5-vinyl-uridine
- Product Name
- 5-vinyl-uridine
- CAS No.
- 55520-64-4
- Chemical Name
- 5-vinyl-uridine
- Synonyms
- 5-vinyl-uridine;5-Ethenyluridine;Uridine, 5-ethenyl-;5-Vinyl-uridine (5-VU);1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-vinylpyrimidine-2,4(1H,3H)-dione
- CBNumber
- CB64849397
- Molecular Formula
- C11H14N2O6
- Formula Weight
- 270.24
- MOL File
- 55520-64-4.mol
5-vinyl-uridine Property
- Melting point:
- 250-255 °C (decomp)
- Density
- 1.641±0.06 g/cm3(Predicted)
- solubility
- DMSO, methanol
- pka
- 9.07±0.10(Predicted)
- Appearance
- white solid
5-vinyl-uridine Chemical Properties,Usage,Production
Description
5-Vinyl-uridine (VU) is a uridine derivative with a terminal alkene group that can be used for monitoring and investigating RNA transcription in cells instead of 5-ethynyl-uridine (EU).
VU is readily taken up by living cells and incorporated by RNA polymerases into de novo RNA instead of endogenous uridine, but not into DNA [1]. VU-labeled nascent cellular RNA can be detected quickly and with high sensitivity via inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA) between the vinyl group and fluorescently or biotin-labeled tetrazines.
Labeled RNA can be detected with different cell transcriptional levels estimation methods, e.g., fluorescent microscopy or flow cytometry.
[1] Liu H.S. et al. A Nucleoside Derivative 5-Vinyluridine (VrU) for Imaging RNA in Cells and Animals. Bioconjug.Chem. 2019. 30(11). 2958-2966.
5-vinyl-uridine Preparation Products And Raw materials
Raw materials
Preparation Products
5-vinyl-uridine Suppliers
- Tel
- 16314854226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 9713
- Advantage
- 58
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19552
- Advantage
- 58
View Lastest Price from 5-vinyl-uridine manufacturers
- Product
- 5-vinyl-uridine 55520-64-4
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >95.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-30