N2C=C(C#C)C(=O)NC2=O)C[C@@H]1O
CAS DataBase Reference
61135-33-9
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Safety

Hazard Codes 
T
Risk Statements 
46-61
Safety Statements 
53-45-24/25
RTECS 
YU7510000
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H340May cause genetic defects

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
900584
Product name
5-Ethynyl-2′-deoxyuridine
Purity
95%
Packaging
50mg
Price
$152
Updated
2025/07/31
Sigma-Aldrich
Product number
900584
Product name
5-Ethynyl-2′-deoxyuridine
Purity
95%
Packaging
500mg
Price
$1007
Updated
2025/07/31
TCI Chemical
Product number
E1057
Product name
5-Ethynyl-2'-deoxyuridine
Purity
>98.0%(HPLC)(T)
Packaging
50mg
Price
$85
Updated
2025/07/31
TCI Chemical
Product number
E1057
Product name
5-Ethynyl-2'-deoxyuridine
Purity
>98.0%(HPLC)(T)
Packaging
200mg
Price
$245
Updated
2025/07/31
Cayman Chemical
Product number
20518
Product name
5-Ethynyl-2'-deoxyuridine
Purity
≥98%
Packaging
50mg
Price
$44
Updated
2024/03/01
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5-ETHYNYL-2'-DEOXYURIDINE Chemical Properties,Usage,Production

Description

5-Ethynyl-2′-deoxyuridine (61135-33-9) is a novel agent for fast and sensitive detection of DNA synthesis?in vivo.1 5-EdU is incorporated into proliferating cells followed by detection with a fluorescent azide using click ligation.1 In contrast to the use of BrdU, the new method does not require sample fixation or DNA denaturation. 5-Ethynyl-2′-deoxyuridine may be used for studying cell proliferation in the central nervous system and may be combined with BrdU staining in a novel protocol allowing for double labeling of DNA synthesis.2

Uses

5-Ethynyl-2’deoxyuridine is a extensively used nucleoside analog used as a probe for DNA synthesis. However, 5-Ethynyl-2’deoxyuridine is a toxic anti-metabolite, which potentially causes DNA instabi liy, necrosis and cell-cycle arrest, therefore it is often used for short-term DNA synthesis in tissue culture and living organisms where prolonged cell survival is not required.

Uses

5-Ethynyl-2′-deoxyuridine (EdU) is a thymidine analog that can be incorporated into replicating DNA for detection of cell proliferation. It has an alkyne handle that can ligate with azide-containing fluorescent probes through a highly efficient click chemistry reaction. EdU nucleoside can be incorporated into the DNA of cells either in culture or in animals without showing significant toxicity. The assay offers a simpler workflow for detecting cell proliferation than anti-BrdU assays.

For information on Baseclick kits containing all the reagents for the assays see: Baseclick kits

For a listing of the Baseclick kits see: Baseclick kits

storage

Store at -20°C

References

[1] ADRIAN SALIC  Timothy J M. A chemical method for fast and sensitive detection of DNA synthesis in vivo.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008, 105 7: 2415-2420. DOI:10.1073/pnas.0712168105
[2] CHENBO ZENG . Evaluation of 5-ethynyl-2′-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system[J]. Brain Research, 2010, 1319: Pages 21-32. DOI:10.1016/j.brainres.2009.12.092

5-ETHYNYL-2'-DEOXYURIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-ETHYNYL-2'-DEOXYURIDINE Suppliers

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View Lastest Price from 5-ETHYNYL-2'-DEOXYURIDINE manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
5-ETHYNYL-2'-DEOXYURIDINE 61135-33-9
Price
US $0.00-0.00/G
Min. Order
1G
Purity
98%
Supply Ability
2000
Release date
2025-06-04
WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-Ethynyl-2'-deoxyuridine 61135-33-9
Price
US $0.00-0.00/g
Min. Order
10g
Purity
98%min
Supply Ability
1000g
Release date
2021-09-03
Henan Aochuang Chemical Co.,Ltd.
Product
5-ETHYNYL-2'-DEOXYURIDINE 61135-33-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27

61135-33-9, 5-ETHYNYL-2'-DEOXYURIDINERelated Search:

5-Ethynyl uridine Netivudine 5-ETHYNYL-2'-DEOXYURIDINE FLUORESCEIN-12-DUTP FLUORESCEIN-12-UTP CHROMATIDE(TM) TEXAS RED(R)-5-DUTP DIETHYLAMINOCOUMARIN-5-DUTP FLUORESCEIN CHLOROTRIAZINYL-4-UTP LISSAMINE-5-UTP CHROMATIDE(TM) BODIPY(R) 630/650-14-DUTP 5-PROPYNYL-2'-DEOXYURIDINE-5'-TRIPHOSPHATE LITHIUM SALT NAPHTHOFLUORESCEIN-5-DUTP CHROMATIDE(TM) BODIPY(R) 650/665-14-DUTP CHROMATIDE(TM) TEXAS RED(R)-5-UTP COUMARIN-5-DUTP LISSAMINE-5-DUTP COUMARIN-5-UTP TETRAMETHYLRHODAMINE-6-DDUTP

  • 5-ETHYNYL-2'-DEOXYURIDINE
  • 2’-deoxy-5-ethynyl-uridin
  • 2’-deoxy-5-ethynyluridine
  • EYdU
  • 5-Ethynyl-durd
  • Aids072372
  • Aids-072372
  • 2'deoxyuridine, 5-ethynyl
  • Uridine,2
  • 5-Ethynyl-2'-dU
  • EDU [5-Ethynyl-2'-deoxyuridine] *50 Mg*
  • Uridine,2'-deoxy-5-ethynyl-
  • 5-Ethynyl-2'-deoxyuridine, (EdU) AldrichCPR
  • 5-Ethynyl-2′-deoxyuridine, (EdU)
  • 5-Ethynyl-2'-deoxyuridine 95%
  • 5-Ethynyl-2'-deoxy-uridine (5-EdU)
  • 5-E-dU
  • EdU(5-ethynyl-2'-deoxyuridine)
  • 5-Ethynyl-dU
  • 5-Ethynyl-2'-deoxyuridine &gt
  • abs9124
  • -deoxyuridine
  • 5-Ethynyl-2'-deoxyuridine(EdU)
  • EdU, DNA synthesis monitoring probe
  • 5-Ethynyl-2''-deoxyuridine
  • 5-Ethynyl-2''-deoxyuridine, 10 mM in DMSO
  • EdU (5-Ethynyl-2′-deoxyuridine) (CCT-1149)
  • 5-Ethynyl-2&#8242,-deoxyuridine (5-EdU) (100 mg)
  • 5-Ethynyl-2&#8242,-deoxyuridine (5-EdU) (25 mg)
  • 5-Ethynyl-2&#8242,-deoxyuridine (5-EdU) (5 g)
  • 5-Ethynyl-2&#8242,-deoxyuridine (5-EdU) (500 mg)
  • 61135-33-9
  • C11H12N2O5
  • SiChem